ABSTRACT
The results of our follow-up studies show that; Active methods of treatment have improved the direct results of treatment for schizophrenics distinctly; the number of cured patients has increased three to four-fold, and the number of patients who are immune to treatment has even diminished by factor of 10. The results of active methods of treatment are not stable in the long term; in the course of our observations the number of cured decreased and the number of severely ill increased. Despite the inadequate stability of the cures resulting from treatment, the long-term prognosis is better for those who received active treatment than for those treated passively. Schizophrenics treated with insulin during their first term of hospitalization have a better chance of being cured permanently. The results presented here show that clearly differentiated indications must be elaborated for all methods currently used to treat schizophrenia in order to obtain optimum results.
Subject(s)
Schizophrenia/therapy , Schizophrenic Psychology , Adult , Antipsychotic Agents/therapeutic use , Combined Modality Therapy , Convulsive Therapy , Electroconvulsive Therapy , Female , Follow-Up Studies , Humans , Male , Social AdjustmentABSTRACT
In 15 normal volunteers the action of succinic semialdehyde (SSA), and in 24 volunteers the effect of sodium succinate (SS), on the HNA have been investigated. As a result it was found that SSA brings about some enhancement of the excitatory process in cortical - mainly verbal -activities, accompanied by subjective improvement of memory and concentration. In the other hand, the administration of SS improves the stability of cortical excitatory process and its equilibrium with cortical inhibition; and enhances the connecting activity of the verbal system. These changes parallel the subjective elevation of mood and of general tone. In the basis of this study, one may suggest that succinic acid may be a psychoenergizer. The task of further investigations is to establish the range of therapeutic activity of these compounds.
