[Prognostic potential of sensometry in scheduled patients during the use of drugs for neuroleptanalgesia]. / Prognosticheskie vozmozhnosti sensometrii u planovykh bol'nykh pri primenenii preparatov dlia neirolepticheskoi analgezii.

Tactile and pain thresholds were determined in 116 patients 24 hours before surgery upon premedication and administration of fentanyl and droperidol during induction to anesthesia. Statistical correlation analysis has shown that high pain thresholds in patients 24 hours before surgery indicate low consumption of barbiturates during induction to anesthesia, high efficacy of drugs used for NLA, and infrequent reactions to intubation irrespective of the efficacy of premedication. Low pain thresholds after premedication predict low efficacy of drugs for NLA and high consumption of fentanyl during surgery.

[The use of liposomes for "depositing" neurotropic preparations]. / Nekotorye aspekty ispol'zovaniia liposom dlia "deponirovaniia" neirotropnykh preparatov.

The possibility of formation of some liposomal neurotropic drugs was studied by 1H-NMR method. Experiments in animals on catalepsy and epidural anaesthesia confirmed this hypothesis.

[Is fluidization of the phospholipid bilayer by general anesthetics a reason for general anesthesia?]. / Iavliaetsia li indutsirovannoe obshchimi anestetikami razzhizhenie fosfolipidnogo bisloia prichinoi obshchei anestezii?

It was found that chlorpromazine and pipolfene potentiating general anaesthesia increase viscosity of phospholipid membrane in the region of polar headgroups and in the hydrophobic area near glycerol sceleton. These results (independently of potentiating mechanism) confuse a mechanism of anaesthetics action as increased fluidity of membrane phospholipids.

[Stimulation of respiration with Piladox in experimental and clinical conditions during administration of drugs for general anesthesia]. / Stimuliatsiia dykhaniia Piladoksom v éksperimente i klinike v usloviiakh primeneniia sredstv dlia obshchei anestezii.

Experimental and clinical studies of the agent Piladox (RGH 2202) were conducted. Experiments on animals (rats, rabbits, mice) demonstrated that Piladox possesses the property of restoring respiration inhibited by narcotic analgesics and some general anesthetics as well as the respiratory-de-priming effect of acute blood loss and is a more effective stimulator of the respiratory center than cordiamine (nikethamide) or corasol. Clinical study of Piladox in 75 patients showed that intravenous infusion of 1 mg/kg of the agent in the awakening period produced a stimulating effect on respiration through increase of its frequency and increase of the respiratory volume. The minute respiratory volume in this case was even greater than the initial values, whereas the CO2 content in the blood and expired air reached the initial level. The hemodynamic values in this period remained generally stable. Piladox does not change the antinociceptive effect of the narcotic analgesics and analgesia in the immediate postoperative period when combined general anesthesia is applied.

[Prolonged peridural analgesia with morphine in the acute period of a myocardial infarct]. / Dlitel'naia peridural'naia anal'geziia morfinom v ostrom periode infarkta miokarda.

The analgetic effect of prolonged peridural analgesia with morphine was studied experimentally in rabbits. Increasing morphine dose did not noticeably enhance analgesia. Prolonged peridural analgesia with morphine was used to alleviate pain in 18 myocardial infarction patients. Morphine (2 mg) was introduced into the peridural space. The efficacy of the method is demonstrated.

[Specific and nonspecific cytolysis reactions in rheumatic patients with a low degree of activity in the process of combined treatment by a high-protein diet and drug preparations]. / Izuchenie reaktsii spetsificheskogo i nespetsificheskogo tsitoliza u bol'nykh revmatizmom s maloi stepen'iu aktivnosti v protesse kompleksnogo lecheniia vysokobelkovoi dietoi i medikamentoznymi preparatami.

Effect of therapy including high-protein diet and hormones on specific and nonspecific cytolysis was studied in patients with torpid and latent-running recurrent rheumatic carditis. The number of HeLa cells on which specific antigens (cardiac tissue extract, collagen, group C streptococcal nucleoproteid) were adsorbed significantly decreased on addition to the test target sensitized lymphocytes from the patients examined. As a result of therapy most patients showed the reduced activity of supernatants obtained from peripheral blood lymphocyte cultures that were incubated with specific antigens.

[Evaluation of the effect of a high-protein diet in combination with hormone and drug preparations on immunological homeostasis indices in rheumatism patients with a low degree of activity of the disease process]. / K otsenko vliianiia vysokobelkovoi diety v sochetanii s gormonal'no-medikamentoznymi preparatami na nekotorye pokazateli immunologicheskogo gomeostaza u bol'nykh revmatizmom s maloi stepen'iu aktivnosti protsessa.

High protein diet coupled with drugs was used for the treatment of patients with protracted and latent recurrent rheumocarditis. The mean daily doses of the drugs administered were as follows: 2 g of aspirin and 15 mg of prednisolone. With clinical improvement most patients showed a decrease in the amount of blast transformed lymphocytes in stained smears of the cultures of peripheral leukocytes incubated in the presence of cardial antigen, collagen and group C streptococcal nucleoprotein. They also manifested the diminished ability on in vitro sensitized lymphocytes to produce the leukocyte migration inhibition factor.

[T-cell activity in animals with an induced delayed allergy on a diet with a low protein content]. / Aktivnost' T-kletok u zhivotnykh s indutsirovannoi allergiei zamedlennogo tipa, nakhodiashchikhsia na ratsione s nizkim soderzhaniem belka.

The dogs fed protein deficient diet (0.7 g/kg body weight) demonstrated reduced functional activity of T lymphocytes. Particularly, this diet exerted an adverse effect on adequacy of the proliferative response of mononuclear cells in culture in vitro as well as on cytotoxicity of lymphocytes with respect to target cells.

[Parameters of polynuclear cell activity in torpid and latent recurrent rheumocarditis in the process of treatment with a high-protein diet and drug preparations]. / Nekotorye parametry aktivnosti polinuklearov u bol'nykh vialo i latentno tekushchim vozvratnym revmokarditom v protsesse lecheniia vysokobelkovoi dietoi i medikamentoznymi preparatami.

The in vitro test of direct granulation of basophils affected by specific antigens (cardial tissue, acid-soluble fraction of collagen, streptococcal allergens) was investigated in the course of treating 41 patients (29 women and 12 men aged from 20 to 50 years) suffering from a little active rheumatic fever. The patients received a complex of therapeutic measures including high-protein diet (130-140 g protein) and drugs (1.5-2.0 g acetylsalicylic acid and 15 mg of prednisolone a day). As a result of the treatment all the patients improved and demonstrated pain relief in the heart region, reduced palpitation, abatement of general weakness and fatigue. At the same time there was a decrease in the reactivity of basophilic leukocytes, shown by less number of degranulated cells in vitro, activated with specific antigens.