ABSTRACT
CASO CLÍNICO: Presentamos 2 casos de síndrome de nefritis túbulo-intersticial y uveítis que necesitaron tratamiento con inmunosupresores para lograr el control de la uveítis. Al contrario de lo habitualmente descrito, la uveítis adquirió un carácter crónico, siendo necesario el tratamiento inmunosupresor. La nefritis sí respondió al tratamiento con corticoides. DISCUSIÓN: El síndrome de nefritis túbulo intersticial y uveítis constituye una condición infradiagnosticada que requiere un alto índice de sospecha diagnóstica, ya que no se acompaña de alteraciones específicas. La inflamación ocular cursa con frecuentes recurrencias, siendo necesario, en raras ocasiones, el tratamiento inmunosupreso
CASE REPORT: Two cases of tubulointerstitial nephritis and uveitis are presented. Immunosuppressive therapy was required to control the uveitis. Contrary to that usually described, uveitis became chronic, which made immunosuppressive therapy necessary. Nephritis was successfully treated with steroids. DISCUSSION: Tubulointerstitial nephritis and uveitis syndrome is an under-diagnosed disorder and requires clinical suspicion due to there being no specific laboratory study available. Recurrences and relapses of ocular inflammation are common. Immunosuppressive therapy is not often needed
Subject(s)
Humans , Female , Adolescent , Adult , Uveitis/drug therapy , Immunosuppressive Agents/therapeutic use , Nephritis, Interstitial/drug therapy , Adrenal Cortex Hormones/therapeutic use , Nephritis, Interstitial/complications , Uveitis/complications , Treatment OutcomeABSTRACT
CASE REPORT: Two cases of tubulointerstitial nephritis and uveitis are presented. Immunosuppressive therapy was required to control the uveitis. Contrary to that usually described, uveitis became chronic, which made immunosuppressive therapy necessary. Nephritis was successfully treated with steroids. DISCUSSION: Tubulointerstitial nephritis and uveitis syndrome is an under-diagnosed disorder and requires clinical suspicion due to there being no specific laboratory study available. Recurrences and relapses of ocular inflammation are common. Immunosuppressive therapy is not often needed.
Subject(s)
Immunosuppression Therapy , Nephritis, Interstitial/drug therapy , Uveitis/drug therapy , Adolescent , Adult , Female , HumansABSTRACT
Caso clínico: Presentamos el caso de un varón de 42 años de edad con varios episodios de uveítis unilateral en su ojo derecho. El examen oftalmológico mostró una uveítis anterior granulomatosa con vitritis. El estudio sistémico puso de manifiesto una proteinuria de rango no nefrótico y microhematuria. La biopsia renal reveló una nefropatía IgA. Discusión: Las uveítis y las glomerulonefritis podrían tener mecanismos inmunológicos comunes. En el diagnóstico diferencial de los pacientes con uveítis y nefropatías debería incluirse la nefropatía IgA (AU)
Case report: The case is presented of a 42 year-old man with episodes of unilateral uveitis in his right eye. Ophthalmic examination showed a granulomatous anterior uveitis with vitritis. Systemic investigations revealed non-nephrotic proteinuria and microhaematuria. A renal biopsy showed IgA nephropathy. Discussion: Uveitis and glomerulonephritis may have common immunological pathogenesis. IgA nephropathy should be a differential diagnosis in patients with uveitis and nephropathy (AU)
Subject(s)
Humans , Male , Adult , Uveitis/complications , Glomerulonephritis, IGA/complications , Diagnosis, Differential , Vitreous Body/physiopathology , Pars Planitis/complications , Proteinuria/etiologyABSTRACT
CASE REPORT: The case is presented of a 42 year-old man with episodes of unilateral uveitis in his right eye. Ophthalmic examination showed a granulomatous anterior uveitis with vitritis. Systemic investigations revealed non-nephrotic proteinuria and microhaematuria. A renal biopsy showed IgA nephropathy. DISCUSSION: Uveitis and glomerulonephritis may have common immunological pathogenesis. IgA nephropathy should be a differential diagnosis in patients with uveitis and nephropathy.
