Subject(s)
Exanthema , Psoriasis , Child , Humans , Peroxidase , Psoriasis/genetics , Mutation , Chronic DiseaseSubject(s)
Antineoplastic Agents , Carcinoma, Basal Cell , Skin Neoplasms , Humans , Carcinoma, Basal Cell/drug therapy , Carcinoma, Basal Cell/pathology , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Anilides/therapeutic use , Pyridines/therapeutic use , Antineoplastic Agents/therapeutic useSubject(s)
Melanoma , Melanosis , Skin Neoplasms , Humans , Melanoma/pathology , Melanosis/complications , Nivolumab/adverse effects , Skin Neoplasms/pathologySubject(s)
Humans , Male , Young Adult , Gangrene , Scrotum/surgery , Vasculitis/diagnosis , Diagnosis, DifferentialSubject(s)
Dermatitis, Allergic Contact/diagnosis , Gold Sodium Thiosulfate/adverse effects , Histiocytosis, Langerhans-Cell/diagnosis , Skin Tests/methods , Allergens/adverse effects , Dermatitis, Allergic Contact/etiology , Dermatitis, Allergic Contact/pathology , Female , Histiocytosis, Langerhans-Cell/chemically induced , Histiocytosis, Langerhans-Cell/pathology , Humans , Middle Aged , Patch Tests , Skin/pathology , Time FactorsSubject(s)
Atrial Fibrillation/drug therapy , Drug Eruptions/etiology , Rivaroxaban/adverse effects , Vasculitis, Leukocytoclastic, Cutaneous/chemically induced , Aged, 80 and over , Atrial Fibrillation/diagnosis , Biopsy, Needle , Drug Eruptions/pathology , Enoxaparin/therapeutic use , Female , Follow-Up Studies , Humans , Immunohistochemistry , Lower Extremity , Prednisone/therapeutic use , Risk Assessment , Rivaroxaban/therapeutic use , Treatment Outcome , Vasculitis, Leukocytoclastic, Cutaneous/drug therapy , Vasculitis, Leukocytoclastic, Cutaneous/pathologySubject(s)
Graft vs Host Disease/etiology , Skin Diseases/etiology , Stem Cell Transplantation/adverse effects , Acute Disease , Child , Female , Graft vs Host Disease/pathology , Humans , Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy , Skin Diseases/pathology , Striae Distensae/pathology , Transplantation, Homologous/adverse effectsABSTRACT
Viral-associated trichodysplasia spinulosa is an unusual condition with distinctive clinical and histopathological features. Initially described in patients immunosupressed as a result of solid organ transplantation, it has also been reported in patients treated with immunosuppressive drugs other than cyclosporine or being treated for hematological malignancies. Patients presented with disseminated follicular, hyperkeratotic papules, and variable degrees of alopecia. Histopathological examination revealed shaftless bulbous and dilated hair follicles with keratotic plugging of the infundibulum. The authors reported a case of viral-associated trichodysplasia in a 5-year-old boy treated for a lymphoblastic leukemia. Eruption persisted, although treated with emollients and keratolytics, but resolved spontaneously after completing the antineoplastic medication.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Hair Diseases/pathology , Hair Diseases/virology , Ichthyosis/pathology , Ichthyosis/virology , Polyomavirus Infections/immunology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Child, Preschool , Hair Diseases/immunology , Humans , Ichthyosis/immunology , Immunocompromised Host , Male , Mercaptopurine/administration & dosage , Mercaptopurine/adverse effects , Methotrexate/administration & dosage , Methotrexate/adverse effects , Polyomavirus Infections/complications , Polyomavirus Infections/pathologyABSTRACT
BACKGROUND: O'Brien described four histopathological patterns of actinic granuloma (AG). Since then, only single cases and a few series have been reported in the literature, most corresponding to cases of the giant cell type. METHODS: We reviewed all the cases diagnosed as AG or elastolytic giant cell granuloma (EGCG) in our department from 1988 until 2010. The biopsies were classified into the four patterns previously described. RESULTS: Giant cell pattern was found to be the most frequent (70% of the cases). In four cases, the biopsies showed more than one histopathologic pattern. All the lesions were located on sun-exposed areas or were related to chronic heat exposure. Diabetes mellitus was associated in 40 % of the cases. CONCLUSIONS: The giant cell pattern of EGCG is the most frequent. Some cases may share histopathologic features of more than one variant and thus, we consider they may be categorized as mixed patterns. Diabetes mellitus is the most common associated disease and should always be ruled out.
Subject(s)
Granuloma, Giant Cell/pathology , Skin Neoplasms/pathology , Adult , Age Distribution , Aged , Biopsy , Diabetes Complications , Extremities/pathology , Female , Granuloma, Giant Cell/complications , Humans , Male , Middle Aged , Sex Distribution , Skin Neoplasms/complicationsABSTRACT
We report two cases of systemic photosensitivity induced by simvastatin and pravastatin that presented as photodistributed erythema multiforme. One of them occurred in a 75-year-old woman who had been suffering recurrent eruptions following sun exposures over a period of 12 years. The other patient was a 54-year-old man who had a 1-week history of pruritic lesions on the face and the hands. They had no history of herpes simplex virus infection. In both cases, the close temporal relationship between drug ingestion and onset of the conditions suggested statin-induced photosensitivity. The diagnosis was confirmed by the marked reduction of UVB-MED or both UVA and UVB-MED while taking the drug and its normalization after discontinuing the statin intake.
Subject(s)
Erythema Multiforme/etiology , Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects , Ultraviolet Rays/adverse effects , Aged , Erythema Multiforme/chemically induced , Female , Humans , Male , Middle AgedABSTRACT
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