ABSTRACT
INTRODUCCIÓN: la coledocolitiasis puede ser primaria (cálculos formados originalmente en la vía biliar) o secundaria (cálculos que han migrado de la vesícula biliar al colédoco). Nuestro objetivo fue estudiar las diferencias clínicas entre ambos tipos de coledocolitiasis en pacientes colecistectomizados. MATERIAL Y MÉTODOS: estudio comparativo y retrospectivo en el que se compararon pacientes colecistectomizados que presentaron coledocolitiasis. Se definió como coledocolitiasis residual o secundaria (grupo 1) la que apareció en los dos primeros años tras la colecistectomía y coledocolitiasis primaria (grupo 2) la que apareció después de los dos primeros años tras la colecistectomía. La coledocolitiasis se confirmó mediante colangiopancreatografía retrógrada endoscópica (CPRE) o cirugía. RESULTADOS: los pacientes con coledocolitiasis primaria (n = 14) tuvieron mayor edad (61,5 ± 20,3 vs. 74,4 ± 10,5 años; p = 0,049), mayor índice de masa corporal (IMC) (27,7 ± 4,3 vs. 31,6 ± 4,6 kg/m2; p = 0,043) y mayor diámetro de la vía biliar extrahepática (10,7 ± 2,7 vs. 14,7 ± 3,5 mm; p = 0,004) respecto a los pacientes con coledocolitiasis residual o secundaria (n = 11). Todos los pacientes fueron tratados mediante CPRE. No hubo diferencias entre los grupos 1 y 2 en cuanto a recidivas (36,2 % vs. 14,3 %; p = 0,350), intervalo libre de enfermedad (64,6 ± 30,9 vs. 52,2 ± 37,7 meses; p = 0,386) y supervivencia global (73,6 ± 32,4 vs. 54 ± 41,9 meses; p = 0,084). CONCLUSIONES: los pacientes con coledocolitiasis primaria presentan mayor edad, mayor IMC y mayor diámetro de la vía biliar respecto a los pacientes con coledocolitiasis residual o secundaria. La CPRE es una buena opción terapéutica para la resolución de ambos tipos de coledocolitiasis
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Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Choledocholithiasis/surgery , Choledocholithiasis/etiology , Cholangiopancreatography, Endoscopic Retrograde , Kaplan-Meier Estimate , Retrospective Studies , CholecystectomyABSTRACT
INTRODUCTION: choledocholithiasis can be primary from stones originally formed in the choledocho or secondary from stones that have migrated from the gallbladder to the choledocho. The objective of this study was to determine the clinical differences between both types of choledocholithiasis in cholecystectomy patients. MATERIAL AND METHODS: a comparative and retrospective study was performed of cholecystectomy patients who presented choledocholithiasis. Residual or secondary choledocholithiasis (group 1) was defined as those which appear in the first two years after cholecystectomy and primary choledocholithiasis (group 2) was defined as those which appear two years after cholecystectomy. Choledocholithiasis was confirmed by endoscopic retrograde cholangiopancreatography (ERCP) or surgery. RESULTS: patients with primary choledocholithiasis (n = 14) were older (61.5 ± 20.3 vs 74.4 ± 10.5 years; p = 0.049) and had a greater body mass index (BMI) (27.7 ± 4.3 vs 31.6 ± 4.6 kg/m2; p = 0.043) and a larger extrahepatic bile duct diameter (10.7 ± 2.7 vs 14.7 ± 3.5 mm; p = 0.004) compared to patients with residual or secondary choledocholithiasis (n = 11). All patients were treated by ERCP. There were no differences between groups 1 and 2 regarding recurrences (36.2 % vs 14.3 %; p = 0.350), disease-free survival (64.6 ± 30.9 vs 52.2 ± 37.7 months; p = 0.386) and overall survival (73.6 ± 32.4 vs 54 ± 41.9 months; p = 0.084). CONCLUSIONS: patients with primary choledocholithiasis were older and had a greater BMI and a larger diameter of the bile duct compared to patients with residual or secondary choledocholithiasis. ERCP is a good therapeutic option for the resolution of both types of choledocholithiasis.
Subject(s)
Cholecystectomy, Laparoscopic , Choledocholithiasis , Cholangiopancreatography, Endoscopic Retrograde , Cholecystectomy , Choledocholithiasis/diagnostic imaging , Choledocholithiasis/surgery , Humans , Neoplasm Recurrence, Local , Retrospective StudiesABSTRACT
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Subject(s)
Humans , Male , Middle Aged , Gallbladder Neoplasms/diagnostic imaging , Gallbladder Neoplasms/secondary , Melanoma/diagnostic imaging , Melanoma/pathology , Gallbladder Neoplasms/therapy , Antineoplastic Agents, Immunological/administration & dosage , Cholecystectomy, Laparoscopic , Follow-Up Studies , Nivolumab/administration & dosageABSTRACT
Melanoma metastasizes to the gastrointestinal tract in 2-4% of cases. In addition, it is the tumor that most frequently metastasizes to the gallbladder (50-67% of metastasis at this level). Even so, these metastases are infrequent. The indication of cholecystectomy will be provided by the patient performance status, extension and prognosis of disease. Although open surgery is preferred to treat melanoma metastasis at this level, laparoscopic surgery could be a safe technique that allows a fast recovery of the patient. We present the case of a 48-year-old man with melanoma metastases in the gallbladder treated by laparoscopic cholecystectomy.
