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1.
J Med Case Rep ; 15(1): 133, 2021 Mar 26.
Article in English | MEDLINE | ID: mdl-33766128

ABSTRACT

BACKGROUND: Neurolymphomatosis is rare. Neoplastic lymphocytes are seen to invade nerves (cranial or peripheral), nerve roots or other related structures in patients with hematological malignancy. It is a separate entity from central nervous system lymphoma. Neurolymphomatosis has most commonly been described in association with B-cell non-Hodgkin lymphoma. Neurolymphomatosis in the context of Burkitt lymphoma and the post-renal transplant setting has not been described before. CASE REPORTS: We report for the first time in the Arabian Gulf countries and nearby Arab states four cases of neurolymphomatosis (one Asian, and the other 3 are from Arabic nationals) occurring between 2012 and 2017 involving the median nerve, optic nerve, nerve root and cauda equina in patients with Burkitt lymphoma, Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and diffuse large B-cell lymphoma. CONCLUSIONS: Neurolymphomatosis is rare and can be difficult to diagnose by biopsy but reliably confirmed by a combined imaging approach. Prior treatment with high-dose dexamethasone might suppress 18F-fluorodeoxyglucose (FDG) activity and decrease the sensitivity of positron emission tomography/computed tomography (PET/CT). The prognosis is generally poor but using high-dose methotrexate as well as high-dose chemotherapy and autologous stem cell transplantation may be an effective way to treat neurolymphomatosis.


Subject(s)
Cauda Equina , Hematopoietic Stem Cell Transplantation , Neurolymphomatosis , B-Lymphocytes , Cauda Equina/diagnostic imaging , Fluorodeoxyglucose F18 , Humans , Median Nerve , Optic Nerve , Positron Emission Tomography Computed Tomography , Spinal Nerve Roots/diagnostic imaging , Transplantation, Autologous
2.
Nat Prod Res ; 24(3): 226-35, 2010 Feb.
Article in English | MEDLINE | ID: mdl-19241279

ABSTRACT

Fruit and leaf essential oils of Schinus molle showed insect repellent and insecticidal activity against Trogoderma granarium and Tribolium castaneum. In these oils, 65 components were identified by GC-MS analysis. Hydrocarbons dominated the oil composition with monoterpenes occurring in the largest amounts in fruits and leaves, 80.43 and 74.84%, respectively. p-Cymene was identified as a major component in both oils. The high yield and efficacy of S. molle essential oil against T. granarium and T. castaneum suggest that it may provide leads for active insecticidal agents.


Subject(s)
Anacardiaceae/chemistry , Coleoptera/drug effects , Fruit/chemistry , Insect Repellents/pharmacology , Plant Leaves/chemistry , Plant Oils/pharmacology , Animals , Insect Repellents/chemistry , Insecticides/chemistry , Insecticides/pharmacology , Oils, Volatile/chemistry , Oils, Volatile/pharmacology , Plant Oils/chemistry
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