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1.
Heliyon ; 10(10): e31133, 2024 May 30.
Article in English | MEDLINE | ID: mdl-38799741

ABSTRACT

The competitive advantage of the Creative Industry is an important strategy to succeed in a highly competitive global business market. The Indonesian creative industry is a strategic industry characterised by Small and Medium Enterprises (SMEs). However, these enterprises face challenges, such as low entrepreneurial orientation, low digital literation to access the global market, limited capital, lack of digital payment methods, and a focus on conventional marketing activities rather than implementing Entrepreneurial Marketing (EM). The previous research proposed that Entrepreneurial Orientation (EO) and Entrepreneurial Marketing (EM) could increase competitive advantage due to the moderating role of local wisdom culture and the government's role. Therefore, this research aims to analyse the moderating role of local wisdom culture and the government's role in the effect of EO and EM on sustainable competitive advantage development. The quantitative research design employed a self-administered survey distributed to 400 top and middle managers within the superior and priority subsectors of the creative industry. The survey targeted four provinces in Indonesia known for their high contributions to the Gross Domestic Product (GDP >9 %), based on the 'Purposive Sampling' method. The results of the SEM analysis, based on 330 useable data points, show that Local Wisdom and Government's Role significantly mediate the relationship between Sustainable Competitive Advantage and Sustainable Business Performance. The research results imply that it is necessary to empower the government's role in providing information technology infrastructure to facilitate the creative industry's access to the global marketplace and encourage the use of digital payment methods for the rapid development of sustainable competitive advantage. Theoretical contributions extend to Dynamic Capability Theory by integrating Resources Advantage Theory and Resources Base View Theory, including the moderating role of Local Wisdom and Government's Role, and examining the relationship of EO and EM with sustainable competitive advantage.

2.
Sensors (Basel) ; 24(3)2024 Jan 29.
Article in English | MEDLINE | ID: mdl-38339580

ABSTRACT

The emerging yet promising paradigm of the Internet of Vehicles (IoV) has recently gained considerable attention from researchers from academia and industry. As an indispensable constituent of the futuristic smart cities, the underlying essence of the IoV is to facilitate vehicles to exchange safety-critical information with the other vehicles in their neighborhood, vulnerable pedestrians, supporting infrastructure, and the backbone network via vehicle-to-everything communication in a bid to enhance the road safety by mitigating the unwarranted road accidents via ensuring safer navigation together with guaranteeing the intelligent traffic flows. This requires that the safety-critical messages exchanged within an IoV network and the vehicles that disseminate the same are highly reliable (i.e., trustworthy); otherwise, the entire IoV network could be jeopardized. A state-of-the-art trust-based mechanism is, therefore, highly imperative for identifying and removing malicious vehicles from an IoV network. Accordingly, in this paper, a machine learning-based trust management mechanism, MESMERIC, has been proposed that takes into account the notions of direct trust (encompassing the trust attributes of interaction success rate, similarity, familiarity, and reward and punishment), indirect trust (involving confidence of a particular trustor on the neighboring nodes of a trustee, and the direct trust between the said neighboring nodes and the trustee), and context (comprising vehicle types and operating scenarios) in order to not only ascertain the trust of vehicles in an IoV network but to segregate the trustworthy vehicles from the untrustworthy ones by means of an optimal decision boundary. A comprehensive evaluation of the envisaged trust management mechanism has been carried out which demonstrates that it outperforms other state-of-the-art trust management mechanisms.

3.
Heliyon ; 9(9): e19131, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37662809

ABSTRACT

Online-to-offline food delivery (O2OFD) services have become popular worldwide, and consumers' O2OFD usage and sedentary behavior have increased during the COVID-19 pandemic. However, whether consumers will continue to use O2OFD in the post-pandemic era is uncertain, and the relationship between sedentary lifestyle and O2OFD usage is poorly understood to date. Therefore, this study aims to investigate consumers' continued intention to use O2OFD in the post-pandemic era and their subsequent use behavior, as well as to explore the roles of sedentary lifestyle. A research model based on the unified theory of acceptance and use of technology 2 (UTAUT2), integrating network externalities and including sedentary lifestyle, was proposed. A two-stage online survey was conducted in China, with 409 eligible responses used in the data analysis. The results indicate that habit, perceived network size, and perceived complementarity were the main predictors of continued intention, whereas habit and continued intention were the primary determinants of use behavior. Sedentary lifestyle was positively related to O2OFD use behavior and moderated the effects of habit and continued intention on use behavior. In addition to its theoretical contributions, this study has implications for public policies, marketing strategies, and consumer well-being.

4.
PLoS One ; 18(7): e0288204, 2023.
Article in English | MEDLINE | ID: mdl-37440508

ABSTRACT

Young adults face many significant challenges to their financial well-being. The rising cost of living and unstable economies have impacted how they consume, manage, and save monthly income to maintain their standard of living. Hence, exploring the financial well-being of young adults in Malaysia is an intriguing and relevant research topic that deserves examination from multiple perspectives. This study aims to investigate how these three factors, namely financial knowledge and locus of control with financial behaviour as a mediator, are correlated with the financial well-being of low-income young adults in Malaysia. A total of 520 young adults from North, Central, South, East zones in Peninsular Malaysia and East Malaysia were randomly chosen using a multi-stage sampling technique as the sample of this study. Data in this study were obtained using a set of questionnaire-based survey through cross-sectional study and then scrutinized using IBM SPSS (Statistical Package of Social Science). This study discovered that financial knowledge, internal and external locus of control, and financial behaviour were significantly correlated with the financial well-being of low-income young adults. The findings also demonstrate that financial behaviour mediates the correlation between financial knowledge, both internal and external locus of control, and financial well-being. This study is one of the very few important studies that explore the link between financial literacy, locus of control, financial behaviour, and financial well-being among low-income young adults. This study also found an interesting and noteworthy fact regarding the impact of the minimum monthly wage policy on highly educated young adults in Malaysia, which is worth discussing and needs to be alerted to the policymakers and leaders of the country. Therefore, the findings of this study can be utilized as a starting point by policymakers, government organizations, and non-governmental organizations to create new initiatives aimed at raising financial well-being among the younger generation.


Subject(s)
Internal-External Control , Poverty , Young Adult , Humans , Malaysia , Cross-Sectional Studies , Income
5.
Article in English | MEDLINE | ID: mdl-36429983

ABSTRACT

The food delivery service is the most typical and visible example of online-to-offline (O2O) commerce. More consumers are using food delivery services for various reasons during the COVID-19 pandemic, making this business model viral worldwide. In the post-pandemic era, offering food delivery services will become the new normal for restaurants. Although a growing number of publications have focused on consumer behavior in this issue, no review paper has addressed current research and industry trends. Thus, this paper aims to review the literature published from 2020 to the present (October 2022) on consumers' use of food delivery services during the pandemic. A thematic review was conducted, with 40 articles searched from Scopus and Web of Science being included. Quantitative findings showed current research trends, and thematic analyses formed eight themes of factors influencing consumer behavior: (1) technical and utilitarian factors, (2) system-related attributes, (3) emotional and hedonic factors, (4) individual characteristics, (5) service quality, (6) risk-related factors, (7) social factors, and (8) food-related attributes. The paper also emphasizes COVID-19-related influences and suggests promising future research directions. The results offer insights into industry practices and starting points for future research.


Subject(s)
COVID-19 , Food Services , Humans , Pandemics , COVID-19/epidemiology , Problem Solving , Consumer Behavior
6.
Article in English | MEDLINE | ID: mdl-36231802

ABSTRACT

This paper aims to analyse factors affecting financial stress among the Bottom 40 Percent (B40) group of Malaysian households, reflecting overall financial well-being. Data were collected through questionnaires from 1008 respondents across five major regions in Malaysia. The data were analysed using Exploratory Factor Analysis (EFA) and Partial Least Squares-Structural Equation Modelling (PLS-SEM). This study provides evidence that financial behaviour, financial vulnerability (debt and income), and locus of control (luck and self-confidence) significantly affect financial stress among B40 households. The results show a significantly positive relationship between financial stress with financial vulnerability (debt and income) and locus of control (self-confidence). On the contrary, financial behaviour and locus of control (luck) show a significant negative relationship with financial stress. The result also indicates that financial stress affects financial well-being. Overall, the findings indicate that policy-makers should invent more effective and substantial stimulus packages or other measures to reduce the financial burden on B40 households. The findings could eventually provide insights for future research to delve into the social impact of financial stress. This study also has established a valid and reliable instrument to measure financial stress involving B40 households in Malaysia that eventually reflects the financial well-being of this group of people.


Subject(s)
Family Characteristics , Financial Stress , Humans , Income , Malaysia , Surveys and Questionnaires
7.
Article in English | MEDLINE | ID: mdl-36231818

ABSTRACT

This cross-sectional study examined the relationships of financial literacy (FL) and financial behaviour (FB) with health-related quality of life (HRQOL) during the COVID-19 pandemic among low-income working population (20-60 years old) in Malaysia. A self-administered questionnaire survey was used with HRQOL data were gathered using the EuroQol 5-Dimension 5-Level (EQ-5D-5L) tool. A generalised linear model was employed to examine the hypothesised relationships between the constructs. From 1186 respondents, the majority were employed (73.9%), had a monthly household income of less than RM 2500 (74.5%), and did not have any chronic medical conditions (74.5%). The mean (SD) values of FL, FB, and EQ-5D-5L were 5.95 (1.48), 22.08 (4.79), and 0.96 (0.10), respectively. The results of the adjusted model revealed lower age group, Malay ethnicity, Indian ethnicity, and increased FB score as significant determinants of higher EQ-5D-5L scores. With the addition of the chronic medical condition factor into the saturated model, the lower age group, ethnicity, and no chronic medical condition were significant determinants of higher HRQOL. The effects of FB on QOL were confounded by chronic diseases, implying that interventions that focus on improving FB for those with chronic medical condition may help to improve the QOL among the low-income working population.


Subject(s)
COVID-19 , Quality of Life , Adult , COVID-19/epidemiology , Chronic Disease , Cross-Sectional Studies , Health Status , Humans , Literacy , Malaysia/epidemiology , Middle Aged , Pandemics , Surveys and Questionnaires , Young Adult
8.
Work ; 73(4): 1245-1253, 2022.
Article in English | MEDLINE | ID: mdl-36093653

ABSTRACT

BACKGROUND: Hand injuries affect a person's functioning, thus impeding their abilities to return to work. There is a limited understanding in return to work of the overall predictors when including hand characteristics and functional abilities. Therefore, it is essential to identify the most relevant predictors in return to work among individuals with a hand injury. OBJECTIVES: (1) To compare hand function characteristics and functional abilities of injured workers who have or have not returned to work. (2) To estimate hand function characteristics and functional abilities as predictors to return to work. METHODS: One hundred and fifteen adult workers with hand injuries aged 18- 59 years old from five general hospitals in Malaysia participated in a cross-sectional study. Predictors were estimated using logistic regression. RESULTS: There was a significant association between occupational sector (p = 0.012), injury duration (p = 0.024), occupational performance (p = 0.009) and satisfaction with performance (p < 0.001), grip strength of injured hand (p = 0.045- 0.002) and the Disability of Arm, Shoulder and Hand (DASH) disability/symptom (p = 0.001) with the person's return to work status. Significant predictors of return to work were identified using the Canadian Occupational Performance Measure (COPM) satisfaction's score, DASH disability/symptoms' score and duration of the injury. CONCLUSION: As two main predictors of return to work were COPM satisfaction and DASH disability/symptoms, occupational therapists working in rehabilitation should focus on achieving functional performance and satisfaction within the optimal time.


Subject(s)
Hand Injuries , Occupational Injuries , Adult , Humans , Adolescent , Young Adult , Middle Aged , Return to Work , Cross-Sectional Studies , Canada , Hand Injuries/rehabilitation , Upper Extremity , Occupational Injuries/complications , Occupational Injuries/rehabilitation , Disability Evaluation
9.
Front Psychol ; 13: 858630, 2022.
Article in English | MEDLINE | ID: mdl-35664172

ABSTRACT

The main objective of this study is to investigate the associations between financial knowledge, locus of control (LOC) and perceived financial wellbeing (FWB) with financial behaviour as a mediator among young adults from low-income households in Malaysia, controlling for education and income. The sample of this study consisted of 482 young adults from five different zones in Peninsular and East Malaysia, which were selected using a multi-stage sampling technique. Data were collected using a set of questionnaire-based surveys. The data were then analysed using Covariance Based Structural Equation Modelling (SEM). The study found that financial knowledge and external LOC as well as financial behaviour were significantly correlated with the perceived FWB of low-income young adults in Malaysia. The results also revealed that financial behaviour mediates the influence by financial knowledge and internal LOC on perceived FWB controlling for education and income. The findings of this study provide insights into the factors of perceived FWB of low-income young adults in Peninsular and East Malaysia. Policymakers, government and non-government organisations may utilise this study to develop new policies, financial programmes or campaigns to enhance the FWB of low-income young adults in Malaysia.

10.
Molecules ; 27(12)2022 Jun 16.
Article in English | MEDLINE | ID: mdl-35744987

ABSTRACT

Paramyosins, muscle proteins occurring exclusively in invertebrates, are abundant in seafoods. The potential of seafood paramyosins (SP) as sources of anti-angiotensin-converting-enzyme (ACE) and anti-dipeptidyl-peptidase (DPP-IV) peptides is underexplored. This in silico study investigated the release of anti-ACE and anti-DPP-IV peptides from SP after gastrointestinal (GI) digestion. We focused on SP of the common octopus, Humboldt squid, Japanese abalone, Japanese scallop, Mediterranean mussel, Pacific oyster, sea cucumber, and Whiteleg shrimp. SP protein sequences were digested on BIOPEP-UWM, followed by identification of known anti-ACE and anti-DPP-IV peptides liberated. Upon screening for high-GI-absorption, non-allergenicity, and non-toxicity, shortlisted peptides were analyzed via molecular docking and dynamic to elucidate mechanisms of interactions with ACE and DPP-IV. Potential novel anti-ACE and anti-DPP-IV peptides were predicted by SwissTargetPrediction. Physicochemical and pharmacokinetics of peptides were predicted with SwissADME. GI digestion liberated 2853 fragments from SP. This comprised 26 known anti-ACE and 53 anti-DPP-IV peptides exhibiting high-GI-absorption, non-allergenicity, and non-toxicity. SwissTargetPrediction predicted three putative anti-ACE (GIL, DL, AK) and one putative anti-DPP-IV (IAL) peptides. Molecular docking found most of the anti-ACE peptides may be non-competitive inhibitors, whereas all anti-DPP-IV peptides likely competitive inhibitors. Twenty-five nanoseconds molecular dynamics simulation suggests the stability of these screened peptides, including the three predicted anti-ACE and one predicted anti-DPP-IV peptides. Seven dipeptides resembling approved oral-bioavailable peptide drugs in physicochemical and pharmacokinetic properties were revealed: AY, CF, EF, TF, TY, VF, and VY. In conclusion, our study presented in silico evidence for SP being a promising source of bioavailable and safe anti-ACE and anti-DPP-IV peptides following GI digestions.


Subject(s)
Dipeptidyl-Peptidase IV Inhibitors , Tropomyosin , Angiotensin-Converting Enzyme Inhibitors/chemistry , Cheminformatics , Digestion , Dipeptidyl Peptidase 4/chemistry , Dipeptidyl-Peptidase IV Inhibitors/chemistry , Dipeptidyl-Peptidases and Tripeptidyl-Peptidases , Molecular Docking Simulation , Peptides/chemistry , Seafood
11.
Article in English | MEDLINE | ID: mdl-35564930

ABSTRACT

The interrelation between food security, academic performance, and psychosocial factors remains unclear. This study aims to identify psychosocial factors as mediators of food security status and academic performance among university students at one of Malaysia's public universities. Respondents included 663 bachelor's degree students from seven randomly selected programmes at the university. Data on demographic and socioeconomic characteristics, food security status (US Adult Food Security Survey Module, FSSM), psychosocial factors (DASS-21), and academic performance were collected using an online survey. The SPSS PROCESS macro was used to perform mediation analysis. The result (ß = −0.0182, p < 0.001) indicates that food insecurity is associated with poor academic performance. As well as that, an increase in anxiety (ß = −0.0027, p < 0.05) and depression (ß = −0.0025, p < 0.05) was significant associated with a decrease in academic performance. Furthermore, anxiety and depression serve as significant mediators in the relationship between food security and academic performance. Alleviating food insecurity is not only a way to improve academic performance; it can also improve academic performance by reducing anxiety and depression.


Subject(s)
Academic Performance , Food Supply , Adult , Cross-Sectional Studies , Food Security , Humans , Socioeconomic Factors , Students , Universities
12.
New Phytol ; 234(5): 1664-1677, 2022 06.
Article in English | MEDLINE | ID: mdl-35201608

ABSTRACT

Tree size shapes forest carbon dynamics and determines how trees interact with their environment, including a changing climate. Here, we conduct the first global analysis of among-site differences in how aboveground biomass stocks and fluxes are distributed with tree size. We analyzed repeat tree censuses from 25 large-scale (4-52 ha) forest plots spanning a broad climatic range over five continents to characterize how aboveground biomass, woody productivity, and woody mortality vary with tree diameter. We examined how the median, dispersion, and skewness of these size-related distributions vary with mean annual temperature and precipitation. In warmer forests, aboveground biomass, woody productivity, and woody mortality were more broadly distributed with respect to tree size. In warmer and wetter forests, aboveground biomass and woody productivity were more right skewed, with a long tail towards large trees. Small trees (1-10 cm diameter) contributed more to productivity and mortality than to biomass, highlighting the importance of including these trees in analyses of forest dynamics. Our findings provide an improved characterization of climate-driven forest differences in the size structure of aboveground biomass and dynamics of that biomass, as well as refined benchmarks for capturing climate influences in vegetation demographic models.


Subject(s)
Carbon , Tropical Climate , Biomass , Temperature , Wood
13.
Cad. Bras. Ter. Ocup ; 30: 2890, 2022. tab
Article in English | LILACS-Express | LILACS, Index Psychology - journals | ID: biblio-1384231

ABSTRACT

Abstract Introduction Occupation-based intervention (OBI) is defined as an intervention using a clients' occupation and purposeful activities as a treatment medium to achieve the client's goals. Several barriers to practising OBI have been reported in previous studies. However, limited research has been done to identify these perceived barriers to applying OBI in Malaysia's various occupational therapy practice areas. Objective This study aimed to identify perceived barriers to applying OBI in Malaysia's three main occupational therapy practice areas including physical, psychiatry and paediatric. Method A cross-sectional study design was employed, and participants were recruited using a purposive sampling strategy. Data was collected using an online survey from a Delphi study. Results Two hundred ninety-eight Malaysian occupational therapists aged between 22 and 56 years old participated in this study. The study identified several perceived barriers from the client factors, the contextual factors, occupation as treatment modalities and logistical issues. A statistically significant difference was found in the perceived barriers of applying OBI between different areas of occupational therapy practice (p=.013), working experience (p=.003), and position of occupational therapists (p=.001). Conclusion This study suggests that perceived barriers to applying OBI were influenced by the area of practice, working experience and position of the occupational therapists. The results highlight the need to identify potential solutions to applying OBI through research and education.


Resumo Introdução Intervenção baseada na ocupação (OBI) é definida como uma intervenção usando a ocupação dos sujeitos e as atividades propostas como meio de tratamento, para atingir os objetivos dos sujeitos. Várias barreiras com relação à prática de OBI foram relatadas em estudos anteriores. No entanto, pesquisas limitadas foram feitas para identificar essas barreiras percebidas para a aplicação do OBI nas várias áreas de prática de terapia ocupacional na Malásia. Objetivo Este estudo teve como objetivo identificar as barreiras percebidas para a aplicação do OBI nas três principais áreas de prática de terapia ocupacional na Malásia, incluindo áreas físicas, psiquiátricas e pediátricas. Método Um desenho de estudo transversal foi empregado e os participantes foram recrutados usando uma estratégia de amostragem intencional. Os dados foram coletados por meio de uma pesquisa online de um estudo Delphi. Resultados Duzentos e noventa e oito terapeutas ocupacionais malaios com idades entre 22 e 56 anos participaram deste estudo. O estudo identificou várias barreiras percebidas nos fatores contextuais das pessoas, na ocupação como modalidades de tratamento e nas questões logística. Uma diferença estatisticamente significativa foi encontrada nas barreiras percebidas da aplicação do OBI entre diferentes áreas da prática da terapia ocupacional (p = 0,013), experiência de trabalho (p = 0,003) e posição dos terapeutas ocupacionais (p = 0,001). Conclusão Este estudo sugere que as barreiras percebidas para a aplicação do OBI foram influenciadas pela área de prática, experiência de trabalho e posição dos terapeutas ocupacionais. Os resultados destacam a necessidade de identificar soluções potenciais para a aplicação do OBI por meio de pesquisa e educação.

14.
Molecules ; 26(23)2021 Dec 06.
Article in English | MEDLINE | ID: mdl-34885982

ABSTRACT

Some seed-derived antioxidant peptides are known to regulate cellular modulators of ROS production, including those proposed to be promising targets of anticancer therapy. Nevertheless, research in this direction is relatively slow owing to the inevitable time-consuming nature of wet-lab experimentations. To help expedite such explorations, we performed structure-based virtual screening on seed-derived antioxidant peptides in the literature for anticancer potential. The ability of the peptides to interact with myeloperoxidase, xanthine oxidase, Keap1, and p47phox was examined. We generated a virtual library of 677 peptides based on a database and literature search. Screening for anticancer potential, non-toxicity, non-allergenicity, non-hemolyticity narrowed down the collection to five candidates. Molecular docking found LYSPH as the most promising in targeting myeloperoxidase, xanthine oxidase, and Keap1, whereas PSYLNTPLL was the best candidate to bind stably to key residues in p47phox. Stability of the four peptide-target complexes was supported by molecular dynamics simulation. LYSPH and PSYLNTPLL were predicted to have cell- and blood-brain barrier penetrating potential, although intolerant to gastrointestinal digestion. Computational alanine scanning found tyrosine residues in both peptides as crucial to stable binding to the targets. Overall, LYSPH and PSYLNTPLL are two potential anticancer peptides that deserve deeper exploration in future.


Subject(s)
Antineoplastic Agents/metabolism , Antioxidants/metabolism , Cheminformatics/methods , Drug Discovery/methods , Peptides/metabolism , Plant Extracts/metabolism , Seeds/chemistry , Antineoplastic Agents/chemistry , Antioxidants/chemistry , Catalytic Domain , Drug Stability , Humans , Kelch-Like ECH-Associated Protein 1/chemistry , Kelch-Like ECH-Associated Protein 1/metabolism , Molecular Docking Simulation , Molecular Dynamics Simulation , Peptides/chemistry , Peroxidase/chemistry , Peroxidase/metabolism , Plant Extracts/chemistry , Protein Binding , Xanthine Oxidase/chemistry , Xanthine Oxidase/metabolism
15.
Article in English | MEDLINE | ID: mdl-34070321

ABSTRACT

Food insecurity is a growing concern among university students. The high prevalence of food insecurity is a threat to students' health and success. Therefore, this study aims to determine an association between food security status, psychosocial factors, and academic performance among university students. A total of 663 undergraduate students in seven randomly selected faculties in Universiti Putra Malaysia participated in this study. An online survey was conducted to obtain demographic and socioeconomic characteristics, food security status (six-item USDA; food security survey module, FSSM), psychosocial factors (depression, anxiety and stress scale, DASS-21) and academic performance. Among the abovementioned participating students, 32.4% are male. About 62.8% reported to have experienced food insecurity. Binary logistic regression revealed that students whose fathers were working (AOR = 6.446, 95% CI: 1.22, 34.01) came from low- (AOR = 14.314, 95% CI: 1.565, 130.954) and middle-income groups (AOR = 15.687, 95% CI: 1.720, 143.092), and those receiving financial aid (AOR = 2.811, 95% CI: 1.602, 4.932) were associated with food insecurity. Additionally, food insecurity students were less-likely reported, with CGPA ≥ 3.7 (AOR = 0.363, 95% CI: 1.22-34.014). Food insecurity respondents had higher odds for stress (AOR = 1.562, 95% CI: 1.111, 2.192), anxiety (AOR = 3.046, 95% CI: 2.090, 4.441), and depression (AOR = 2.935, 95% CI: 2.074, 4.151). The higher institutions should identify students with food insecurity problems and future intervention programs need to be conducted to combat food insecurity among students, thus yielding benefits to their health and success.


Subject(s)
Food Insecurity , Universities , Cross-Sectional Studies , Food Supply , Humans , Malaysia/epidemiology , Male , Socioeconomic Factors , Students
16.
Health Care Women Int ; 42(4-6): 756-777, 2021.
Article in English | MEDLINE | ID: mdl-32208069

ABSTRACT

The authors' purpose of this study is to investigate the antecedents of single mothers' subjective well-being. A questionnaire-based survey was conducted using a multi-stage random sampling technique. Data were analyzed using Partial Least Square Structural Equation Modeling. The main findings are: (1) religiosity and locus of control positively influenced subjective well-being, (2) locus of control negatively influenced financial strain, (3) financial strain negatively influenced subjective well-being, and (4) age moderated the relationship between financial strain and subjective well-being. Implications and future research suggestions are discussed.


Subject(s)
Mothers , Religion , Female , Humans , Malaysia , Surveys and Questionnaires
17.
Biophys Chem ; 267: 106492, 2020 12.
Article in English | MEDLINE | ID: mdl-33035750

ABSTRACT

Aptamers are oligonucleotides and peptides around 15-100 bases in length and are suitable as detection probes or as therapeutics molecules. There are growing interests in the aptamer screening approach through computational simulation methods. DNA and RNA modelling lacks of validation on their predicted 3D structures due to less number of validation tools, unlike protein structures. We suggest an approach to design the stem-loop/hairpin for the three dimensional structure of DNA aptamers through serial applications of computational prediction methods by comparing the simulated structures with the experimental data deposited in PDB Data bank, followed by MD simulations. The result shows minimal structural differences were observed between the designed and the original NMR aptamers, and the stem-loop conformational structures were also retained during the MD thus suggesting the proposed aptamers designing methods are able to synthesize a high quality molecular structure of hairpin aptamers, comparable to the NMR structures.


Subject(s)
Aptamers, Nucleotide/chemical synthesis , Computational Chemistry , DNA/chemistry , Molecular Dynamics Simulation , Aptamers, Nucleotide/chemistry , Nuclear Magnetic Resonance, Biomolecular
18.
Adv Bioinformatics ; 2019: 6912914, 2019.
Article in English | MEDLINE | ID: mdl-31346332

ABSTRACT

Aptamer has been long studied as a substitute of antibodies for many purposes. However, due to the exceeded length of the aptamers obtained in vitro, difficulties arise in its manipulation during its molecular conjugation on the matrix surfaces. Current study focuses on computational improvement for aptamers screening of hepatitis B surface antigen (HBsAg) through optimization of the length sequences obtained from SELEX. Three original aptamers with affinity against HBsAg were truncated into five short hairpin structured aptamers and their affinity against HBsAg was thoroughly studied by molecular docking, molecular dynamics (MD) simulation, and Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) method. The result shows that truncated aptamers binding on HBsAg "a" determinant region are stabilized by the dynamic H-bond formation between the active binding residues and nucleotides. Amino acids residues with the highest hydrogen bonds hydrogen bond interactions with all five aptamers were determined as the active binding residues and further characterized. The computational prediction of complexes binding will include validations through experimental assays in future studies. Current study will improve the current in vitro aptamers by minimizing the aptamer length for its easy manipulation.

19.
Article in English | WPRIM (Western Pacific) | ID: wpr-732535

ABSTRACT

Tahfiz education has been well accepted by Muslims in Malaysia. Memorizing the Quran through rote learning can assistin improving the brain ability to process, store information and build memory. In addition, dietary intakes were reportedto contribute in the process of memorizing the Quran and to increase the levels of intelligence (IQ) among huffaz students.This cross-sectional study was conducted to measure and to determine the correlation between IQ and dietary intakeas well as between IQ and the level of trace elements among students in selected tahfiz schools and non-tahfiz school inSelangor. Questionnaires were used to obtain demographic data. Dietary intake was assessed via 3 days dietary record.Levels of trace elements in the nail samples were analyzed by using ICP-MS. Test for intelligence using WASI-II wasconducted to measure the students’ IQ. The results showed that there was a moderate positive correlation between IQ andcarbohydrate (r = 0.425, p < 0.001, a weak positive correlation between IQ and energy (r = 0.260, p < 0.05), vitaminB6 (r = 0.189, p < 0.05), vitamin B12 (r = 0.207, p < 0.05) and vitamin C (r = 0.211, p < 0.05). The levels of traceelements in nail samples showed no correlation with IQ, whereas there were moderate positive correlations between IQand dietary zinc (r = 0.375, p < 0.001) as well as between IQ and dietary iron (r = 0.303, p < 0.001). There was also amoderate positive correlation between IQ and the level of memorization (r = 0.375, p < 0.001). The results of stepwisemultiple linear regression showed that al-Quran memorization influence the level of IQ by 20 %. As a conclusion, dietaryintake of certain nutrients including energy, vitamins and selected trace elements can potentially improve memorizationactivities and also IQ.

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