ABSTRACT
Solutions containing 0.2% of a bis-biguanide, chlorhexidine (positive control), and four bis-amidinourea antimicrobial agents were tested in beagle dogs in a 12-week study. The five agents significantly reduced clinical plaque and gingivitis scores, and gingival fluid volumes in treated dogs, compared with water. All compounds reduced the stain area scores compared to water controls. Stain intensity scores were higher for chlorhexidine than for the four new antimicrobial agents and the water controls. There were no overt behavioral changes. Histological examination of oral tissues revealed no irritation.
Subject(s)
Chlorhexidine/pharmacology , Dental Plaque/prevention & control , Gingivitis/prevention & control , Tooth Discoloration/physiopathology , Urea/analogs & derivatives , Adamantane/analogs & derivatives , Adamantane/pharmacology , Animals , Disinfectants/pharmacology , Dogs , Female , Gingival Crevicular Fluid/drug effects , Guanidine/analogs & derivatives , Guanidines/pharmacology , Male , Piperazines/pharmacology , Urea/pharmacologyABSTRACT
The effect of toothbrushes on soft tissue abrasion was measured using hamster cheek pouch tissue brushed mechanically for various intervals. The detection of protein removed during brushing was used as an index of tissue abrasion. The method was found to be sensitive in detecting the effects of brush load, number of strokes applied, and the texture of the brush. The results further showed that the mechanical removal of sharp edges from bristle tips substantially reduced the level of soft tissue abrasion while a dentifrice polishing agent applied to the tissue with a brush did not increase the abrasive effect of the brush.
