Subject(s)
Management Audit/methods , Organ Transplantation , Quality Assurance, Health Care/methods , Quality Control , Tissue and Organ Procurement/organization & administration , Humans , National Health Programs , Program Evaluation , Societies, Medical/standards , Spain , Tissue and Organ Procurement/standardsSubject(s)
Management Audit/statistics & numerical data , Organ Transplantation/statistics & numerical data , Quality Assurance, Health Care/statistics & numerical data , Quality Control , Tissue and Organ Procurement/statistics & numerical data , Humans , National Health Programs/statistics & numerical data , Program Evaluation , Quality Assurance, Health Care/methods , Societies, Medical/standards , Spain , Tissue and Organ Procurement/standardsABSTRACT
No disponible
No disponible
Subject(s)
Humans , Transplants , Societies, Medical/organization & administration , Tissue and Organ Procurement/organization & administration , SpainABSTRACT
No disponible
No disponible
Subject(s)
Humans , Organ Transplantation , Tissue and Organ Procurement/methods , Tissue and Organ Procurement/organization & administration , National Health Programs , Spain , Tissue DonorsABSTRACT
No disponible
No disponible
Subject(s)
Humans , Organ Transplantation , Tissue and Organ Procurement , National Health Programs , Societies, Medical/standards , Spain , Tissue Donors , Quality ControlABSTRACT
No disponible
No disponible
Subject(s)
Humans , Organ Transplantation/standards , Quality Control , Tissue and Organ Procurement/standards , National Health Programs , Program Evaluation , Societies, Medical/standards , SpainABSTRACT
No disponible
No disponible
Subject(s)
Humans , Organ Transplantation , /methods , Quality Control , Tissue and Organ Procurement/organization & administration , Tissue and Organ Procurement/standards , Management Audit/methods , National Health Programs , Program Evaluation , Societies, Medical/standards , SpainABSTRACT
No disponible
No disponible
Subject(s)
Humans , Management Audit/statistics & numerical data , Organ Transplantation/statistics & numerical data , /methods , /statistics & numerical data , Quality Control , Tissue and Organ Procurement/standards , Tissue and Organ Procurement/statistics & numerical data , National Health Programs/statistics & numerical data , Program Evaluation , Societies, Medical/standards , SpainABSTRACT
No disponible
No disponible
Subject(s)
Humans , Organ Transplantation/standards , Program Development , Program Evaluation , Tissue and Organ Procurement/standards , SpainABSTRACT
A study was made of the number of Langerhan's cells (LCs) per mm2 of section which express the antigens T6 and/or HLA-DR in seriated gingival sections of diphenylhydantoine-induced hyperplasia (HG) and clinically normal gingivae (NG). NG showed histological correlation with its macroscopic appearance. In HG the classical histopathological findings were verified, as well as the epithelial maturation irregularities, conductive to the development of epithelial gaps. In the immunostained samples, LCs appear amply distributed in the epithelium in greater numbers than in NG and more branched except in the immature areas, where they mostly express HLA-DR. In HG keratinocytes, HLA-DR+ are observed in the basal layer, except in developing epithelial gap zones. The Wilcoxon test for the NG-T6/NG-DR and HG-T6/HG-DR was not significant; but the Mann Whitney test for NG-T6/HG-T6 and NG-DR/HG-DR was significant to p less than 0.05. It is understood that the increase in LC numbers in HG is a manifestation of their active participation in local immune reactions. The presence of DR+/T6- LCs in the less keratinized areas seems to indicate the relationship of LCs with epithelial proliferation and/or differentiation.
Subject(s)
Gingival Hyperplasia/pathology , Langerhans Cells/pathology , Phenytoin/adverse effects , Adult , Antigens, CD , Antigens, CD1 , Cell Count , Gingiva/cytology , Gingival Hyperplasia/chemically induced , Gingival Hyperplasia/immunology , HLA-DR Antigens , Humans , Langerhans Cells/immunology , Male , Middle AgedABSTRACT
The number/mm2 of sections of Langerhans cells (LC's) expressing antigens T6 and/or HLA-DR was determined in eight human gingival samples which consisting of normal gingivae, contraceptive induced hyperplastic, traumatic, inflammatory and diphenylhydantoin hyperplasic gingivae. All samples, except those from normal gingivae, showed inflammatory and/or hyperplasic histopathological patterns. In the immunostained samples, LC's appeared in variable numbers and were randomly distributed between the keratinocytes. All pathological samples, except the inflammatory gingiva showed HLA-DR+ keratinocytes. Wilcoxon and Mann-Whitney statistical tests suggested the existence of three subpopulations of LC's: T6+/DR+; T6-/DR+ and T6+/DR-. The subpopulation T6+/DR+ was predominant in conditions of normal immune response. The subpopulation T6-/DR+ suggested the presence of newly incorporated LC's from the lamina propia. T6+/DR- subpopulations could indicate the existence of a system to avoid overstimulation. It is concluded that quantitative evaluation of T6 and HLA-DR expression was representative of the gingival conditions and the disease activity.
Subject(s)
Antigens, CD/analysis , Antigens, Differentiation/analysis , Gingiva/cytology , Gingival Hyperplasia/pathology , Gingivitis/pathology , HLA-DR Antigens/analysis , Langerhans Cells/pathology , Adult , Antigens, CD1 , Cell Count , Contraceptive Agents/adverse effects , Culture Techniques , Female , Gingival Hyperplasia/chemically induced , Humans , Keratinocytes/immunology , Keratinocytes/pathology , Langerhans Cells/immunology , Male , Phenytoin/adverse effectsABSTRACT
A case of benign fibrohistiocytoma of the soft palate in a 61 years-old woman is presented and current approaches to histogenesis of fibro-histiocytic tumors commented.
