Assessment of the effectiveness of Saba shielding with the composition of Cu-Bi in neck CT imaging: a phantom and patient study.

The use of computed tomography (CT) is a very well-established medical diagnostic imaging modality, however, the high radiation dose due to this imaging method is a major concern. Therefore, dose reduction methods are necessary, especially for superficial radiosensitive organs like the thyroid. The aim of this study is to construct and assess a CT shield with composition of 90% Cu and 10% Bi (Saba shield) with regard to dose reduction and image quality. The efficiency of the constructed shields for dose reduction was assessed by measuring entrance skin dose (ESD), using thermoluminescence dosimeters placed on an anthropomorphic phantom. Image quality was assessed quantitatively based on image noise and CT number accuracy by drawing regions of interest on CT images of the anthropomorphic phantom. Image quality was further investigated qualitatively in a patient study. Application of the Saba shield and 100% Bi shield with the thickness of one thickness (1T) reduced ESD by 50.2% and 51.7%, respectively, and using a three-fold thickness reduced ESD by 64.6% and 65.1%, respectively. Saba shield with thickness of 1T had no significant change in image noise in the anterior part, and image noise and mean CT number in the posterior part (P> 0.05). The statistical analysis performed did not find any meaningful difference between the study and control groups in image quality assessment of the patient study (P> 0.05). The 1T Saba shield reduced thyroid dose efficiently during neck CT imaging without causing unwanted effects on image quality.

REDUCING ABSORBED DOSE TO THYROID IN NECK CT EXAMINATIONS: THE EFFECTS OF SABA SHIELDING.

Bi shielding has been used for the protection of radiosensitive organs during computed tomography (CT) for 20 years. In 2017, American Association of Physicists in Medicine recommended against Bi shielding due to its degrading effects on image quality. Saba shielding introduced recently protecting organs as Bi shielding without degrading image quality. In this study, the Saba shield was modified and primary radiation attenuation values of the shields and entrance skin dose (ESD) on the thyroid were measured with and without shielding. Furthermore, the quality of images obtained using Saba shielding was investigated quantitatively and qualitatively. Saba and Bi shielding reduced the ESD on the thyroid by about 50%. Saba shielding had about 5-7 HU less noise and about 51-65 HU less CT numbers shift in comparison with Bi shielding at a distance of 1 cm from the shields. Saba shielding had no degrading effects on image quality in the patient study.

Grape seed extract alleviates radiation-induced damages in human blood lymphocytes.

OBJECTIVE: Ionizing radiation induces deleterious effects in the biological systems by producing free radicals. Grape Seed Extract (GSE) as a free radical scavenger could protect the body against the damages. MATERIALS AND METHODS: In this study, 12 healthy male volunteers were divided into Groups 1, 2, 3 and 4 and received 100, 300, 600 and 1000 mg GSE, respectively. Peripheral blood samples were collected from each volunteer 15 min before, and 1, 2, and 5 hr after GSE oral administration. Blood samples were then irradiated with 150 cGy of 100 kvp X-ray (Irradiated control group, was treated with only 1.5 Gy of X-rays). Cytogenic damages were detected by micronucleus assay. RESULTS: Results showed that irradiation significantly increased the incidence of micronuclei (p<0. 001). In group 1, the mean reduction of micronucleus rate was 26.53%, 34.92%, and 31.38%, 1, 2, and 5 hr after GSE ingestion (p<0.001), respectively; this variable in group 2 was 17.38, 38.33, and 31.38 (p<0. 001), in group 3, was 35.65%, 46%, and 37.15% (p<0.001), respectively and in group 4, was 41.35%, 51.73%, and 50.55% (p<0.0001), respectively. The samples collected 1, 2, and 5 hr after ingestion of GSE exhibited a significant decrease in the incidence of micronuclei compared with the radiation control group. The maximum protection and reduction in frequency of micronuclei (51.73%) was observed 2 hr after ingestion of 1000 mg GSE. CONCLUSION: Consumption of GSE before undergoing radiation protects human lymphocytes against X-rays by reducing radiation-induced genotoxicity.

A nonlinear dynamical approach to analysis of emotions using EEG signals based on the Poincaré map function and recurrence plots.

Dynamic variations of electroencephalogram (EEG) contain significant information in the study of human emotional states. Transient time methods are well suited to evaluate short-term dynamic changes in brain activity. Human affective states, however, can be more appropriately analyzed using chaotic dynamical techniques, in which temporal variations are considered over longer durations. In this study, we have applied two different recurrence-based chaotic schemes, namely the Poincaré map function and recurrence plots (RPs), to analyze the long-term dynamics of EEG signals associated with state space (SS) trajectory of the time series. Both approaches determine the system dynamics based on the Poincaré recurrence theorem as well as the trajectory divergence producing two-dimensional (2D) characteristic plots. The performance of the methods is compared with regard to their ability to distinguish between levels of valence, arousal, dominance and liking using EEG data from the "dataset for emotion analysis using physiological" database. The differences between the levels of emotional feelings were investigated based on the analysis of variance (ANOVA) test and Spearman's statistics. The results obtained from the RP features distinguish between the emotional ratings with a higher level of statistical significance as compared with those produced by the Poincaré map function. The scheme based on RPs was particularly advantageous in identifying the levels of dominance. Out of the 32 EEG electrodes examined, the RP-based approach distinguished the dominance levels in 23 electrodes, while the approach based on the Poincaré map function was only able to discriminate dominance levels in five electrodes. Furthermore, based on nonlinear analysis, significant correlations were observed over a wider area of the cortex for all affective states as compared with that reported based on the analysis of EEG power bands.

Larger Volume and Different Activation of the Brain in Response to Threat in Military Officers.

INTRODUCTION: Military missions involve stressful and life-threatening situations; however, soldiers should have a healthy cognition on the battlefield despite their high-stress levels. This is an ability that should be gained during prior military training. Successful and influential training is suggested to be associated with structural and functional improvements of the brain. METHODS: This study investigated the pattern of brain activation while observing videos relevant to life-threatening situations, in addition to brain structure. Accordingly, the obtained data were compared between 20 military members and 26 healthy controls. The study participants were all male, aged between 19 to 24 years, right-handed, studying BSc, and from the same socioeconomic status. RESULTS: The obtained data presented a larger volume in a total number of 1103 voxels of the brain (in 5 brain areas) in the military group. Furthermore, the military group suggested higher brain activation in the visual processing areas of the brain when observing real combat videos; however, this increment was mostly in the areas associated with motor processing and executive functions in the controls. CONCLUSION: This study indicated that military training is associated with positive structural changes in the brain. Besides, it provided a different brain activation in response to stressful situations. These findings highlighted the importance of qualified military training.

Targeted radiation energy modulation using Saba shielding reduces breast dose without degrading image quality during thoracic CT examinations.

OBJECTIVE: Breasts dose during thoracic computed tomography examinations is a serious challenge and practical dose reduction strategies is needed. The bismuth shielding is an available method for dose reduction; however, its use is on debate due to degrading effects on image quality. The aim of this study is to explore and evaluate the efficiency of a new composition of the X-ray absorbing material to achieve a shield with a lower impact on image quality. MATERIALS AND METHODS: Different shields were manufactured with combinations of various weight percentage of copper and bismuth. Dose reduction ratio and image quality were evaluated in phantom studies. A controlled trial with 20 female participants was conducted for image quality assessment. The shield with a lower impact on image quality, named Saba shielding, was used in the clinical trial. RESULTS: Shielding by one (1 T) and three thickness (3 T) of the constructed shields reduced the mean entrance skin dose of breasts about 52% and 73%, respectively. The shield with a composition of 90% Cu and 10% Bi (Saba shielding) had the lowest while the shield with 100% bismuth had the highest degrading effect on image quality. The Saba shielding could provide 21% higher dose reduction than the Bi shielding at the equivalent image quality. The 1 T Saba shielding did not cause artifacts in the reconstructed images. CONCLUSION: The Saba shielding is flexible, cheap and user-friendly for shielding breasts in thoracic CT examinations while do not have the degrading effect of the Bi shielding on image quality.

Radioprotective effect of grape seed extract against gamma irradiation in mouse bone marrow cells.

INTRODUCTION: Ionizing radiations produce free radicals which are often responsible for DNA damage or cell death. Grape seed extract (GSE) is a natural compound having an antioxidant that protects DNA, lipids, and proteins from free radical damages. In this study, radioprotective effect of the GSE has been investigated in mouse bone marrow cells using micronucleus test. MATERIALS AND METHODS: Four groups of mice were investigated in this study: Mice in Group 1 were subjected to injection of distilled water with no irradiation. Mice in Group 2 were exposed to 3 Gy gamma radiation after the injection of distillated water. Mice in Group 3 were injected with 200 mg/kg of the GSE without any irradiation. In another group, mice were exposed to three gray gamma irradiation after the injection of GSE. Animals were killed, and slides were prepared from the bone marrow cells 24 h after irradiation. The slides were stained with May Grunwald-Giemsa method and analyzed microscopically. The frequency of the micronucleated polychromatic erythrocytes (MnPCEs), micronucleated normochromatic erythrocyte (MnNCEs), and polychromatic erythrocyte/polychromatic erythrocyte + normochromatic erythrocyte (PCE/PCE + NCE) ratios was calculated. RESULTS: Injection of GSE significantly decreased the frequency of MnPCEs (P < 0.0001) and MnNCEs (P < 0.05) and increased the ratio of PCE/PCE + NCE (P < 0.0001) compared to the irradiated control group. DISCUSSION AND CONCLUSIONS: GSE could reduce clastogenic and cytotoxic effects of gamma irradiation in mice bone marrow cells; therefore, it can be concluded that the GSE is a herbal compound with radioprotective effects against gamma irradiation. Free radical scavenging and the antioxidant effects of the GSE probably are responsible mechanisms for the GSE radioprotective effects.

The Neuroprotective Effects of Long-Term Repetitive Transcranial Magnetic Stimulation on the Cortical Spreading Depression-induced Damages in Rat's Brain.

INTRODUCTION: Cortical Spreading Depression (CSD) is a propagating wave of neural and glial cell depolarization with important role in several clinical disorders. Repetitive Transcranial Magnetic Stimulation (rTMS) is a potential tool with preventive treatment effects in psychiatric and neuronal disorders. In this paper, we study the effects of rTMS on CSD by using behavioral and histological approaches in hippocampus and cortical regions. METHODS: Twenty-four rats were divided into four groups. A group of control rats were kept in their home cage during the experiment. The CSD group received four CSD inductions during 4 weeks with 1 week intervals. The CSD-rTMS group were treated with rTMS stimulation (figure-eight coils, 20 Hz, 10 min/d) for 4 weeks. The fourth group, i.e. rTMS group received rTMS stimulation similar to the CSD-rTMS group without CSD induction. RESULTS: Long-term rTMS application in treated groups significantly reduced production of dark neurons, increased the mean volume of normal neurons, and decreased the number of apoptotic neurons in cortical regions compared to the control group. The protective effects of long-term treatment by rTMS in the hippocampal regions were also studied. It was effective in some regions; however, rTMS effects on hippocampal regions were lower than cortical ones. CONCLUSION: Based on the study results, rTMS has significant preventive and protective effects in CSD-induced damages in cortical and hippocampal regions of the rat's brain.

At least eighty percent of brain grey matter is modifiable by physical activity: A review study.

The human brain is plastic, i.e. it can show structural changes in response to the altered environment. Physical activity (PA) is a lifestyle factor which has significant associations with the structural and functional aspects of the human brain, as well as with the mind and body health. Many studies have reported regional/global brain volume increments due to exercising; however, a map which shows the overall extent of the influences of PAs on brain structure is not available. In this study, we collected all the reports on brain structural alterations in association with PA in healthy humans, and next, a brain map of the extent of these effects is provided. The results of this study showed that a large network of brain areas, equal to 82% of the total grey matter volume, were associated with PA. This finding has important implications in utilizing PA as a mediator factor for educational purposes in children, rehabilitation applications in patients, improving the cognitive abilities of the human brain such as in learning or memory, and preventing age-related brain deteriorations.

A Study of Various Feature Extraction Methods on a Motor Imagery Based Brain Computer Interface System.

INTRODUCTION: Brain Computer Interface (BCI) systems based on Movement Imagination (MI) are widely used in recent decades. Separate feature extraction methods are employed in the MI data sets and classified in Virtual Reality (VR) environments for real-time applications. METHODS: This study applied wide variety of features on the recorded data using Linear Discriminant Analysis (LDA) classifier to select the best feature sets in the offline mode. The data set was recorded in 3-class tasks of the left hand, the right hand, and the foot motor imagery. RESULTS: The experimental results showed that Auto-Regressive (AR), Mean Absolute Value (MAV), and Band Power (BP) features have higher accuracy values,75% more than those for the other features. DISCUSSION: These features were selected for the designed real-time navigation. The corresponding results revealed the subject-specific nature of the MI-based BCI system; however, the Power Spectral Density (PSD) based α-BP feature had the highest averaged accuracy.

Real Time Driver's Drowsiness Detection by Processing the EEG Signals Stimulated with External Flickering Light.

The objective of this study is development of driver's sleepiness using Visually Evoked Potentials (VEP). VEP computed from EEG signals from the visual cortex. We use the Steady State VEPs (SSVEPs) that are one of the most important EEG signals used in human computer interface systems. SSVEP is a response to visual stimuli presented. We present a classification method to discriminate between closed eyes and opened eyes. Fourier transforms and power spectrum density features extracted from signals and Multilayer perceptron and radial basis function neural networks used for classification. The experimental results show an accuracy of 97% for test data.

Effects of extremely low frequency electromagnetic field (50 Hz) on pentylenetetrazol-induced seizures in mice.

The electromagnetic fields (EMF) have various behavioral and biological effects on human body. There are growing concerns about the consequences of exposure to EMF. However, some studies have shown beneficial effects of these waves on human. In this paper, we study the effect of acute, sub acute and long-term exposure to 50 Hz, 0.1 mT magnetic fields (MF) on the seizure induction threshold in mice. 64 mice are used and divided into four groups. Eight mice in any group were selected to be exposed to MF for specific duration and the others were used as a control group. The duration of the applied exposures was as follows: (1) 1 day (acute), (2) 3 days (sub acute), (3) 2 weeks (sub acute), (4) 1 month (long term). The mice were exposed 2 h for a day. After exposure, the pentylentetrazol (PTZ) is injected to the mice to induce seizure and the needed dose for the seizure induction threshold is measured. In the acute exposure, the threshold to induce seizure in the exposed and sham-exposed groups was 44.25 and 46.5 mg, respectively, while the difference was not significant (p value = 0.5). In the sub acute exposure (3 days), the mean amount of drug to induce seizure was 47.38 mg in the exposed and 43.88 mg in the sham-exposed groups, however, the difference was not significant (p value = 0.3). The results were 52.38 and 46.75 mg after 2 weeks of exposure which were not significantly different either (p value = 0.2). After 1 month of exposure to MF, the threshold for the induction of seizure was significantly increased (p value < 0.05). The mean dosage to induce seizure in the exposed and control group was 54.3 and 45.75 mg, respectively. However, considering the p value, the difference in the seizure induction threshold between the exposed and sham-exposed groups after acute and sub acute exposure was not significant, analyzing the effects of acute, sub acute and long-term exposures totally indicates that increasing the exposure time increases the seizure induction threshold.

Real-time axial motion detection and correction for single photon emission computed tomography using a linear prediction filter.

PURPOSE: We have developed an algorithm for real-time detection and complete correction of the patient motion effects during single photon emission computed tomography. The algorithm is based on a linear prediction filter (LPC). MATERIALS AND METHODS: The new prediction of projection data algorithm (PPDA) detects most motions-such as those of the head, legs, and hands-using comparison of the predicted and measured frame data. When the data acquisition for a specific frame is completed, the accuracy of the acquired data is evaluated by the PPDA. If patient motion is detected, the scanning procedure is stopped. After the patient rests in his or her true position, data acquisition is repeated only for the corrupted frame and the scanning procedure is continued. RESULTS: Various experimental data were used to validate the motion detection algorithm; on the whole, the proposed method was tested with approximately 100 test cases. The PPDA shows promising results. CONCLUSION: Using the PPDA enables us to prevent the scanner from collecting disturbed data during the scan and replaces them with motion-free data by real-time rescanning for the corrupted frames. As a result, the effects of patient motion is corrected in real time.