ABSTRACT
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic debilitating autoinflammatory skin disease. Adalimumab is the only biologic agent available to treat HS, but lack of response is observed in some patients. Ustekinumab may be useful to treat patients with HS who do not respond to adalimumab. OBJECTIVE: The objectives of this study were: (1) to retrospectively evaluate the therapeutic outcomes of ustekinumab in a multicenter series of patients with HS and (2) to assess all published scientific evidence on its utilization in patients with HS. METHODS: We evaluated the therapeutic outcomes of 10 patients with HS treated with ustekinumab and conducted a systematic review of published epidemiological studies on ustekinumab-treated patients with HS. RESULTS: In the case series, an improvement in the Physician Global Assessment score was observed in 70% (7/10) patients and an improvement in the Numerical Pain Rating Scale in 80% (8/10). In the systematic review, clinical improvement in disease severity was reported in 76% (34/45) patients and symptomatic improvement in 84% (38/45). No severe ustekinumab-related adverse event was recorded. CONCLUSION: These findings suggest that ustekinumab may be an effective and safe option for patients with HS who fail to respond to first-line therapies.
Subject(s)
Hidradenitis Suppurativa , Ustekinumab , Adalimumab/therapeutic use , Hidradenitis Suppurativa/drug therapy , Humans , Multicenter Studies as Topic , Retrospective Studies , Severity of Illness Index , Ustekinumab/therapeutic useABSTRACT
El Sarcoma de Kaposi es un tumor vascular de origen multifocal que se relaciona con el virus herpes humano tipo 8. La afectación genital en el sarcomade Kaposi es rara sobretodo en pacientes VIH negativo. Las lesiones en este área muestran rasgos clínicos e histológicos similares a otras localizaciones,sin embargo, es interesante el diagnóstico diferencial con otras enfermedades que presentan lesiones genitales. Presentamos un caso de sarcoma deKaposi clásico localizado exclusivamente en pene (AU)
Kaposis sarcoma is a multifocal vascular tumor which is related to human herpes virus type 8. The genital involvement in Kaposis sarcoma is infrequentmostly in HIV - patients. Lesions in this area show similar clinical and histological features as Kaposis sarcoma lesions in other locations. However,the differential diagnosis is interesting taking into account other dermatological conditions than present with genital lesions. We report a case ofclassic Kaposis sarcoma located in the penis (AU)
Subject(s)
Humans , Male , Middle Aged , Penile Neoplasms/diagnosis , Sarcoma, Kaposi/diagnosis , Penile Neoplasms/pathology , Penile Neoplasms/radiotherapy , Sarcoma, Kaposi/pathology , /radiotherapy , Herpesvirus 8, Human/isolation & purification , Penile Neoplasms/virology , Sarcoma, Kaposi/virology , Diagnosis, DifferentialABSTRACT
The terms verrucous hemangioma and angiokeratoma circumscriptum have been used interchangeably in the literature to define clinically similar lesions. From a histologic perspective, however, angiokeratoma circumscriptum is limited to the papillary dermis whereas verrucous hemangioma extends as far as the hypodermis. We describe the case of a 38-year-old woman who consulted for a lesion on the right thigh that was initially diagnosed as angiokeratoma; magnetic resonance imaging, however, led to a final diagnosis of verrucous hemangioma.
Subject(s)
Hemangioma/diagnosis , Magnetic Resonance Imaging , Adult , Female , Hemangioma/pathology , Humans , Skin Neoplasms/diagnosis , Skin Neoplasms/pathologyABSTRACT
Los términos hemangioma verrugoso y angioqueratoma circunscrito han sido utilizados en la literatura de manera indistinta para definir lesiones clínicamente similares; sin embargo, desde un punto de vista histológico, el angioqueratoma circunscrito se limita a la dermis papilar, mientras que el hemangioma verrugoso se extiende hasta la hipodermis. Presentamos el caso de una mujer de 38 años que consultó por una lesión en el muslo derecho que fue inicialmente diagnosticada de angioqueratoma; sin embargo, tras la realización de una resonancia magnética nuclear se llegó a un diagnóstico final de hemangioma verrugoso (AU)
The terms verrucous hemangioma and angiokeratoma circumscriptum have been used interchange ablyin the literature to define clinically similar lesions. From a histologic perspective, however, angiokeratoma circumscriptumis limited to the papillary dermis whereas verrucous hemangioma extends as far as the hypodermis. We describe the case of a 38-year-old woman who consulted for a lesion on the right thigh that was initially diagnosed as angiokeratoma; magnetic resonance imaging, however, led to a final diagnosis of verrucous hemangioma (AU)
