Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Noro Psikiyatr Ars ; 56(2): 92-98, 2019 Jun.
Article in English | MEDLINE | ID: mdl-31223239

ABSTRACT

INTRODUCTION: Chronic pain is associated with maladaptive plastic changes in the brain. It is usually more prominent in acquired pathologies of nerve fibers as in diabetic neuropathy despite less severe degeneration than hereditary neuropathies. Based on clinical differences concerning pain perception, we hypothesized that functional connectivity analysis would reveal distinct patterns in resting-state networks in these groups. METHODS: Ten diabetic patients with painful neuropathy (5F/5M; mean age=50.10±6.05 years), 10 patients with hereditary neuropathy (5F/5M; mean age=37.80±14.01 years), 18 age-and gender-matched healthy controls (eight for painful diabetic neuropathy and 10 for hereditary neuropathy) and seven diabetic controls without painful neuropathy were enrolled in the study. All subjects (n=45) underwent a 5-min resting-state scan in a 3T magnetic resonance scanner. The images were analyzed with seed-based functional connectivity method. The group-level maps of the default mode network and insula-cingulate network were identified for each group. RESULTS: Patients with hereditary neuropathy displayed increased connectivity between left insula and left anterior cingulate cortex and inversely correlated activity between left insula and left inferior parietal lobule compared to their controls. In patients with painful diabetic neuropathy, the major findings were the increased connectivity between left anterior cingulate cortex and posterior cingulate cortex/precuneus, and the increased connectivity between medial prefrontal cortex and left medial temporal region compared to their controls. CONCLUSION: This study revealed that hereditary and diabetic painful neuropathy patients exhibit different patterns of functional connectivity. The clinical differences in these groups regarding the presence of neuropathic pain may relate to this difference in cortical organization.

2.
Cogn Behav Neurol ; 27(3): 155-9, 2014 Sep.
Article in English | MEDLINE | ID: mdl-25237746

ABSTRACT

A progressive encephalopathy of unknown etiology has been described in patients with primary immunodeficiency disorders. In this report, we characterize the clinical features of this progressive neurodegenerative dementing disorder in a young man with Bruton agammaglobulinemia, through neuropsychological tests and a video sequence. The clinical course of the encephalopathy seems rather uniform: Cognition, especially frontal lobe function, is affected in the early stages, and some patients develop movement disorders. The syndrome causes severe cognitive and physical disability, and can eventually be fatal. The autoimmunity results from dysregulated immune responses, but the underlying mechanism has not yet been fully explained.


Subject(s)
Agammaglobulinemia/complications , Agammaglobulinemia/diagnosis , Brain/pathology , Cognition Disorders/etiology , Genetic Diseases, X-Linked/complications , Genetic Diseases, X-Linked/diagnosis , Immunoglobulins, Intravenous/administration & dosage , Movement Disorders/etiology , Agammaglobulinemia/drug therapy , Agammaglobulinemia/pathology , Agammaglobulinemia/physiopathology , Agammaglobulinemia/psychology , Atrophy , Child, Preschool , Cognition Disorders/genetics , Cognition Disorders/immunology , Diagnosis, Differential , Disease Progression , Frontal Lobe/pathology , Genetic Diseases, X-Linked/drug therapy , Genetic Diseases, X-Linked/pathology , Genetic Diseases, X-Linked/physiopathology , Genetic Diseases, X-Linked/psychology , Humans , Immunoglobulins, Intravenous/adverse effects , Magnetic Resonance Imaging , Male , Movement Disorders/genetics , Movement Disorders/immunology , Neurodegenerative Diseases/etiology , Neuropsychological Tests , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...