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1.
Int J Clin Pract ; 75(4): e13735, 2021 Apr.
Article in English | MEDLINE | ID: mdl-32996259

ABSTRACT

OBJECTIVE: To present a nation-wide analysis of the workload of urology departments in Turkey week-by-week during Covid-19 pandemic. METHODOLOGY: The centres participating in the study were divided into three groups as tertiary referral centres, state hospitals and private practice hospitals. The number of outpatients, inpatients, daily interventions and urological surgeries were recorded prospectively between 9-March-2020 and 31-May-2020. All these variables were recorded for the same time interval of 2019 as well. The weekly change of the workload of urology during pandemic period was evaluated, also the workload of urology and the distributions of certain urological surgeries were compared between the pandemic period and the same time interval of the year 2019. RESULTS: A total of 51 centres participated in the study. The number of outpatients, inpatients, urological surgeries and daily interventions were found to be dramatically decreased by the 3rd week of pandemics in state hospitals and tertiary referral centres; however, the daily urological practice were similar in private practice hospitals throughout the pandemic period. When the workload of urology in pandemic period and the same time interval of the year 2019 were compared, a huge decrease was observed in all variables during pandemic period. However, temporary measures like ureteral stenting, nephrostomy placement and percutaneous cystostomy have been found to increase during Covid-19 pandemic compared with normal life. CONCLUSIONS: Covid-19 pandemic significantly affected the routine daily urological practice likewise other subspecialties and priority was given to emergent and non-deferrable surgeries by urologists in concordance with published clinical guidelines.


Subject(s)
COVID-19 , Urology , Humans , Pandemics , SARS-CoV-2 , Turkey/epidemiology
3.
J Laparoendosc Adv Surg Tech A ; 30(12): 1301-1307, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32397802

ABSTRACT

Purpose: To compare the effects of retrograde intrarenal surgery (RIRS) and percutaneous nephrolithotomy (PNL) on postoperative pain and their differences in terms of the postoperative need for analgesics in the treatment of 2-4 cm kidney stones. Methods: A total of 132 patients who suffered from renal stones 2-4 cm in size and had surgery at our urology clinic between April 2015 and April 2017 were enrolled in this prospective study (NCT02430168). Patients were randomized into either the RIRS group (Group 1) or PNL group (Group 2) in a ratio of 1:1. Postoperative visual analog scale (VAS) values at 8 and 24 hours postoperatively and analgesic treatments of patients were recorded. Results: Patients from both groups had similar demographic characteristics. Stone-free states were achieved in 37 (74%) patients in the RIRS group and 45 (90%) patients in the PNL group. Postoperative complication rates were similar in two groups. Moreover, there was no statistically significant difference between the groups in terms of the postoperative need for analgesics (P = .309). However, the PNL group had higher VAS values (P < .001). Conclusion: Although the early postoperative pain scales were high in the PNL group, there was no significant difference between the groups in terms of the standard analgesic treatments for achieving patient's comfort. PNL, which has similar complications, but with higher success rates, compared with RIRS, did not require additional analgesic treatment during postoperative pain management. Thus, in our opinion, PNL should still remain as a first choice in treatment of 2-4 cm renal stones.


Subject(s)
Analgesics/therapeutic use , Kidney Calculi/surgery , Nephrolithotomy, Percutaneous/methods , Pain, Postoperative/prevention & control , Female , Humans , Kidney Calculi/diagnosis , Male , Middle Aged , Pain Measurement , Pain, Postoperative/diagnosis , Prospective Studies , Retrospective Studies , Tomography, X-Ray Computed , Treatment Outcome
4.
Int Braz J Urol ; 46(3): 341-350, 2020.
Article in English | MEDLINE | ID: mdl-32167695

ABSTRACT

PURPOSE: This study aims to evaluate the oncological and functional results of open partial nephrectomy (OPN) and laparoscopic partial nephrectomy (LPN) at the T1b clinical stage, which constitutes 25% of renal cell carcinomas (RCC) at diagnosis. MATERIALS AND METHODS: The characteristics of 63 patients with stage T1b solitary tumor who underwent OPN (41) or LPN (22) were compared. The survival analysis was performed using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were performed to determine the factors affecting disease-free survival. Potential predictive factors, which might affect the postoperative glomerular filtration rate (GFR), were evaluated using multivariate linear regression analysis. RESULTS: No differences were observed between OPN and LPN groups regarding patient and tumor characteristics. Although the warm ischemia time, intraoperative estimated blood loss, and operation duration were higher in the LPN group, no differences were noted between the two techniques regarding complication rates (p<0.001, p=0.023, p≤0.001, and p=0.190, respectively). The median hospitalization time was shorter in the LPN group than that in the OPN group (4 and 5 days, respectively), with less severe complications. No intergroup differences were observed regarding cancer-specific survival (CSS), disease-free survival (DFS), and overall survival (OS). The evaluation of the factors affecting DFS showed that age was an effective parameter (RR = 1.112, 95% CI: 1.010-8.254), but the surgical technique was not. CONCLUSION: No differences were observed between OPN and LPN techniques between oncological and functional outcomes in patients with clinical stage T1b RCC.


Subject(s)
Carcinoma, Renal Cell , Kidney Neoplasms , Laparoscopy , Female , Humans , Male , Nephrectomy , Retrospective Studies , Treatment Outcome
5.
Urol J ; 14(1): 2949-2954, 2017 Jan 18.
Article in English | MEDLINE | ID: mdl-28116738

ABSTRACT

PURPOSE: In this retrospective study, we aimed to compare the outcomes in patients who have been treated withpercutaneous nephrolithotomy (PNL) and retrograde intrarenal surgery (RIRS) on renal stones ≥ 2 cm size. MATERIALS AND METHODS: We evaluated patients who underwent PNL or RIRS for renal stones ≥ 2 cm size betweenNovember 2011 and November 2014. Stone size, operation, fluoroscopy and hospitalization time, success rates,stone-free rates and complication rates were compared in both groups. Patients were followed for three months. RESULTS: 254 patients were in the PNL Group. 185 patients were in the RIRS Group. The mean age was 46.88 and48.04 years in PNL and RIRS groups, respectively.The patient and stone characteristics (age, gender, Body Mass Index, kidney anomaly, SWL history and stoneradioopacity) were similar between two groups.The mean stone size preoperatively was significantly larger in patients who were treated with PNL (26.33mm.vs24.04mm.; P = .006). In the RIRS group, the mean stone number was significantly higher than PNL group (P <.001).The mean operative, fluoroscopy and hospitalization time were significantly higher in PNL group (P < .001). Thestone-free rate was 93.3% for the PNL group and 73.5% for the RIRS group after first procedure (P < .001). Nomajor complication (Clavien III-V) occurred in the RIRS group. CONCLUSION: Although the primary treatment method for renal stones ≥ 2cm size is PNL, serious complicationscan be seen. Therefore, RIRS can be an alternative treatment option in the management of renal stones ≥2 cm size.


Subject(s)
Kidney Calculi/surgery , Nephrostomy, Percutaneous , Female , Humans , Kidney/surgery , Male , Middle Aged , Retrospective Studies , Treatment Outcome , Urologic Surgical Procedures/methods
6.
Urol Case Rep ; 3(3): 80-1, 2015 May.
Article in English | MEDLINE | ID: mdl-26793509

ABSTRACT

Penile prosthesis is a functional option for patients who have erectile dysfunction after failed medical and intracavernosal treatments. Malleable penile prosthesis is a good alternative. Penile prosthesis implantation is a surgical process. Seldomly complications occur. In this study we presented a 61 y old man who has malfunctioned and broken penile prosthesis due to cross implantation.

7.
Biomed Res Int ; 2014: 691946, 2014.
Article in English | MEDLINE | ID: mdl-25295266

ABSTRACT

PURPOSE: To compare the effectiveness and safety of retroperitoneal laparoscopic ureterolithotomy (RLU) and percutaneous antegrade ureteroscopy (PAU) in which we use semirigid ureteroscopy in the treatment of proximal ureteral stones. METHODS: Fifty-eight patients with large, impacted stones who had a history of failed shock wave lithotripsy (SWL) and, retrograde ureterorenoscopy (URS) were included in the study between April 2007 and April 2014. Thirty-seven PAU and twenty-one RLU procedures were applied. Stone-free rates, operation times, duration of hospital stay, and follow-up duration were analyzed. RESULTS: Overall stone-free rate was 100% for both groups. There was no significant difference between both groups with respect to postoperative duration of hospital stay and urinary leakage of more than 2 days. PAU group had a greater amount of blood loss (mean hemoglobin drops for PAU group and RLU group were 1.6±1.1 g/dL versus 0.5±0.3 g/dL, resp.; P=0.022). RLU group had longer operation time (for PAU group and RLU group 80.1±44.6 min versus 102.1±45.5 min, resp.; P=0.039). CONCLUSIONS: Both PAU and RLU appear to be comparable in the treatment of proximal ureteral stones when the history is notable for a failed retrograde approach or SWL. The decision should be based on surgical expertise and availability of surgical equipment.


Subject(s)
Laparoscopy/methods , Lithotripsy/methods , Ureteral Calculi/surgery , Ureteroscopy/methods , Adolescent , Adult , Aged , Female , Humans , Length of Stay , Male , Middle Aged , Operative Time , Ureteral Calculi/pathology
8.
Drug Des Devel Ther ; 7: 1-6, 2013.
Article in English | MEDLINE | ID: mdl-23300343

ABSTRACT

BACKGROUND: The purpose of this study was to determine the effectiveness of a single early instillation of mitomycin C (MMC) after transurethral resection of bladder tumor (TURBT) together with urinary alkalinization in patients with low-risk non-muscle-invasive bladder cancer (NMIBC). METHODS: Between February 2006 and November 2010, patients diagnosed as having a primary bladder tumor were randomized into standard and optimized treatment groups. The treatment groups were formed prospectively from patients with NMIBC according to results of pathological examination postoperatively, whereas the control group was formed retrospectively. Patients in the standard group (n = 11) were given intravesical MMC 40 mg in the first 6 hours after TURBT, while the patients in the optimized group (n = 15) underwent urinary alkalinization prior to MMC. In the control group (n = 23), no drug treatment was given. The patients were followed after surgery at months 3 and 12, and then annually for the first 5 years using cystoscopy and ultrasound. Time to recurrence and recurrence-free survival rates were calculated. RESULTS: There were no statistically significant differences between the standard and optimized groups, between the control and optimized groups, or between the control and standard groups in terms of mean recurrence-free survival rates (P = 0.132, 0.645, and 0.173, respectively). The mean time to recurrence was 34.8 (range 28.5-41.1) months in the optimized group and 51.8 (range 44.3-59.2) months in the control group. There was no recurrence during the follow-up period in the standard group. CONCLUSION: The results of this preliminary study could not demonstrate the efficacy of urinary alkalinization before a single dose of early MMC following TURBT to increase the effectiveness of the MMC, so we did not continue the study further.


Subject(s)
Antibiotics, Antineoplastic/therapeutic use , Mitomycin/therapeutic use , Sodium Bicarbonate/administration & dosage , Urinary Bladder Neoplasms/drug therapy , Administration, Intravesical , Adult , Aged , Antibiotics, Antineoplastic/administration & dosage , Cystoscopy , Disease-Free Survival , Female , Follow-Up Studies , Humans , Male , Middle Aged , Mitomycin/administration & dosage , Neoplasm Recurrence, Local , Prospective Studies , Time Factors , Treatment Outcome , Urinary Bladder Neoplasms/pathology , Urinary Bladder Neoplasms/surgery
9.
Drug Des Devel Ther ; 6: 187-94, 2012.
Article in English | MEDLINE | ID: mdl-22888219

ABSTRACT

PURPOSE: There is currently an emerging need for developing improved approaches for preventing urinary tract infections (UTIs) occurring during diagnostic or interventional procedures of the lower urinary tract. We aimed to establish a rat model to assess the use of transurethral antibiotic administration and to provide evidence that this could be used as a preventive therapy. METHODS: Animals received fosfomycin trometamol (FOF) either urethrally or orally prior to the procedure. A third group was generated as treatment controls and did not receive any medication. Urethral dilation was conducted to recapitulate an interventional procedure prior to intravesical Escherichia coli administration in all three groups. Finally, sham-operated animals were introduced as a fourth group which did not receive antibiotics or E. coli. Colony counts of urine and tissue cultures for the identification of E. coli and histopathological examinations of the bladder and prostate were conducted. RESULTS: Evaluation of infection intensities in cultures as well as histopathological examination of the bladder and prostate demonstrated a preventative role of transurethral FOF administration. In terms of efficiency, local administration of FOF was similar to oral administration. CONCLUSIONS: These results suggest that transurethral antibiotic administration is a promising alternative for preventing UTIs occurring during diagnostic or interventional procedures of the lower urinary tract.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Escherichia coli Infections/prevention & control , Fosfomycin/therapeutic use , Urinary Tract Infections/prevention & control , Administration, Oral , Animals , Anti-Bacterial Agents/administration & dosage , Colony Count, Microbial , Disease Models, Animal , Escherichia coli/isolation & purification , Escherichia coli Infections/microbiology , Fosfomycin/administration & dosage , Male , Rats , Rats, Wistar , Urethra/metabolism , Urinary Tract Infections/microbiology
10.
Asian J Androl ; 14(5): 784-7, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22796737

ABSTRACT

Acute ST elevation myocardial infarction has high mortality and morbidity rates. The majority of patients with this condition face erectile dysfunction in addition to other health problems. In this study, we aimed to investigate the effects of two different reperfusion strategies, primary angioplasty and thrombolytic therapy, on the prevalence of erectile dysfunction after acute myocardial infarction. Of the 71 patients matching the selection criteria, 45 were treated with primary coronary angioplasty with stenting, and 26 were treated with thrombolytic agents. Erectile function was evaluated using the International Index of Erectile Function in the hospital to characterize each patient's sexual function before the acute myocardial infarction and 6 months after the event. The time required to restore blood flow to the artery affected by the infarct was found to be associated with the occurrence of erectile dysfunction after acute myocardial infarction. The increase in the prevalence of erectile dysfunction after acute myocardial infarction was 44.4% in the angioplasty group and 76.9% in the thrombolytic therapy group (P=0.008). In conclusion, this study has shown that reducing the time of reperfusion decreases the erectile dysfunction prevalence, and primary angioplasty is superior to thrombolytic therapy for decreasing the prevalence of erectile dysfunction after acute myocardial infarction.


Subject(s)
Angioplasty , Erectile Dysfunction/therapy , Myocardial Infarction/complications , Thrombolytic Therapy , Adult , Electrocardiography , Erectile Dysfunction/etiology , Humans , Male , Middle Aged , Myocardial Infarction/physiopathology
11.
J Endourol ; 26(6): 630-4, 2012 Jun.
Article in English | MEDLINE | ID: mdl-21999400

ABSTRACT

BACKGROUND AND PURPOSE: Nephrostomy tract dilation is one of the important steps in percutaneous renal surgery. We present our experiences with using Amplatz and metal telescopic dilators (Alken) to create a percutaneous tract and compare the advantages and risk factors of both procedures. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 173 patients who had undergone 188 percutaneous nephrolithotomy procedures between April 2007 and December 2010. The nephrostomy tracts had been created by using Amplatz (67 cases) or Alken dilators (121 cases). Total operative time, scope time, tract formation time, decrease in hemoglobin concentrations, blood transfusion rates, tract dilation failures, and the cost of both systems were compared between the groups. RESULTS: There were no statistically significant differences in total operative time (103.3 ± 46.5 vs 99.1 ± 44.4 min, P=0.583), scope time (5.23 ± 3.06 vs 5.28 ± 2.52 min, P=0.732), decrease in hemoglobin concentration (-1.5 ± 1.2 vs-1.3 ± 1.1 mg/dL, P=0.230), blood transfusion rates (13.4% vs 11.6%, P=0.709), and tract dilation failure rates (6.0% vs 1.7%, P=0.107) for Amplatz and Alken dilation groups, respectively. A shorter tract formation time (6.56 ± 3.04 vs 5.42 ± 3.07 min, P<0.001) was observed in the Alken dilation group. The approximate costs per each case were $220 and $7.25 for Amplatz and Alken dilation groups, respectively. CONCLUSIONS: The Alken dilation technique produces similar results to the Amplatz dilators in terms of efficiency, safety, and total operative time. Notwithstanding, it is more cost-effective in comparison.


Subject(s)
Dilatation/instrumentation , Dilatation/methods , Metals , Nephrostomy, Percutaneous/instrumentation , Nephrostomy, Percutaneous/methods , Telescopes , Adolescent , Adult , Aged , Blood Transfusion/statistics & numerical data , Child , Child, Preschool , Demography , Female , Humans , Male , Middle Aged , Treatment Outcome , Young Adult
12.
Clin Genitourin Cancer ; 9(2): 73-80, 2011 Dec.
Article in English | MEDLINE | ID: mdl-22035833

ABSTRACT

Much progress has been made toward an understanding of the development and progression of prostate cancer (PC) and the factors that drive the development of androgen independence. Neuroendocrine (NE) cells may provide an intriguing link between NE cell differentiation (NED) and tumor progression in PC. NED in PC generally confers a more aggressive clinical behavior and less favorable prognosis than conventional PC. In this article, we review the known functions of NE cells in PC and discuss the current knowledge on stimulation of cancer proliferation, invasion, apoptosis resistance, serum and immunohistochemical markers, and the prognostic significance of NED in human PC.


Subject(s)
Adenocarcinoma/pathology , Neuroendocrine Cells/pathology , Prostatic Neoplasms/pathology , Adenocarcinoma/mortality , Cell Differentiation , Humans , Male , Prognosis , Prostatic Neoplasms/mortality
13.
Clin Invest Med ; 34(3): E179-83, 2011 Jun 01.
Article in English | MEDLINE | ID: mdl-21631995

ABSTRACT

PURPOSE: Testicular spermatozoa can be retrieved successfully by the testicular sperm extraction (TESE) procedure and used for intracytoplasmic sperm injection. Disruption in the blood-testis barrier can lead to the production of antisperm antibodies (ASA). The aim of this prospective study was to investigate the frequency of ASA formation in couples after TESE procedure. METHODS: Thirty-seven couples were included in the study at the Urology Clinic of the Dr. Zekai Tahir Burak Women's Health Training and Research Hospital. History, physical examination, spermiogram, and endocrine profiles were obtained for all male patients. All the male patients in this study had been diagnosed with nonobstructive azoospermia (NOA) and underwent microdissection TESE. Secondary and tertiary cases were also included in the study. Serum samples were obtained from all 74 patients before TESE, and at three and 12 months after TESE. Serum ASA levels were determined. ANOVA was performed for statistical analysis for serum Follicle-Stimulating Hormone (FSH), testosterone and testicular volume. P < 0.05 was considered significant. RESULTS: There were no differences in the testicular volumes, serum FSH and testosterone levels before and after TESE. None of the patients or their partners developed significant levels of ASA as a result of the TESE procedure. CONCLUSION: TESE procedure does not cause ASA production in either males or their female partners.


Subject(s)
Autoantibodies/blood , Sperm Retrieval/adverse effects , Adult , Azoospermia/blood , Female , Follicle Stimulating Hormone/blood , Humans , Male , Testosterone/blood
14.
Urol Int ; 87(1): 35-41, 2011.
Article in English | MEDLINE | ID: mdl-21654152

ABSTRACT

BACKGROUND: To evaluate the use of NMP22 BladderChek® (NMP22BC) as an initial test in comparison to voided urine cytology for screening subjects with asymptomatic microscopic hematuria (AMH); those who are <40 years of age and have a low risk for bladder cancer based on a non-smoking history, and by discussing the guidelines on this subject. METHODS: From October 2005 to September 2007, 164 patients (56 male, 108 female) were evaluated. Patients with risk factors according to AUA Best Practice Policy Recommendations on AMH were strictly excluded from the study. For upper urinary tract imaging, ultrasonography (USG) was performed and prior to the cystoscopic procedure freshly voided urine was sampled for urine cytology and NMP22BC assay in all patients. Biopsy was performed if suspicious lesions were seen or positive cytology was obtained. RESULTS: The mean age was 30.8 years. As some benign urological pathologies were detected in 21 patients by USG, NMP22BC was positive in 26 patients where the cytology was confirmed as atypia in 5. Two TaG1 tumors were detected cystoscopically in a 39-year-old man and a 33-year-old woman where the NMP22BC test was positive and the cytology was negative in both patients. NMP22BC tests sensitivity, PPV and NPV values were detected to be higher compared to cytology and the likelihood ratio was 6.75. CONCLUSION: We recommend in evaluation of low-risk patients with AMH that, as an initial test, two non-invasive and cost-effective methods be chosen: an upper tract imaging by USG as recommended by guidelines, followed by an NMP22BC test for lower tract investigation instead of urine cytology.


Subject(s)
Hematuria/etiology , Nuclear Proteins/urine , Reagent Kits, Diagnostic , Urologic Neoplasms/diagnosis , Adult , Asymptomatic Diseases , Biomarkers, Tumor/urine , Biopsy , Cystoscopy , Female , Hematuria/diagnostic imaging , Hematuria/urine , Humans , Male , Patient Selection , Point-of-Care Systems , Practice Guidelines as Topic , Predictive Value of Tests , Prospective Studies , Risk Assessment , Risk Factors , Sensitivity and Specificity , Turkey , Ultrasonography , Urine/cytology , Urologic Neoplasms/complications , Urologic Neoplasms/diagnostic imaging , Urologic Neoplasms/urine , Young Adult
15.
Arch Med Sci ; 6(3): 382-7, 2010 Jun 30.
Article in English | MEDLINE | ID: mdl-22371775

ABSTRACT

INTRODUCTION: The aim of study is determining the cost-effectiveness of detection analysis in the presence of exceptional patients who have mild semen disorders, and beware of unnecessary varicocele repairs; and to ascertain whether patients with clinical varicocele should undergo Y chromosome (Yq) microdeletion analysis as a routine procedure. MATERIAL AND METHODS: Varicocele with reflux was diagnosed in 51 male patients with subfertility symptoms upon physical examination (PE), confirmed by scrotal colour-Doppler ultrasound (CDU). After cytogenetic examination, Yq microdeletion analysis was performed on the peripheral blood samples using Promega Y Chromosome Deletion Detection System Version 2. Varicocele repair was performed under general anaesthesia with optical magnification (3-fold) through a subinguinal approach. RESULTS: The mean age of the patients was 27.9. Values of semen concentration ranged from 0 to 72 million/ml, motility from 0 to 65% (A + B) and Kruger from 0% to 18%. The PE revealed normal size and consistency in the bilateral testicles. All patients were cytogenetically normal. However, Yq microdeletion was detected in 2 patients, 1 with mild oligoteratozoospermia and partial AZFb deletion (sY121) and the second patient with severe oligozoospermia and partial AZFc deletion (sY254 and sY255), and they were not subjected to varicocelectomy. CONCLUSIONS: The routine performance of pre-operative Yq microdeletion analysis in patients with clinical varicocele does not seem to be cost-effective but the omission of patients with mild oligozoospermia would have subjected them to an unnecessary varicocelectomy and/or further ICSI applications and also would have caused the failure of referral for genetic counselling.

16.
Arch Med Sci ; 6(5): 787-92, 2010 Oct.
Article in English | MEDLINE | ID: mdl-22419940

ABSTRACT

INTRODUCTION: The aim was to examine the effect of a sedative or analgesic supplement to periprostatic nerve blockage (PNB) on pain reduction during probe insertion and needle penetration in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy. We also investigated the effects of this procedure on the positive response rate in re-biopsy. MATERIAL AND METHODS: One hundred TRUS-guided prostate biopsy patients due to prostate-specific antigen (PSA) levels higher than 2.5 ng/ml and/or abnormal rectal examination findings were evaluated. Group 1 (PNB) was given periprostatic lidocaine injection before the procedure. Group 2 (analgesic) was given tramadol and PNB. Group 3 (sedative) was given midazolam and PNB. Group 4 (control) was not given any anaesthesia or analgesics. Pain scores were assessed during probe insertion and needle penetration by a visual analogue scale. RESULTS: During probe insertion, the mean pain score of the sedative group was lower than that of the control, analgesic and PNB groups (p < 0.001, p = 0.009, and p < 0.001, respectively). During needle penetration, the mean pain score of the control group was higher than that of the other groups (p < 0.001). The rate of positive response to re-biopsy was found to be 56% in the control group and between 92% and 100% in the other three groups (p < 0.001). CONCLUSION: According to our results, it can be concluded that midazolam, given supplementary to PNB, contributes as an effective and safe alternative for pain control during both probe insertion and penetration of the biopsy needle into the prostate capsule; however, tramadol supplement does not provide any additional contributions.

17.
Int J Surg Pathol ; 18(4): 248-54, 2010 Aug.
Article in English | MEDLINE | ID: mdl-19793829

ABSTRACT

The aim of the present study was to determine how the modified Gleason grading (mGG) system affects the score discrepancy between needle biopsy (NB) and radical prostatectomy (RP) and to investigate the effect of the modified scores on nomogram predictions. When the conventional Gleason grading (cGG) and mGG systems were compared, a new Gleason score was obtained in the NBs for 40 out of 97 patients (41.2%; P < .001) and in the RP specimens for 15 out of 97 patients (15.5%; P = .005). The agreement between the NBs and RP specimens rose from 31.9% to 44.3% with the mGG system (P = .017). However, when the predictions calculated with the location of modified Gleason scores in the Memorial Sloan Kettering Cancer Center nomogram were compared with those of the conventional Gleason scores, higher pathological stage and lower life expectancy predictions were obtained. Therefore, when a clinician is making a choice from therapeutic options, this change should be taken into account.


Subject(s)
Adenocarcinoma/pathology , Prostatic Neoplasms/pathology , Urology/methods , Adenocarcinoma/classification , Adenocarcinoma/surgery , Aged , Biopsy , Biopsy, Needle , Humans , Male , Middle Aged , Practice Patterns, Physicians' , Professional Practice , Prognosis , Prostatectomy , Prostatic Neoplasms/classification , Prostatic Neoplasms/surgery
18.
Clin Genitourin Cancer ; 7(2): E16-23, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19692317

ABSTRACT

BACKGROUND: This study was designed to investigate whether there is a correlation between interleukin (IL)-8 secretion rate and recurrences in induction bacillus Calmette-Guérin (BCG) immunotherapy following transurethral resection (TUR) in cases of primary non-muscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS: A total of 41 patients with NMIBC were randomized to receive a 6-week course with a standard dose of 81 mg intravesical BCG. Voided urine samples were collected immediately before and after (at 2 and 4 hours) BCG instillation. IL-8 was measured using enzyme-linked immunosorbent assay. Patients were monitored according to European Association of Urology Guidelines. RESULTS: Patients were monitored for a mean duration of 21.0 +/- 13.86 months. The mean time to recurrence for the 15 patients who had recurrences was 11.2 months. After adjusting for risk factors, the change in IL-8 levels at 2 hours after the first BCG compared with the levels before BCG instillation was found to be significantly predictive of recurrence (P = .047), and the best cutoff point was estimated as 112 pg/mL. The sensitivity of this measure for prediction of recurrences was 53.3%, specificity was 88.5%, positive predictive value was 72.7%, and negative predictive value was 76.7%. Comparison of patients who had values below and above this cutoff point revealed that the recurrence-free survival rate was 76.7% versus 27.3%, and the expected recurrence-free survival time was 34.9 months versus 18.8 months (P = .006). CONCLUSION: Besides numerous other prognostic factors that have been suggested so far, a cutoff point of 112 pg/mL for IL-8 levels measured 2 hours after the first BCG instillation appears to be a good predictive factor for successful outcome in BCG treatment following TUR.


Subject(s)
BCG Vaccine/therapeutic use , Interleukin-8/urine , Neoplasm Recurrence, Local/urine , Urinary Bladder Neoplasms/therapy , Adult , Aged , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Predictive Value of Tests , Sensitivity and Specificity , Urinary Bladder Neoplasms/urine , Urologic Surgical Procedures
19.
ScientificWorldJournal ; 8: 586-97, 2008 Jun 13.
Article in English | MEDLINE | ID: mdl-18604442

ABSTRACT

We compared three different chemotherapy regimens containing epirubicin in hormone-refractory prostate cancer (HRPC) patients. Sixty-nine patients with HRPC were randomized into three groups. The first group (22 patients) received 30 mg/m2/week i.v. epirubicin for 8 weeks. The second group (24 patients) received 30 mg/m2/week i.v. epirubicin for 8 weeks followed by monthly maintenance therapy for 4-6 months. The third group (23 patients) received oral estramustine phosphate (EMP) at a dose of 840 mg/day together with weekly and monthly maintenance epirubicin. The response rates, mean survival times, and toxicity were determined. Within the first 3 months, pain and performance scores were improved by at least one degree in all the groups. One patient in group two and three patients in group three had complete response. Partial response rates were 23% in group 1, 25% in group 2, and 17% in group 3. Stable disease rates were 41% in group 1, 33% in group 2, and 26% in group 3. The progression rates within the first 3 months were 36% in group 1, 38% in group 2, and 44% in group 3. None of the patients developed complications that were significant enough to terminate the treatment. Two patients in group 3 died of cardiotoxicity. The mean survival times were 10.1, 15.8, and 16.1 months in groups 1, 2, and 3, respectively. It was determined that weekly and maintenance epirubicin treatment protocol, and estramustine treatment protocol in addition to this treatment, was only meaningfully more effective against weekly epirubicin treatment in the statistical sense (0.01 < p < 0.05). However, due to the complications of EMP, which influence the quality of life, we believe that this was usable only when measures were adopted against these effects.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Epirubicin/therapeutic use , Prostatic Neoplasms/drug therapy , Aged , Aged, 80 and over , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Disease Progression , Epirubicin/administration & dosage , Epirubicin/adverse effects , Humans , Male , Middle Aged , Prostatic Neoplasms/pathology , Quality of Life , Survival Analysis , Treatment Outcome
20.
J Endourol ; 22(8): 1721-3, 2008 Aug.
Article in English | MEDLINE | ID: mdl-18657039

ABSTRACT

The inability to remove a urethral catheter because of inadvertent stitching or entrapped sutures after radical retropubic prostatectomy is rarely reported in the literature. Various methods are recommended to solve this problem. Here, we discuss a method developed by using a pediatric optical urethrotome to remove endoscopically a Foley urethral catheter that was encircled by a vesicouretheral anastomotic suture.


Subject(s)
Catheterization/adverse effects , Catheterization/methods , Prostatectomy/adverse effects , Sutures/adverse effects , Urethra/surgery , Humans , Male , Middle Aged
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