ABSTRACT
A 36 year-old female with a diagnosis of systemic sclerosis suffered from an acute episode of skeletal myositis and refractory heart failure with cardiogenic shock. Despite immunosuppressive treatment with high doses of corticosteroids and hemodynamic support she died five days after admission. The autopsy showed cardiac myocytolysis, myocyte necrosis and contraction band necrosis. There are very few reported cases of severe heart failure associated to systemic sclerosis.
Subject(s)
Heart Diseases/etiology , Scleroderma, Systemic/complications , Adult , Fatal Outcome , Female , Heart Diseases/pathology , Humans , Necrosis , Scleroderma, Systemic/pathology , Shock, Cardiogenic/etiologyABSTRACT
Uma mujer de 36 años de edad con diagnóstico de esclerosis sistémica (ES) desarrolló un cuadro agudo de miositis esquelética e insuficiencia cardíaca grave. Evolucionó con shock cardiogénico y a pesar del tratamiento con drogas inotrópicas y altas dosis de corticoides falleció a los cinco días de haber ingresado. La autopsia reveló áreas de necrosis coagulativa miocárdicas con miocitolisis y necrosis en banda de contracción. Son muy pocos los casos comunicados de insuficiencia cardíaca grave asociada a la ES. (AU)
Subject(s)
Humans , Female , Adult , Scleroderma, Systemic/complications , Heart Diseases/pathology , Scleroderma, Systemic/pathology , Fatal Outcome , Shock, Cardiogenic/etiology , Heart Diseases/etiology , NecrosisABSTRACT
Uma mujer de 36 años de edad con diagnóstico de esclerosis sistémica (ES) desarrolló un cuadro agudo de miositis esquelética e insuficiencia cardíaca grave. Evolucionó con shock cardiogénico y a pesar del tratamiento con drogas inotrópicas y altas dosis de corticoides falleció a los cinco días de haber ingresado. La autopsia reveló áreas de necrosis coagulativa miocárdicas con miocitolisis y necrosis en banda de contracción. Son muy pocos los casos comunicados de insuficiencia cardíaca grave asociada a la ES.
Subject(s)
Humans , Female , Adult , Heart Diseases/pathology , Scleroderma, Systemic/complications , Fatal Outcome , Heart Diseases/etiology , Necrosis , Scleroderma, Systemic/pathology , Shock, Cardiogenic/etiologyABSTRACT
A 36 year-old female with a diagnosis of systemic sclerosis suffered from an acute episode of skeletal myositis and refractory heart failure with cardiogenic shock. Despite immunosuppressive treatment with high doses of corticosteroids and hemodynamic support she died five days after admission. The autopsy showed cardiac myocytolysis, myocyte necrosis and contraction band necrosis. There are very few reported cases of severe heart failure associated to systemic sclerosis.
