Lymphomatoid papulosis: an update and review.

Lymphomatoid papulosis (LyP) is a benign chronic often relapsing skin condition that belongs to the CD30-positive cutaneous lymphoproliferative disorders. LyP typically presents as crops of lesions with a tendency to self-resolve, and morphology can range from solitary to agminated or diffuse papules and plaques to nodules or tumours. The clinical-histological spectrum can range from borderline cases to overlap with primary cutaneous anaplastic cell lymphoma (pcALCL). Histology and immunophenotype commonly show overlap with other CD30-positive disorders and sometimes may be identical to pcALCL, making its diagnosis more difficult. Patients with LyP have an increased risk of developing a second neoplasm such as mycosis fungoides, pcALCL and/or Hodgkin lymphoma. Clinical correlation allows its proper classification and diagnosis, which is fundamental for treatment and prognosis. This review focuses on the clinical appearance, histopathological features, diagnosis, differential diagnosis and management of LyP.

Syringoid eccrine carcinoma: a clinicopathological and immunohistochemical study of four cases.

BACKGROUND: Syringoid eccrine carcinoma (SEC) is a rare malignant adnexal tumour with variable presentations. AIM: To examine the clinicopathological and immunohistochemical features of SEC. METHODS: Four cases were reviewed by three dermatopathologists and the immunohistochemical profile was examined using antibodies against CK5/6, CK7, CK14, CK20, LMWK, HMWK, EMA, mCEA, p63, ER, PR, AR, S-100 and Ber-EP4. RESULTS: The cases occurred in two men and two women, ranging in age from 61 to 87 years (mean 68.5). Two of the lesions were from the face and two from the trunk. All four lesions were composed of an atypical infiltrative mass with syringoma-like tadpole morphology with ductular differentiation and prominent desmoplasia. Three cases demonstrated perineural invasion and two had positive lymph node metastases. Immunostaining was variable. Immunohistochemistry positivity was as follows: three out of four cases were positive for CK5/6, CK7 (2/4), CK14 (1/3), CK20 (0/2), HMWK (0/2), LMWK (1/2), EMA (3/4), mCEA (4/4), p63 (2/3), ER (2/3), PR (1/2), AR (0/3), S-100 (0/3) and Ber-EP4 (2/2). CONCLUSION: SEC can present on the trunk and are not limited to the head and neck region. In addition to syringoma-like tadpole structures and glandular differentiation, these tumours can also exhibit squamoid and cribriform growth patterns. Immunostaining in SEC is variable and this variability is believed to stem from this tumour's ability to differentiate along multiple routes, including sweat secretory and/or ductal differentiation.

Fiberoptic infrared radiometer for real time in situ thermometry inside an MRI system.

A warm body emits radiation whose intensity I is dependent on the surface temperature T. For T near room temperature this radiation is mostly in the mid-IR. Radiometric measurement of I is often used for non contact thermometry. Temperature measurements in situ and in remote locations can be carried out using optical fibers, but one needs fibers that are highly transparent in the mid-IR. Our group has developed fibers made of silver halides. These are flexible, nontoxic, not hygroscopic and highly transparent in the mid IR. These fibers served for the development of a novel fiberoptic radiometer. Using this radiometer we have measured the temperatures of samples while being imaged in an MRI system. The presence of the fibers inside the MRI system did not interfere with the operation of the MRI nor did not the MRI system affect the radiometer. The temperature measurements were made with accuracy of 0.3 degrees C, response time of 1 s and spatial resolution of 1 mm. Fiberoptic radiometers would be highly suitable for temperature measurement of human tissues, for example during surgical procedures done inside an MRI system.

Testing usability with 3D paper prototypes--Case Halton system.

In our study, we set out to see how low-fidelity three-dimensional paper prototypes could be used to test the usability of two alternative concepts for a drink can refund machine. The tests were carried out in the real environment with the actual users of the product. The tests took place before any software or hardware had been implemented. Using paper prototypes is a quantitative evaluation method which is easy to apply and suitable for product development processes with a tight schedule. We found the 3DPP modeling and testing method turned out to be useful and the results obtained had an influence on the product.

Anxiety, self-control and shooting performance.

55 rifle shooters were administered state-trait anxiety and self-control questionnaires. Shooting performance was recorded on 7 competitive occasions. Analysis indicated shooting performance is dependent more on anxiety state than on anxiety trait and self-control. Highly skilled shooters were less anxious and performed better across all competitions than moderately skilled shooters but did not differ on self-control and anxiety trait. The assumption that increased anxiety negatively affects performance through the mediation of self-control should be further studied.