ABSTRACT
Renal sarcomas are very rare malignant tumours with a very poor prognosis. Renal leiomyosarcoma, a malignant tumour of smooth muscle origin, is the most common histological type. The article reports a case of leiomyosarcoma of renal location, with a review of the literature. A 38-year-old female patient, with no previous pathological history, consulted the nephrology department of the Teaching Hospital of Lomé for abdominal pain that had been present for 4 years. Histology showed a tumour proliferation of fasciculated architecture, made of spindle cells arranged in long bundles, with cytonuclear atypia and cytoarchitectural abnormalities. Immunohistochemical examination showed positive staining for smooth muscle actin, h-caldesmone, desmin and CD34 and negative for pancytokeratin (AE1/AE3), myogenin and PS100. Renal leiomyosarcoma is an exceptional malignancy. It remains the most common renal sarcoma, the differential diagnosis of which is based on immunohistochemical findings.
ABSTRACT
We report a case of rupture of spontaneous subcapsular splenic hematoma caused by toxic product and revealed by acute renal failure with intravascular hemolysis.
Subject(s)
Acute Kidney Injury/complications , Hematoma/diagnosis , Splenic Rupture/diagnosis , Acute Kidney Injury/physiopathology , Adult , Female , Hematoma/etiology , Humans , Rupture, Spontaneous/diagnosis , Rupture, Spontaneous/etiology , Splenic Rupture/etiologyABSTRACT
This study is a report on a case of papillary carcinoma of the kidney revealed by an abdominal contusion. The results of radiological investigations were discordant with the low intensity of the shock. The treatment consisted of radical nephrectomy because of the suspicion of a pre-existing malignancy. Histological analysis revealed a papillary carcinoma pT3N0M0. We focus on the need for performing diagnostic tests in order to avoid missing a pre-existing anomaly to the kidney trauma.
ABSTRACT
This study aims at assessing patients' quality of life during hemodialysis (HD) and determining influencing factors. This prospective study was conducted over a three-month period (December 1, 2012-February 28, 2013) at the Sylvanus Olympio University Hospital (CHU-SO) HD unit, the only center to provide such services in Togo. Respondents used the standard Medical Outcome Survey-Short Form 36 questionnaire. This study was conducted on 64 patients (44 males and 20 females = M/F ratio 2.2). Mean patient age was 45.51 ± 14.00 years old with the vast majority in the 16-44-year-old group (90.82%), and mean dialysis vintage was 2.84 ± 2.37 years (1 month to 9.5 years). The mean global quality of life score was 35.58 (standard deviation ± 15). Quality of life physical score and mental score were, respectively, 31.84 and 40.64. Physical limitation scores were 15.23, followed by general ill-health score 37.38 and poor physical function score 47.37. Mental limitation score was 30.20 and vitality score was 43.75. The quality of life was inversely proportional to patient age and the dialysis vintage, with female quality of life scores worse than male in all questionnaire parameters. Togolese dialysis patients suffer from poor quality of life. Factors underlying such poor quality of life include advanced age, female gender, long-standing history of dialysis, and patient profession.
Subject(s)
Hospitals, University , Kidney Diseases/therapy , Quality of Life , Renal Dialysis , Adolescent , Adult , Age Factors , Aged , Cross-Sectional Studies , Female , Health Status , Humans , Kidney Diseases/diagnosis , Kidney Diseases/physiopathology , Kidney Diseases/psychology , Male , Mental Health , Middle Aged , Prospective Studies , Renal Dialysis/adverse effects , Renal Dialysis/psychology , Risk Factors , Sex Factors , Surveys and Questionnaires , Time Factors , Togo , Treatment Outcome , Young AdultABSTRACT
Falls and mineral and bones disorders are both implicated in the occurrence of pathological fractures in patients undergoing chronic dialysis. However, data on falls among this population are rare. We carried out a prospective study during four weeks and included 70 patients on chronic hemodialysis with the main objectives being to evaluate the incidence of falls and factors related to it. At the end of the four weeks, 16 patients (22.86%) fell at least once, with a total of 17 falls during 4 weeks, giving an incidence of 3.2 falls per patient/year. The mean age was 40 ± 16 years. Five patients (31.2%) had a past history of pathological fractures. Ten patients (62.5%) presented intra- and post-dialysis hypotension, six (37.5%) was diagnosed of gait disorders and two (12.5%) had sensory deficit of the lower limbs. Six patients (37.5%) presented frailty. Hypotension (P=0.004), frailty (P=0.047) and sensory deficit (P=0.049) were significantly associated with the occurrence of falls. The incidence of falls is relatively high in our hemodialysis patients and real risk factors exist. Hence, it is important to implement programs for falls prevention to reduce their incidence and impact.
Subject(s)
Accidental Falls , Renal Dialysis , Adult , Aged , Aged, 80 and over , Female , Frail Elderly , Humans , Hypotension/complications , Incidence , Male , Middle Aged , Prospective Studies , Risk Factors , Sensation Disorders/complications , Young AdultSubject(s)
Anemia, Hemolytic/etiology , Blackwater Fever/diagnosis , Glucosephosphate Dehydrogenase Deficiency/complications , Malaria/complications , Parasitemia/complications , Acute Kidney Injury/blood , Acute Kidney Injury/etiology , Acute Kidney Injury/therapy , Acute Kidney Injury/urine , Adolescent , Anemia, Hemolytic/therapy , Aspirin/analogs & derivatives , Aspirin/therapeutic use , Blackwater Fever/blood , Blackwater Fever/etiology , Blackwater Fever/urine , Erythrocyte Transfusion , Glucosephosphate Dehydrogenase Deficiency/blood , Glucosephosphate Dehydrogenase Deficiency/diagnosis , Glucosephosphate Dehydrogenase Deficiency/urine , Hemoglobinuria/etiology , Hemolysis , Humans , Hyperbilirubinemia/etiology , Lysine/analogs & derivatives , Lysine/therapeutic use , Malaria/blood , Malaria/drug therapy , Male , Parasitemia/blood , Parasitemia/drug therapy , Quinine/therapeutic use , Renal Dialysis , TogoSubject(s)
Caregivers , Health Literacy , Kidney Failure, Chronic/therapy , Kidney Transplantation/statistics & numerical data , Patient Education as Topic , Renal Dialysis , Adult , Caregivers/education , Caregivers/statistics & numerical data , Female , Health Knowledge, Attitudes, Practice , Health Literacy/standards , Humans , Islam , Kidney Failure, Chronic/epidemiology , Kidney Transplantation/psychology , Male , Middle Aged , Morocco/epidemiology , Religion , Renal Dialysis/statistics & numerical data , Socioeconomic FactorsABSTRACT
OBJECTIVE: To report the first case of congenital nephrotic syndrome of the Finnish type (SNCF) in Togo associated with a new mutation of NPHS1. OBSERVATION: Our study focused on a female infant of 10months, born premature at 34weeks 6days, followed from birth to pure SNC discovered the 10th day of life. Monitoring and pregnancy outcome unremarkable. It is the third in a family of three children, the first two are killed in a similar table but not explored before 1year of age. The diagnosis is confirmed by the SNCF genetic study NPHS1 gene encoding nephrin performed in our patient and her parents showed a double mutation of which c.[106delG]+[2728T>C] and p. at the nucleotide level. [Ala36fs*6]+[Ser91OPro] at the protein level inherited from each parent. The change was made to the 10th month of death in life after sepsis in a third of cortico-resistance. CONCLUSION: The SNCF, autosomal recessive disease early, which remains a serious diagnosis, is genetic. This new mutation could she explained the severity of the SNCF in this family?