Blood glucose and plasma insulin responses to various carbohydrates in type 2 (non-insulin-dependent) diabetes.

The blood glucose and plasma insulin responses to some simple carbohydrates (glucose, fructose, lactose) and some complex ones (apples, potatoes, bread, rice, carrots and honey) were studied in 32 Type 2 (non-insulin-dependent) diabetic patients. Blood glucose and plasma insulin were measured at zero time and then at 15, 30, 60, 90 and 120 min after ingestion of 25 g glucose, fructose or lactose, or 30 g honey, 50 g white bread, 125 g white rice or potatoes, 150 g apples or 260 g carrots. Maximum blood glucose and plasma insulin responses were recorded 60 min after ingestion of each test meal. At this time the increases in blood glucose and in plasma insulin were significantly higher after the more refined carbohydrates (glucose, fructose and lactose) than after the more complex ones (apples, potatoes, rice, carrots and honey, -p less than 0.01). Counting the blood glucose increase after glucose as 100%, the corresponding increases in glycaemia for other carbohydrates were: fructose, 81.3%; lactose, 68.6%; apples, 46.9%; potatoes, 41.4%; bread, 36.3%; rice, 33.8%; honey, 32.4% and carrots, 16.1%.

Behaviour of insulin antibodies in diabetics treated with different insulins.

Determinations of insulin antibodies in 116 insulin-dependent diabetics treated successively with various types on insulin and in a group of 55 diabetics who received a single insulin type from the onset of the disease, revealed higher titers in those under treatment with conventional insulins, particularly Insulin Novo Lente. The mean titer of insulin antibodies is considered to be related to the insulin demands and sometimes to the length of disease. The presence of antibodies was also recorded after administration of highly purified insulins, but much more seldom and with lower titers, which could be an argument for a wider utilization of such products.