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2.
Farmakol Toksikol ; 49(5): 90-2, 1986.
Article in Russian | MEDLINE | ID: mdl-3770183

ABSTRACT

The effect of corinfar on the blood plasma Ca2+ content and oxyhemoglobin dissociation curve was studied in 52 patients with ischemic heart disease. The drug was administered in a dose of 60 mg/day and to 5 patients in a dose of 90 mg/day for 2 weeks. A complete disappearance of angina attacks and ECG normalization were observed in 37 patients, a good effect was noted in 30 patients and no effect was seen in 13 patients. A significant decrease of Ca2+ content during treatment was noted in patients with effort angina of mild and moderate degrees. Parallelism between Ca2+ content decrease and the drug efficacy was revealed.


Subject(s)
Angina Pectoris/drug therapy , Calcium Channel Blockers/therapeutic use , Nifedipine/therapeutic use , Adult , Angina Pectoris/blood , Calcium/blood , Chronic Disease , Coronary Disease/blood , Coronary Disease/drug therapy , Drug Evaluation , Humans , Middle Aged , Oxyhemoglobins/metabolism , Physical Exertion
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