Isolation of the isopropanol extract components of the leaves of Ailanthus glandulosa by a new method.

The leaves of Ailanthus glandulosa were extracted with the Soxhlet apparatus using isopropanol. A new method was used to separate and isolate eleven chemical compounds present in the leaves of bird's tongue. The separation was carried out by column chromatography using displacement solvents (petroleum ether, chloroform, dichloromethane, methanol) and four eluates were obtained. The four eluates were treated with a number of solvents, yielding thirty-four compounds. The chemical content of the mordants was determined using GC/MS technology. The samples tested contained six ester compounds, three aldehyde compounds, three ketone compounds, two alcoholic compounds, eight carboxylic acid compounds, five silicone compounds, five aromatic compounds and one phosphate compound. Eleven compounds were isolated, the most important of which are: 2-naphthoxyacetic acid, 2,6-bis (1,1-dimethylethyl)-4-ethylphenol, 2,5-tert-butylnitrobenzene, 5-hexyl-2-furaldehyde, 16-nitrobicyclo [10.4.0] hexadecan-1-ol-13-one, cyclooctasiloxan hexadecamethyl.

Synthesis of new flavonoid derivatives based on 3-hydroxy-4'-dimethylamino flavone and study the activity of some of them as antifungal.

Chalcone was prepared in a new route by reacting o-hydroxyacetophenone with 4-dimethylaminobenzaldehyde using piperidine as a catalyst. 3-Hydroxy-2-[4-(dimethylamino)phenyl] benzopyran-4-one were prepared by Algar-Flynn-Oyamada method by cyclization of chalcone using Hydrogen peroxide. A series of alkyl and ester derivatives of the flavonoid 3-hydroxy-2-[4-(dimethylamino)phenyl] benzopyran-4-one were prepared by reacting the above mentioned compound with different chemical reagents (Methyl iodide, Allyl bromide, Benzyl chloride, Bromoacetylcoumarin, Chloroacetamide, Chloroacetyl chloride, Phthalic anhydride, Maleic anhydride, Phthalimide, Cinnamoyl chloride) with potassium carbonate and acetone or DMF as a solvent. The physical and spectroscopic properties of the new compounds were studied by (FT-IR, 13C-NMR and 1H-NMR) spectral methods. The purity of the synthesized compounds were confirmed using TLC thin layer chromatography. The biological activity of some synthetic flavonoids (A2, A5, A7, A8, A9, A12) at two different concentrations (0.5 mg/ml, 0.25 mg/ml) were studied on three types of fungi: Aspergillus flavus, Acremonium strictum, Penicillium expansum. Some of this compounds showed high activity against the tested fungi.