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Bioorg Med Chem Lett ; 21(15): 4512-5, 2011 Aug 01.
Article in English | MEDLINE | ID: mdl-21723121

ABSTRACT

The synthesis (Pd-mediated coupling strategy) and characterization (NMR, IR, elemental analysis, etc.) of a short series of quinoline-oxazole hybrid compounds has been carried out. These materials are found to be moderately active against Plasmodium falciparum in vitro, with activities in the sub-micromolar range, and to display acceptable cytotoxicity to mononuclear leukocytes. Chemical modification strategies, with the intention to increase the biological potency of this new class of anti-malarial agents, are discussed.


Subject(s)
Antimalarials/chemical synthesis , Chloroquine/chemistry , Plasmodium falciparum/drug effects , Antimalarials/chemistry , Antimalarials/pharmacology , Chloroquine/chemical synthesis , Chloroquine/pharmacology , Models, Biological , Oxazoles/chemistry , Quinolines/chemistry
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