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Paediatr Anaesth ; 16(2): 188-91, 2006 Feb.
Article in English | MEDLINE | ID: mdl-16430418

ABSTRACT

Glutaric aciduria type 1 (GA-1) is an inborn error of metabolism that results from a deficiency of glutaryl-CoA dehydrogenase. This disorder mainly manifests in early childhood and most patients with this condition develop a dystonic-dyskinetic syndrome. We report the anesthetic management of two sisters with GA-1, aged 30 and 17 months respectively at the time of surgery, who presented with macrocephaly and psychomotor delay. The children required CSF shunting procedures for hydrocephalus and subdural fluid collections, which were performed under total intravenous anesthesia with propofol and remifentanil.


Subject(s)
Anesthesia/methods , Anesthetics, Intravenous/administration & dosage , Glutarates/metabolism , Glutaryl-CoA Dehydrogenase/deficiency , Metabolism, Inborn Errors/surgery , Siblings , Anesthetics, Intravenous/adverse effects , Cerebrospinal Fluid Shunts/methods , Child, Preschool , Dystonic Disorders , Female , Head/abnormalities , Humans , Hydrocephalus/complications , Hydrocephalus/surgery , Infant , Metabolism, Inborn Errors/complications , Metabolism, Inborn Errors/genetics , Piperidines/administration & dosage , Piperidines/adverse effects , Propofol/administration & dosage , Propofol/adverse effects , Psychomotor Disorders/complications , Remifentanil
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