ABSTRACT
We evaluated the prevalence of autoimmune thyroiditis in a random sample of 1188 schoolchildren aged 8-13 years with normalized iodine intake in the Islamic Republic of Iran. The prevalence of goitre was 39.6%; the majority had palpable but non-visible goitre. Of a subsample of 500 children, median urinary iodine excretion (18/8 microg/dL) indicated normal iodine intake. Thyroid peroxidase (TPO) antibody was positive in 3.7% of children and was significantly correlated with the prevalence of goitre and hypothyroidism. No correlation was seen between urinary iodine excretion and positive TPO antibody, mean TPO antibody, hypothyroidism or prevalence of goitre. Autoimmune thyroiditis explains some cases of goitre but other goitrogenic factors need to be evaluated.
Subject(s)
Goiter/epidemiology , Goiter/etiology , Iodine/administration & dosage , Sodium Chloride, Dietary/administration & dosage , Thyroiditis, Autoimmune/complications , Thyroiditis, Autoimmune/epidemiology , Adolescent , Age Distribution , Autoantibodies/blood , Autoantibodies/immunology , Child , Dietary Supplements/adverse effects , Energy Intake , Female , Goiter/prevention & control , Humans , Iodide Peroxidase/immunology , Iodine/adverse effects , Iodine/deficiency , Iodine/urine , Iran/epidemiology , Male , Population Surveillance , Prevalence , Risk Factors , Sex Distribution , Sodium Chloride, Dietary/adverse effects , Statistics, Nonparametric , Thyroiditis, Autoimmune/blood , Thyroiditis, Autoimmune/diagnosis , Thyroiditis, Autoimmune/immunologyABSTRACT
We evaluated the prevalence of autoimmune thyroiditis in a random sample of 1188 schoolchildren aged 8-13 years with normalized iodine intake in the Islamic Republic of Iran. The prevalence of goitre was 39.6%; the majority had palpable but non-visible goitre. Of a subsample of 500 children, median urinary iodine excretion [18/8 microg/dL] indicated normal iodine intake. Thyroid peroxidase [TPO] antibody was positive in 3.7% of children and was significantly correlated with the prevalence of goitre and hypothyroidism. No correlation was seen between urinary iodine excretion and positive TPO antibody, mean TPO antibody, hypothyroidism or prevalence of goitre. Autoimmune thyroiditis explains some cases of goitre but other goitrogenic factors need to be evaluated
Subject(s)
Prevalence , Iodine , Goiter , Hypothyroidism , Thyroiditis, Autoimmune , Thyroid Function TestsABSTRACT
The effects of menopause and renal function on serum parameters of the vitamin D-endocrine system were studied in a cross-sectional sample of 676 healthy women aged 20-74 years in Shiraz. Low serum 25-hydroxyvitamin D (25-OHD) was found in 52.9% of the women. Serum parathyroid hormone (PTH) increased significantly over the age span in premenopausal women (r= 0.13, P= 0.02). In premenopausal and postmenopausal women, serum levels of 25-OHD, phosphorus and calcium were stable across the age span. There was no significant correlation between creatinine clearance or serum PTH (r= -0.016, P= 0.66) and 25-OHD (r= 0.012, P= 0.74). The high prevalence of vitamin D deficiency warrants consideration of dietary supplementation.
Subject(s)
Kidney/physiology , Menopause/physiology , Vitamin D Deficiency/blood , Vitamin D/analogs & derivatives , Adult , Aged , Aging/physiology , Alkaline Phosphatase/blood , Calcium/blood , Creatinine/blood , Cross-Sectional Studies , Female , Health Surveys , Humans , Iran/epidemiology , Middle Aged , Parathyroid Hormone/blood , Phosphorus/blood , Postmenopause/physiology , Premenopause/physiology , Prevalence , Sampling Studies , Urban Health/statistics & numerical data , Vitamin D/blood , Vitamin D Deficiency/epidemiology , Vitamin D Deficiency/etiologyABSTRACT
The effects of menopause and renal function on serum parameters of the vitamin D-endocrine system were studied in a cross-sectional sample of 676 healthy women aged 20-74 years in Shiraz. Low serum 25-hydroxyvitamin D [25-OHD] was found in 52.9% of the women. Serum parathyroid hormone [PTH] increased significantly over the age span in premenopausal women [r= 0.13, P= 0.02]. In premenopausal and postmenopausal women, serum levels of 25-OHD, phosphorus and calcium were stable across the age span. There was no significant correlation between creatinine clearance or serum PTH [r= -0.016, P= 0.66] and 25-OHD [r= 0.012, P= 0.74]. The high prevalence of vitamin D deficiency warrants consideration of dietary supplementation
