ABSTRACT
Brain ischaemia and reperfusion produce alterations in the microenvironment of the parenchyma, including ATP depletion, ionic homeostasis alterations, inflammation, release of multiple cytokines and abnormal release of neurotransmitters. As a consequence, the induction of proliferation and migration of neural stem cells is redirected towards the peri-infarct region. The success of new neurorestorative treatments for damaged brain implies the need to describe with greater accuracy the mechanisms in charge of regulating adult neurogenesis, under both physiological and pathological conditions. Recent evidence demonstrates that many neurotransmitters, glutamate in particular, control the subventricular zone (SVZ), thus being part of the complex signal network that exerts a remarkable influence on the production of new neurones. Neurotransmitters provide a link between brain activity and SVZ neurogenesis. Therefore, a deeper knowledge of the role of neurotransmitters systems, such as glutamate and its transporters, in adult neurogenesis, may prove a valuable tool to be utilized as a neurorestorative therapy in this pathology.
Subject(s)
Brain Ischemia/metabolism , Neurogenesis/physiology , Neurons/cytology , Neurotransmitter Agents/metabolism , Stroke/pathology , Animals , Brain Injuries/metabolism , Brain Injuries/pathology , Brain Ischemia/pathology , HumansABSTRACT
UNLABELLED: This work aimed to assess the utility of 99mTc-MIBI scintigraphy in the diagnosis and follow-up of lymphoma patients. Seventy-two patients with a previous diagnosis of lymphoma (41 with Hodgkin's and 31 with non-Hodgkin's disease) and a control group of 8 patients with palpable lymph nodes and a negative diagnosis of lymphoma based on the clinical examination, chest x-ray, lymphography, ultrasounds and biopsy were studied. Whole body scintigraphies were performed 20 min and 2 h after i.v. administration of 740 MBq of 99mTc-MIBI. The joint result of the already mentioned standard diagnostic tests was considered as the confirmation criterion. A sensitivity, specificity and accuracy of 96,2%, 100% and 97,4% respectively were obtained. Kappa coefficient was k = 0,94 +/- 0,11. CONCLUSION: Scintigraphy with 99mTc-MIBI is a useful tool for the diagnosis and follow-up of lymphomas regardless of their classification.
Subject(s)
Hodgkin Disease/diagnostic imaging , Lymphoma, Non-Hodgkin/diagnostic imaging , Technetium Tc 99m Sestamibi , Adolescent , Adult , Aged , Castleman Disease/diagnostic imaging , Child , Child, Preschool , Evaluation Studies as Topic , Female , Follow-Up Studies , Humans , Lymphadenitis/diagnostic imaging , Male , Middle Aged , Radionuclide Imaging , Sensitivity and SpecificityABSTRACT
El objetivo del presente trabajo fue evaluar la utilidad de la gammagrafía con 99mTc-metoxi-isobutil-isonitrilo (MIBI) en el diagnóstico y seguimiento de pacientes que padecen de linfoma. Se estudiaron 72 pacientes con diagnóstico de linfoma (41 Hodgkin y 31 no Hodgkin) y un grupo control de 8 pacientes con ganglios palpables y diagnóstico negativo de linfoma producto de la evaluación clínica, radiografía de tórax, linfografía, ultrasonido y la biopsia. Se realizaron rastreos gammagráficos 20 min y 2 h después de la administración i.v. de 740 MBq de 99mTc-MIBI. El resultado conjunto de los instrumentos diagnósticos antes señalados se tomó como criterio de confirmación. Se obtuvo una sensibilidad, especificidad y exactitud de 96,2 per cent, 100 per cent y 97,4 per cent respectivamente. El coeficiente Kappa fue de 0,94 ñ 0,11. Conclusión: La gammagrafía con 99mTc-MIBI es útil para el diagnóstico y seguimiento de los linfomas, independientemente de su clasificación (AU)
