ABSTRACT
El carcinoma de células en anillo de sello primario de mama es un tumor infrecuente de histogénesis con-trovertida, de comportamiento agresivo y patrón metastásico inusual hacia el tracto gastrointestinal y superficies serosas, planteando problemas de diagnóstico diferencial con metástasis de carcinoma de células en anillo de sello de otros orígenes, preferentemente gastrointestinal. El perfil inmunohistoquímico con positividad para Citoqueratina 7 y para GCDFP-15 (Gross cystic disease fluid protein-15), y en ocasiones para los receptores hormonales, y negatividad para Citoqueratina 20, posibilita el diagnóstico diferencial con estos tumores. Presentamos un caso de carcinoma de células en anillo de sello primario de mama en una mujer de 72 años con gran masa tumoral en mama derecha, de varios meses de evolución, y revisamos la literatura sobre su histogénesis y el perfil inmunohistoquímico diferencial (AU)
Subject(s)
Aged , Female , Humans , Immunohistochemistry/methods , Carcinoma, Signet Ring Cell/immunology , Breast Neoplasms/immunology , Diagnosis, Differential , Mastectomy , Biomarkers, Tumor/analysis , Adenocarcinoma, Mucinous/immunologyABSTRACT
Intracortical osteosarcoma (IO) is the rarest form of osteosarcoma. A 19-year-old man had one of these lesions in the upper diaphysis of the femur. Microscopically, IO was a well-differentiated osteosarcoma with an osteoblastic histologic pattern. The typical location in the diaphysis and the peculiar histologic and roentgenographic findings with intracortical origin clearly separate this entity from conventional osteosarcomas as well as periosteal and parosteal osteosarcomas. IO are lytic neoplasms confined to the cortex of the diaphysis with a benign roentgenographic appearance, but are included in the differential diagnosis of benign tumors.
Subject(s)
Femoral Neoplasms/pathology , Osteosarcoma/pathology , Adult , Femoral Neoplasms/diagnostic imaging , Femoral Neoplasms/surgery , Humans , Male , Osteosarcoma/diagnostic imaging , Osteosarcoma/surgery , Tomography, X-Ray ComputedABSTRACT
The existence of thromboangiitis obliterans has been questioned for some years. However, it is now accepted as a specific condition within the wide group of vasculitis. We report a patient with this condition, who, as usual, was a male smoker. The illness presented with thrombophlebitis migrans, which is an uncommon initial feature. The patient also had small vessel cutaneous vasculitis, which is an extremely uncommon association. We report the case and discuss some aspects of the etiology and pathogenesis of the disease.
