1.
Bioorg Med Chem Lett
; 19(3): 800-2, 2009 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-19109016
ABSTRACT
High throughput screening led to the discovery of a novel series of quinazolin-2-ylamino-quinazolin-4-ols as a new class of DNA polymerase III inhibitors. The inhibition of chromosomal DNA replication results in bacterial cell death. The synthesis, structure-activity relationships and functional activity are described.