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Bioorg Med Chem Lett
; 24(5): 1417-20, 2014 Mar 01.
Article
in English
| MEDLINE
| ID: mdl-24485781
ABSTRACT
A series of methoxynaphthalene amides were prepared and evaluated as alternatives to quinolizidinone amide M1 positive allosteric modulators. A methoxy group was optimal for M1 activity and addressed key P-gp issues present in the aforementioned quinolizidinone amide series.