ABSTRACT
OBJECTIVES: To determine the possible antiemetic effect of propofol as the single agent for intravenous anesthesia in children undergoing strabismus surgery, in comparison with other techniques. PATIENTS AND METHOD: Eighty ASA I and II patients between 3 and 10 years, divided into 4 groups of 20, were studied prospectively. Groups I, II and III were premedicated with dehydrobenzylperidol (90 micrograms/kg) i.m. Group I then received sleep doses of thiopental and N2O. Group II received propofol, sleep doses, and N2O. Groups III and IV received sleep doses of propofol followed by intravenous perfusion (10 mg/kg/h). RESULTS: Half the patients in group I experienced postoperative vomiting, more than in groups II, III and IV (p < 0.05). The incidence of vomiting in group II was 30%. Groups III and IV experienced less vomiting (5-10%) than did groups I and II (p < 0.05). The incidence of bradycardia during surgery was higher in groups III and IV (p < 0.05); medical treatment was not required. CONCLUSIONS: Propofol used as the single agent for induction and maintenance of anesthesia offers clear advantages in reducing emesis after strabismus surgery.
Subject(s)
Anesthetics, Intravenous/therapeutic use , Postoperative Complications/prevention & control , Propofol/therapeutic use , Vomiting/prevention & control , Child , Child, Preschool , Female , Humans , Infusions, Intravenous , Male , Prospective Studies , Strabismus/surgeryABSTRACT
The effects of hyperthermia, injection of endotoxin and different antipyretics on serum iron levels in rabbits have been determined. Three antipyretics, Ketoprofen (K), Indomethacin (I), and Polymyxin B (P) induced a rise in serum iron concentration. The rise in serum levels induced by Ketoprofen seems to be related to the half life of the compound. Pretreatment with these antipyretics inhibits the rise in body temperature and the fall in serum concentration observed after the administration of bacterial endotoxin. The hyperthermia failed to modify serum iron levels.
