ABSTRACT
Objetivo: El objetivo de este estudio es evaluar los efectos de la vacunación contra el SARS-CoV-2 sobre el patrón convulsivo en pacientes pediátricos con epilepsia que acudieron a nuestro centro terciario en la ciudad de Bogotá, Colombia. Pacientes y métodos: Se pidió a los niños con epilepsia que fueron tratados en nuestro centro y que habían recibido la vacuna contra el SARS-CoV-2 y a sus cuidadores que informaran de su experiencia después de la vacunación. Se documentaron la edad, el sexo, la edad de inicio de la epilepsia, la duración de la epilepsia, el tipo de epilepsia, la frecuencia de las convulsiones, el número de medicamentos, el tiempo transcurrido desde la última crisis, los esquemas de vacunación y las convulsiones dos semanas después de la vacunación. Resultados: Se incluyó a 101 pacientes con epilepsia (58%, hombres; y 42%, mujeres). La edad promedio fue de 11 años, el 73% tenía epilepsia focal, y el 27%, generalizada. Veintiuno cumplían los criterios para la epilepsia refractaria y 11 tenían antecedentes personales de convulsiones febriles. Cuarenta y siete pacientes habían sido vacunados con la vacuna de Sinovac; 41, con Pfizer; 12, con Moderna; y uno, con CoronaVac. Tres pacientes presentaron convulsiones 24 horas después de la aplicación de la vacuna sin una relación clara entre la vacunación y la frecuencia de las convulsiones, y un paciente requirió ingreso en el hospital por una convulsión prolongada. Conclusión: La vacunación contra el SARS-CoV-2 en pacientes pediátricos con epilepsia es segura. Aproximadamente el 3% de los pacientes con epilepsia podría eventualmente tener convulsiones en el período posterior a la vacunación.
Aim: The objective of this study is to evaluate effects of SARS-CoV-2 vaccination on seizure pattern in paediatric patients with epilepsy that attended our tertiary center in the city of Bogotá, Colombia. Patients and methods: Children with epilepsy who were treated at our center and have had SARS-CoV-2 vaccination and their caregivers were asked to report their experience following vaccination. We documented age, sex, age at onset of epilepsy, duration of epilepsy, epilepsy type, seizure frequency, number of medications, time from last crisis, vaccination schemes, and seizures two weeks after vaccination. Results: One hundred and one patients with epilepsy were included (58%, male; and 42%, female). The average age was 11 years, 73% had focal epilepsy, and 27%, generalized. Twenty-one fulfilled criteria for refractory epilepsy and 11 had a personal history of febrile seizures. Forty-seven patients had been vaccinated with Sinovacs vaccine; 41 patients, with Pfizers; 12 patients, with Modernas; and one, with CoronaVacs. Three patients presented seizures 24 hours after the application of the vaccine with no clear relation between vaccination and seizure frequency, and one patient required admission to the hospital for a prolonged seizure. Conclusion: Vaccination against SARS-CoV-2 in paediatric patients with epilepsy is safe. Approximately 3% of patients with epilepsy could eventually have seizures in the post-vaccination period.(AU)
Subject(s)
Humans , Male , Female , Child , Severe acute respiratory syndrome-related coronavirus , Coronavirus Infections/epidemiology , Coronavirus Infections/immunology , Pandemics , Epilepsy , Vaccination/adverse effects , Neurology , Nervous System Diseases , Pediatrics , Colombia , Seizures, FebrileABSTRACT
El objetivo de este estudio fue determinar la fiabilidad y la estructura factorial de la versión chilena del WHOQOL-BREF, el cuestionario de la Organización Mundial de la Salud para evaluar la calidad de vida. Una muestra no probabilística de 1205 adultos jóvenes (Medad= 18,6 años; DT= 1,8; 57,8% mujeres) contestaron el WHOQOL-BREF. Usando la matriz de correlaciones policóricas, diferentes modelos fueron estimados y comparados utilizando análisis factorial confirmatorio. Se compararon las puntuaciones según el sexo y el nivel socioeconómico confirmando las hipótesis relativas a la validez de constructo. El modelo bifactor, comparado con un modelo de factores correlacionados y uno de segundo orden, presentó el mejor ajuste a los datos (χ2 [222]= 961,694; p< 0,001; CFI= 0,966; TLI= 0,958; RMSEA= 0,053 [0,049-0,056]). La consistencia interna fue excelente (ω= 0,94). La versión chilena del WHOQOL-BREF tiene propiedades psicométricas robustas, permitiendo la medición de este constructo de forma válida y fiable en adultos jóvenes chilenos (AU)
The objective of this study was to determine the reliability and the factorial structure of the Chilean version scale of quality of life WHOQOL-BREF (World Health Organization). A non-probabilistic sample of 1205 adults (Mage= 18.6, SD= 1.8; 57.8% female) was surveyed during 2018. Using a polychoric correlation matrix, we tested and compared several models with a confirmatory factor analysis. Total scores were compared by sex and socioeconomic status, confirming the hypothesis about the construct validity. A bifactorial model, compared with a correlated factor model and a second-order model, showed better fit indexes (χ2[222]= 961.694, p< .001, CFI= .966, TLI= .958, RMSEA= .053 [.049-.056]). The internal reliability was excellent (ω= .94). The Chilean version of the WHOQOL-BREF is psychometrically sound, allowing to measure this construct reliably and validly in Chilean young adults (AU)
Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Adult , Surveys and Questionnaires , Quality of Life , Reproducibility of Results , Factor Analysis, Statistical , Socioeconomic Factors , Sex Factors , Psychometrics , ChileABSTRACT
Resumen La Neurofibromatosis (NF) es una genodermatosis autosómica dominante. La literatura reconoce varios síndromes clínicos diferentes dentro de los cuáles se describen tres formas principales: Neurofibromatosis tipo 1, Neurofibromatosis tipo 2 y Schwanomatosis. La más común de las tres es la NF1. Con una incidencia de 1 en 3000 y una penetrancia del 100% presenta amplio espectro de manifestaciones clínicas. Nosotros presentamos un caso de sexo femenino que consulta inicialmente por dolor relacionado a una lesión compatible con neuro fibroma con componente epidérmico y subcutáneo. Sin diagnóstico previo de la enfermedad a los 33 años, logramos la correspondiente captación de todos los integrantes de su familia quienes tampoco tenían diagnóstico.
Summary Neurofibromatosis is an autosomal dominant genodermatosis. The literature recognizes several different clinical syndromes within which three main forms are described: Neurofibromatosis type 1, Neurofibromatosis type 2 and Schwanomatosis. The most common of the three is NF1. With an incidence of 1 in 3000 and a penetrance of 100%, it presents a broad spectrum of clinical manifestations. We present a female case that initially consulted for pain related to a lesion compatible with neurofibroma with an epidermal and subcutaneous component. Without previous diagnosis of the disease at 33 years, we were able to diagnose all the members of his family, who also had no diagnosis.
ABSTRACT
Weight stigmatization is defined as the devaluation of others based on weight, a visible and specific characteristic that cannot be hidden. The consequences of weight stigmatization have been studied in victims and healthcare providers. This narrative literature review describes the consequences of weight stigmatization in victims and healthcare practitioners. According to several studies, high levels of psychological dysfunction in victims coexist with negative stereotypes in healthcare professionals, since the latter are exposed to the same negative media messages about obesity. Thus, weight stigmatization contributes to increase the burden of obesity, since when obese patients perceive that they are discriminated by healthcare professionals, their unhealthy behaviors persist and they have a low adherence to obesity treatment and medical recommendations.
Subject(s)
Humans , Attitude of Health Personnel , Social Stigma , Obesity/psychology , Social Discrimination/psychologyABSTRACT
Weight stigmatization is defined as the devaluation of others based on weight, a visible and specific characteristic that cannot be hidden. The consequences of weight stigmatization have been studied in victims and healthcare providers. This narrative literature review describes the consequences of weight stigmatization in victims and healthcare practitioners. According to several studies, high levels of psychological dysfunction in victims coexist with negative stereotypes in healthcare professionals, since the latter are exposed to the same negative media messages about obesity. Thus, weight stigmatization contributes to increase the burden of obesity, since when obese patients perceive that they are discriminated by healthcare professionals, their unhealthy behaviors persist and they have a low adherence to obesity treatment and medical recommendations.
Subject(s)
Attitude of Health Personnel , Obesity/psychology , Social Stigma , Humans , Social Discrimination/psychologyABSTRACT
ABSTRACT Leaf and stripe rusts, caused by Puccinia triticina and P. striiformis, respectively, are globally important fungal diseases of wheat that cause significant annual yield losses. A gene that confers slow rusting resistance to leaf rust, designated as Lr46, has recently been located on wheat chromosome 1B. The objectives of our study were to establish the precise genomic location of gene Lr46 using molecular approaches and to determine if there was an association of this locus with adult plant resistance to stripe rust. A population of 146 F(5) and F(6) lines produced from the cross of susceptible 'Avocet S' with resistant 'Pavon 76' was developed and classified for leaf rust and stripe rust severity for three seasons. Using patterns of segregation for the two diseases, we estimated that at least two genes with additive effects conferred resistance to leaf rust and three to four genes conferred resistance to stripe rust. Bulked segregant analysis and linkage mapping using amplified fragment length polymorphisms with the 'Avocet' x 'Pavon 76' population, F(3) progeny lines of a single chromosome recombinant line population from the cross 'Lalbahadur' x 'Lalbahadur (Pavon 1B)', and the International Triticeae Mapping Initiative population established the genomic location of Lr46 at the distal end of the long arm of wheat chromosome 1B. A gene that is closely linked to Lr46 and confers moderate levels of adult plant resistance to stripe rust is identified and designated as Yr29.
