1.
J Theor Biol
; 582: 111748, 2024 04 07.
Article
in English
| MEDLINE
| ID: mdl-38336242
ABSTRACT
We describe a cell-based fixed-lattice model to simulate immune cell and tumor cell interaction involving MHC recognition, and FasL vs perforin lysis. We are motivated by open questions about the mechanisms behind observed kill rates of tumor cells by different types of effector cells. These mechanisms play a big role in the effectiveness of many cancer immunotherapies. The model is a stochastic cellular automaton on a hexagonal grid.