ABSTRACT
The research was conducted with participation of the perlite production workers with professional eczema (165 people in the main group and 152 from the control group without skin pathology). The effectiveness of the use of a specialized prophylactic food in the diet of workers was assessed on the basis of the study of the dynamics of the indicators of nutritional and clinical status. Inclusion of kissel, containing pectin, vitamin A (300% from RDA), vitamin E and zinc (40% from RDA), biologically active substances of plant origin in the diet of the examined against the background of the course of complex therapy, has resulted in a positive influence on individual laboratory values, demonstrating the optimization of metabolic processes, which characterize the pathogenesis of skin inflammation. Thus, the concentration of ascorbic acid in blood serum statistically significant (p<0.05) increased by 30.0%, tocopherol - by 36.3%, carotenoids - by 27.3%, phosphorus - by 28.9%, calcium level elevated by 16.3% (p<0.10). There was a decrease in the level of MDA in blood serum by 12.3% (p<0.05) and an increase in catalase activity by 12.2% (p>0.05). There was a tendency to reduce itching, infiltration, erythematous and eczematous manifestations of the disease. The data obtained make it possible to consider the use of a specialized food product of dietary preventive nutrition by workers in pearlite production as a mean to enhance the body's adaptive reserves and to prevent the occurrence, progression and development of occupational skin diseases (eczema) in the workplace.
Subject(s)
Aluminum Oxide/adverse effects , Chemical Industry , Eczema , Food Analysis , Foods, Specialized , Nutritional Status , Occupational Exposure/adverse effects , Silicon Dioxide/adverse effects , Eczema/blood , Eczema/chemically induced , Eczema/diet therapy , Humans , Male , Middle AgedABSTRACT
Comparative evaluation of clinical, neurophysiologic and laboratory data changes in 154 workers exposed to vibration in mining industry helped to identify the most informative criteria of vibration disease diagnosis. Scientifically justified use of neurospecific parameters - S100B protein and neurospecific enolase - was aimed to evaluate vibration disease severity.
Subject(s)
Mining , Occupational Diseases , Phosphopyruvate Hydratase/analysis , Polyneuropathies , S100 Calcium Binding Protein beta Subunit/analysis , Vibration/adverse effects , Biomarkers/analysis , Humans , Male , Middle Aged , Neurophysiology/methods , Occupational Diseases/diagnosis , Occupational Diseases/etiology , Occupational Diseases/metabolism , Occupational Exposure/adverse effects , Occupational Exposure/analysis , Polyneuropathies/diagnosis , Polyneuropathies/etiology , Polyneuropathies/metabolism , Severity of Illness IndexABSTRACT
The article covers results of study concerning metabolic processes in workers exposed to vibration. Findings are lipid peroxidation processes activation, depressed anti-oxidant system, changes in intracellular exchange processes, dependence of the studied parameters change on length of service with vibration exposure.
Subject(s)
Hand-Arm Vibration Syndrome/metabolism , Oxidative Stress , Vibration/adverse effects , Adult , Hand-Arm Vibration Syndrome/diagnosis , Humans , Lipid Peroxidation , Male , Middle Aged , Occupational Exposure/adverse effects , Occupational Exposure/analysis , Time FactorsABSTRACT
There are considered features of disorders of the immune response in chronic exposure to dust aerosols. The detected changes of indices of the immune status of employees of the dust dangerous occupations and patients with chronic dust pathology of the lungs were unidirectional in the character, which is probably caused by manifestations of nonspecific response of the immune system to the dust factor. The deterioration of cellular immunity, humoral immunity and cytokine profile predisposes to the occurrence of immunopathologic states, contributing to the development of caused by both worksite and occupation pathology.
Subject(s)
Aerosols , Air Pollutants, Occupational , Occupational Diseases , Occupational Exposure , Adaptation, Physiological/immunology , Adult , Aerosols/adverse effects , Aerosols/analysis , Air Pollutants, Occupational/adverse effects , Air Pollutants, Occupational/analysis , Cytokines/blood , Dust/analysis , Dust/prevention & control , Humans , Inhalation Exposure/adverse effects , Inhalation Exposure/analysis , Inhalation Exposure/prevention & control , Lymphocyte Subsets , Male , Middle Aged , Monitoring, Immunologic/methods , Monitoring, Immunologic/statistics & numerical data , Occupational Diseases/diagnosis , Occupational Diseases/etiology , Occupational Diseases/immunology , Occupational Diseases/prevention & control , Occupational Exposure/adverse effects , Occupational Exposure/analysis , Occupational Exposure/prevention & control , Occupational Health , Russia/epidemiology , Statistics as Topic , TimeABSTRACT
The article presents study results that demonstrate chronic fatigue syndrome in patients with vibration disease. Clinical manifestations of chronic fatigue syndrome are characterized by changes in the emotional-volitional and cognitive areas. Application of nootropic drug cortexin increases the efficiency of rehabilitation in patients with vibration disease with chronic fatigue syndrome.
Subject(s)
Fatigue Syndrome, Chronic/etiology , Hand-Arm Vibration Syndrome/complications , Occupational Exposure/adverse effects , Vibration/adverse effects , Adult , Cognition/physiology , Cytokines/blood , Emotions , Fatigue Syndrome, Chronic/epidemiology , Fatigue Syndrome, Chronic/immunology , Fatigue Syndrome, Chronic/psychology , Hand-Arm Vibration Syndrome/epidemiology , Hand-Arm Vibration Syndrome/immunology , Hand-Arm Vibration Syndrome/psychology , Humans , Male , Middle Aged , Neuropsychological Tests , Occupational Exposure/analysis , Russia , Severity of Illness IndexABSTRACT
The authors studied immune state of workers engaged in cement production. Ambivalent changes of immune parameters in apparently healthy workers depict various stages of adaptational protective reactions in body system. The studies support gradual changes in immune system under continued influence of occupational factors.
Subject(s)
Construction Industry , Construction Materials/adverse effects , Immunologic Deficiency Syndromes , Occupational Diseases/immunology , Occupational Exposure/adverse effects , Adult , Construction Industry/standards , Hematologic Tests , Humans , Immunologic Deficiency Syndromes/etiology , Immunologic Deficiency Syndromes/immunology , Male , Middle Aged , Russia , Time Factors , Workforce , Young AdultABSTRACT
The question to include locomotory disorders into set of symptoms of vibration disease due to local vibration is discussed over years. Studies of clinical symptoms of vibration disease in machinery construction workers demonstrated that bone and joint changes risk depends on intensity of vibration factor and length of exposure to local vibration, as well as on work hardiness. The authors specified X-ray criteria of bone and joint disorders and laboratory markers of bone tissue injury under exposure to local vibration.
Subject(s)
Hand-Arm Vibration Syndrome/pathology , Hand-Arm Vibration Syndrome/physiopathology , Joints/pathology , Joints/physiopathology , Upper Extremity/pathology , Upper Extremity/physiopathology , Female , HumansABSTRACT
The authors reviewed literature on molecular aspects of vibration effects in workers. Findings are that apparently healthy workers demonstrate changes in oxidative metabolism, rheological properties of blood, increased RBC membrane permeability, higher urinary level of substances characterizing muscular and connective tissues dystrophy.
Subject(s)
Connective Tissue/metabolism , Energy Metabolism/physiology , Immunity/physiology , Muscle, Skeletal/metabolism , Occupational Diseases/metabolism , Oxidative Stress/physiology , Vibration/adverse effects , Humans , Occupational Diseases/immunology , Occupational Exposure/adverse effectsABSTRACT
The article covers up-to-date state of work conditions, occupational and general morbidity in workers of metal mining enterprises situated in contrast climate regions of Russian Federation. The authors revealed peculiarities of functional state in metal mining workers of Arctic and European Russia.
Subject(s)
Health Status , Mining/standards , Occupational Diseases/epidemiology , Occupational Health , Humans , Metals , Morbidity/trends , Russia/epidemiologyABSTRACT
Miners of basic professions employed in contemporary metal mining industry are exposed to a range of industrial factors, such as vibration, noise, dustiness, and unfavorable microclimate. Long-term exposure to these factors is hazardous to their health, which is manifested by elevated general and occupational morbidity and a higher rate of biological aging. This is most typical of Far North miners, who are exposed to the combination of the industrial factors and extremal climate and geographic conditions. Research into the health status of miners engaged to underground works and open excavations in regions with contrasting climate and geographic conditions, allowed determination of main industrial risk factors (vibration and noise), leading occupational diseases and groups of high risk of their development (according to the occupation and the length of service). The study found high risk of cardivascular diseases as well as pathology of the musculoskeletal system, which was highest in miners in Norilsk region.
