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1.
Front Physiol ; 12: 771684, 2021.
Article in English | MEDLINE | ID: mdl-34803744

ABSTRACT

Purpose: The purpose of this study was to examine the effects of 15 weeks (2/week) of two different resistance training (RT) programs [the self-load group (SG) vs. the overload group (OG)] on selected measures of physical performance in young male soccer players. Methods: The countermovement jump (CMJ), aerobic endurance (VO2 max), and body composition [body mass (BM), height (H), body fat percentage (% BF), and lean mass (LM)] were measured before and after the 15-week RT interventions. Subjects were randomized to treatments: 1. SG [age = 15.34 ± 1.34 years]; 2. OG [age = 16.28 ± 1.21 years]. Results: The level of significance set for the study (p ≤ 0.05). Within-group analysis did report significant differences in all variables for the SG (p = 0.008 to 0.001; ES = -0.33 to 1.41, small to large) as in the OG (p = 0.001; ES = 0.82 to 1.30, large). Between-groups analysis reported differences in CMJ (F = 4.32; p = 0.004) for the OG. Conclusion: The main findings of this study indicated that RT with and without external load was effective in improving the measures of physical performance in young soccer players, with special attention to jumping ability, where the OG group was more effective. Furthermore, there is no interference to aerobic endurance. It is recommended that soccer coaches implement RT without external load in the early stages of training or in players with late maturation development and in those soccer clubs with limited material resources.

2.
Toxicol Appl Pharmacol ; 365: 124-132, 2019 02 15.
Article in English | MEDLINE | ID: mdl-30641074

ABSTRACT

Exposure to mine tailings dust from active and abandoned mining operations may be a very significant health hazard, especially to sensitive populations living in arid and semi-arid climates like the desert southwest of the US. It is anticipated that early life exposures during sensitive times of development can lead to adult disease. However, very few studies have investigated the effects of inhalation exposure to real world dusts during lung development. Using a mouse model, we have examined the effect(s) of inhalation of real world mine tailing dusts under three separate conditions: (1) Exposure only during in utero development (exposure of the pregnant moms) (2) exposure only after birth and (3) exposures that occurred continuously during in utero development, through gestation and birth until the mice reached adulthood (28 days old). We found that the most significant changes in lung structure and function were observed in male mice when exposure occurred continuously throughout development. These changes included increased airway hyper-reactivity, increased expression of epithelial to mesenchymal (EMT) transition protein markers and increased expression of cytokines related to eosinophils. The data also indicate that in utero exposures through maternal inhalation can prime the lung of male mice for more severe responses to subsequent postnatal exposures. This may be due to epigenetic alterations in gene regulation, immune response, molecular signaling, and growth factors involved in lung development that may make the neonatal lung more susceptible to continued dust exposure.


Subject(s)
Air Pollutants/toxicity , Dust , Inhalation Exposure/adverse effects , Lung Diseases/chemically induced , Lung/drug effects , Mining , Age Factors , Animals , Bronchial Hyperreactivity/chemically induced , Bronchial Hyperreactivity/physiopathology , Cytokines/metabolism , Eosinophils/drug effects , Eosinophils/metabolism , Eosinophils/pathology , Epithelial-Mesenchymal Transition/drug effects , Female , Gestational Age , Lung/metabolism , Lung/pathology , Lung/physiopathology , Lung Diseases/metabolism , Lung Diseases/pathology , Lung Diseases/physiopathology , Male , Mice, Inbred C57BL , Pregnancy , Prenatal Exposure Delayed Effects , Risk Assessment
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