Impaired metabolic control and socio-demographic status in immigrant children at onset of Type 1 diabetes.

AIM: The aim of the present study was to compare clinical and socio-demographic conditions at the onset of Type 1 diabetes in children born to immigrant families and children born to Swedish families, and to assess whether those conditions had an impact on metabolic status. METHODS AND DESIGN: This was an observational nationwide population-based matched cohort study on prospectively recorded registry data of all children with diabetes in Sweden and their families during 2000-2010. Out of a total of 13 415 children from the Swedish Childhood Diabetes Registry (SWEDIABKIDS), 879 children born to immigrant parents were collected. To these we added 2627 children with Swedish-born parents, matched for gender, age and year of onset of Type 1 diabetes. RESULTS: The proportion of low capillary pH (< 7.30) at onset was higher in the immigrant cohort [25.8% vs. 16.4% in the Swedish cohort (P < 0.001)]. HbA1c was also higher [95 mmol/mol (10.8%) vs. 88 mmol/mol (10.2%), respectively (P < 0.001)]. In a logistic regression model with low pH as the dependent variable, we were unable to reveal any significant association to socio-demographic factors, but the odds ratio for HbA1c was 0.983 (95% CI 0.976-0.991) and for plasma glucose was 0.953 (95% CI 0.933-0.973). CONCLUSION: Children born to immigrant parents have lower capillary pH and higher HbA1c at diabetes onset. Immigrant families harbour lower socio-demographic living conditions, but this fact does not seem to influence the inferior metabolic condition at diabetes onset.

Urinary and faecal incontinence: a population-based study.

AIM: To investigate the coexistence of urine and faecal incontinence in Swedish schoolchildren. METHODS: Cohort study of all schoolchildren in the first and fourth grades in the city of Eskilstuna. A questionnaire was used, in which parents reported the prevalence of urine and faecal incontinence for their children. with a response rate of 67%. Data were analysed with multiple logistic regression. RESULTS: Daytime urinary incontinence (at least once a month) was reported in 6.3% of the first graders and 4.3% of the fourth graders, while bedwetting (at least once a month) was reported in 7.1% and 2.7% and faecal incontinence in 9.8% and 5.6%, respectively. Daytime urinary incontinence was strongly associated with faecal incontinence; adjusted odds ratio (OR) 7.2 (p < 0.001) as well as with bedwetting; OR 4.1 (p < 0.001), whereas faecal incontinence and bedwetting lacked a significant association (OR 1.2). CONCLUSION: This study demonstrates that soiling and daytime urinary incontinence often coexist in Swedish schoolchildren. Collaborative treatment strategies with gastroenterological and urological content need to be developed for these children.

Orthodontic and surgical treatment of unilateral condylar hyperplasia during growth--a case report.

A 9-year-old boy was diagnosed as having an unilateral cross-bite with mandibular deviation. This was later found to be due to unilateral hyperplasia of the right condyle. The increased growth activity subsequently led to an extreme facial asymmetry and a serious psychological condition began to develop. Consequently, surgery was performed at the age of 11 years 8 months when removal of the enlarged condyle and an oblique ramus osteotomy on the opposite side was performed. In this way the facial asymmetry was eliminated. No effort during the surgery was made, however, to restore normal occlusion. The post-operative orthodontic treatment was successful in allowing growth to bring about a normalization of the occlusal relationships. Two years after surgery, complete aesthetic and function rehabilitation has been achieved. This has also led to an improvement in the patient's psychological condition. The result was still stable 11 years post-operatively. The case illustrates the value of early treatment and co-operation between orthodontists and oral surgeons.

Antitubulin activity of vinblastine and vincristine. Clinical implications of the radial segmentation test.

The antitubulin activity of vinblastine and vincristine was compared by means of the radial segmentation test. Vinblastine was found to have antitubulin activity at least 6 times higher than that of vincristine. It is concluded that, if the differential indications for vinblastine or vincristine are balanced, it may be decisive for clinical treatment that more antitubulin activity can be administered as vinblastine than as vincristine.

Cytochalasin B partially inhibits the oxalate-induced radial segmentation of mononucleated blood cells.

Cytochalasin B (CB), 5 microgram/ml (= 1.0 x 10(-5) M), inhibited the oxalate-induced radial segmentation of the nuclei of lymphocytes and monocytes from peripheral blood. The median inhibition was 60%. The oxalate-induced radial segmentation (RS) is thought to be due to a microtubule-dependent contraction of the intermitotic residue of the mitotic apparatus around the nucleus. CB is thought to inhibit cell locomotion and cytokinesis by a centripetal contraction of the membrane-associated contractile cell layer without subsequent relaxation. It is thus suggested that the CB inhibition of the oxalate-induced RS was due to a spatial interference of the CB-induced contraction with the formation of RS nuclei.

The oxalate-induced radial segmentation of the nuclei in peripheral blood lymphocytes of different size.

The incidence of oxalate-induced radial-segmented (RS) nuclei in lymphocytes from peripheral blood correlated closely with the diameter of the cell and with the diameter of the nucleus; the majority of RS nuclei were found in large lymphocytes. This observation supports the basic hypotheses, that large lymphocytes from peripheral blood represent a later stage in the cell cycle than small lymphocytes, that the tubulin content of lymphocytes increases during the interphase and that the incidence of RS nuclei reflects the tubulin content of the cells within the various size classes.