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The role of memory-related gene polymorphisms, KIBRA and CLSTN2, on replicate memory assessment in the elderly.

Sédille-Mostafaie, N; Sebesta, C; Huber, K R; Zehetmayer, S; Jungwirth, S; Tragl, K H; Fischer, P; Krugluger, W.

J Neural Transm (Vienna) ; 119(1): 77-80, 2012 Jan.

Article in English | MEDLINE | ID: mdl-21643791

ABSTRACT

The role of the CLSTN2 (rs6439886) and KIBRA (rs17070145) SNPs in cognitive impairment was analysed in a 75-76 years old group. Various memory assessment tests were carried out on individuals at baseline and during follow-up investigations, and biallelic genotyping was performed. No influence of the allele status of either SNPs was observed on any memory test. No increased risk of any type of late development, and cognitive impairment was associated with rs6439886 or rs17070145.

Subject(s)

Aging/genetics , Calcium-Binding Proteins/genetics , Cognitive Dysfunction/genetics , Intracellular Signaling Peptides and Proteins/genetics , Membrane Proteins/genetics , Memory , Phosphoproteins/genetics , Polymorphism, Single Nucleotide/genetics , Aged , Alzheimer Disease/diagnosis , Austria , Female , Follow-Up Studies , Genotype , Humans , Male , Neuropsychological Tests

ABSTRACT

Subject(s)

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