Investigation of Components in Roasted Green Tea That Inhibit Streptococcus mutans Biofilm Formation.

Streptococcus mutans form oral biofilms (BFs) and cause dental caries. Roasted green tea (RGT) is prepared by roasting the tea plant, and RGT-specific polyphenols are produced during the roasting process. Catechins, polyphenols in green tea, have BF inhibitory activity against S. mutans; therefore, RGT-specific polyphenols are also expected to have this activity. However, there are few reports on the structural and functional properties of RGT. This study aimed to investigate the inhibitory activity of RGT against S. mutans BF formation and to investigate the active compounds. RGT extract fractionation and BF inhibitory assay were performed. Strong activity was confirmed in the RGT fractions that had medium-high hydrophobicity, were rich in phenolic hydroxyl groups, and lacked catechins. A peak comprising compounds with molecular weights of 918 (mw918) and 1050 (mw1050) was purified from the fraction. Since BF inhibitory activity was confirmed for this peak, these compounds were considered to be part of the active ingredients. The mw918 polyphenol was detected only in RGT and it was thought to be produced during the roasting process. The results of this research will serve as a basis for the future application of RGT as a safe and effective anti-caries agent.

Evaluation of Electric Muscle Stimulation Method for Haptic Augmented Reality.

Currently, visual Augmented Reality (AR) technology is widespread among the public. Similarly, haptic AR technology is also widely practiced in the academic field. However, conventional haptic AR devices are not suitable for interacting with real objects. These devices are often held by the users, and they contact the real object via the devices. Thus, they prevent direct contact between the user and real objects. To solve this problem, we proposed employing Electrical Muscle Stimulation (EMS) technology. EMS technology does not interfere with the interaction between the user and the real object, and the user can wear the device. First, we examined proper stimulus waveforms for EMS, in addition to pulse waveforms. At the same time, we examined the appropriate frequency and pulse width. The waveforms that we used this time were a sawtooth wave, a reverse sawtooth wave, and a sine wave. Second, to clarify the characteristic of the force presented by the EMS, we measured the relationship between the input voltage and the force presented and obtained the point of subjective equality using the constant method. Subsequently, we presented the bump sensation using EMS to the participants and verified its effectiveness by comparing it with the existing methods.

Spatiotemporal Thermal Control Effects on Thermal Grill Illusion.

The thermal grill illusion induces a pain sensation under a spatial display of warmth and coolness of approximately 40 °C; and 20 °C. To realize virtual pain display more universally during the virtual reality experience, we proposed a spatiotemporal control method to realize a variable thermal grill illusion and evaluated the effect of the method. First, we examined whether there was a change in the period until pain occurred due to the spatial temperature distribution of pre-warming and pre-cooling and verified whether the period until pain occurred became shorter as the temperature difference between pre-warming and pre-cooling increased. Next, we examined the effect of the number of grids on the illusion and verified the following facts. In terms of the pain area, the larger the thermal area, the larger the pain area. In terms of the magnitude of the pain, the larger the thermal area, the greater the magnitude of the sensation of pain.

Sensing and Rendering Method of 2-Dimensional Haptic Texture.

Nowadays, touchscreens have been used worldwide. However, most of them lack realistic haptic feedback. Several haptic feedback devices employ one-dimensional vibration only. We aim at a novel rendering method for direction-controlled 2-dimensional vibration display to present texture information. This paper proposed a rendering method of texture information that enables lateral-force-based 2-dimensional vibration in the X and Y-axis. Moreover, we proposed combining AKAZE image feature information of the textures to improve the fidelity for larger periodic textures. We held experiments to evaluate the fidelity of the proposed method. The result shows that the proposed method has higher fidelity in presenting randomized textures and large periodic textures than the conventional method.

Copper-Catalyzed Oxidative Benzylic C(sp3 )-H Cyclization for the Synthesis of ß-Lactams.

ß-Lactams are important structural motifs because of their ubiquity in natural products and pharmaceuticals. We report herein a Cu-catalyzed intramolecular oxidative C(sp3 )-H amidation for the synthesis of ß-lactams using tBuOOtBu. This method is based on Kharasch-Sosnovsky amidation and does not require prefunctionalization of C(sp3 )-H bonds or the installation of a directing group, thereby allowing for the straightforward synthesis of ß-lactams. Our intramolecular functionalization protocol can be extended to diverse benzylic C(sp3 )-H bonds and shows excellent functional-group tolerance.

Precise shape reconstruction by active pattern in total-internal-reflection-based tactile sensor.

We are developing a total-internal-reflection-based tactile sensor in which the shape is reconstructed using an optical reflection. This sensor consists of silicone rubber, an image pattern, and a camera. It reconstructs the shape of the sensor surface from an image of a pattern reflected at the inner sensor surface by total internal reflection. In this study, we propose precise real-time reconstruction by employing an optimization method. Furthermore, we propose to use active patterns. Deformation of the reflection image causes reconstruction errors. By controlling the image pattern, the sensor reconstructs the surface deformation more precisely. We implement the proposed optimization and active-pattern-based reconstruction methods in a reflection-based tactile sensor, and perform reconstruction experiments using the system. A precise deformation experiment confirms the linearity and precision of the reconstruction.