Knowledge, attitudes and practices on tuberculosis among screened immigrants in Norway. A cross-sectional study.

Aims: Most tuberculosis (TB) cases in Norway occur among immigrants from high-incidence countries. Although there is an extensive screening program for vulnerable groups, many do not appear for their screening appointment and do not understand why they require screening. This study aimed to further understand these vulnerable groups' knowledge, attitudes and practices (KAP) regarding TB to inform the screening program and health care personnel dealing with TB. Methods: A KAP questionnaire developed by the World Health Organization (WHO) and adjusted to Norwegian conditions was used. The study has a cross-sectional design. One study group was immigrant students receiving primary screening in the municipality (MVIC) who completed an English questionnaire; the other was immigrants who were referred to hospital (POPD) for follow-up of screening results. They were interviewed with a translator when necessary. Statistical analyses to describe and compare groups of participants were done. Results: Altogether, 275 persons were eligible, and 219 (85%) participated. In the MVIC group 184 persons (86%) participated and in the POPD group 35 persons (80%). The mean knowledge score was 5.53 (maximum score: 11) with no significant differences between study groups or associations with demographics or length of education. There were serious knowledge gaps related to TB symptoms and transmission. Approximately half would have reacted with fear or surprise if they had TB, and 60% were afraid of being infected. Only 14% would avoid a person with TB. Conclusion: The mean knowledge score was reasonably good but with some serious knowledge gaps. We detected fear of being infected or having TB disease but no serious stigma. More information and teaching about TB catered towards different immigrant groups are necessary.

Rapid elimination of SARS-CoV-2 in a fully vaccinated patient. / Rask eliminasjon av SARS-CoV-2 hos fullvaksinert pasient.

High SARS-CoV-2 viral loads in respiratory secretions detected by PCR technique are usually an indicator of high transmission risk, but not always. In this article, we present the case of a fully-vaccinated patient with rapid clearance of the alpha variant of the virus.

Large outbreak of mumps virus genotype G among vaccinated students in Norway, 2015 to 2016.

From 6 September 2015-May 2016, a large mumps outbreak occurred among vaccinated students in Norway. A case was defined as a person presenting with a clinical mumps infection, notified between 1 September 2015 and 30 June 2016. Confirmed cases had positive laboratory confirmation and probable cases had an epidemiological link; PCR-positive specimens were genotyped. A total of 232 cases were notified (230 confirmed) with median age of 23 years (range 4-81) and 61% were male. Of 68 (30%) confirmed cases that were genotyped, 66 were genotype G and associated with the outbreak. Cases that had received two doses of the measles-mumps-rubella (MMR) vaccine had reduced risk of hospitalisation (adjusted relative risk (aRR): 0.14; 95%CI: 0.03-0.57), mumps-related orchitis (aRR: 0.21; 95% CI: 0.08-0.55) and severe outcome (aRR: 0.25; 95% CI: 0.10-0.62) compared with those unvaccinated. A third dose of the vaccine was offered to approximately 1,300 fully vaccinated close contacts and subsequently reported cases decreased. This large outbreak, occurring among predominately vaccinated students, suggests the current genotype A vaccine offers suboptimal protection against mumps genotype G. We recommend maintaining high vaccination coverage and offering the vaccine to all unvaccinated individuals.

Collaboration between municipal and specialist public health care in tuberculosis screening in Norway.

BACKGROUND: About 90% of new tuberculosis (TB) cases in Norway appear among immigrants from high incidence countries. There is a compulsory governmental tuberculosis screening programme for immigrants; immigrants with positive screening results are to be referred from municipal health care to the specialist health care for follow-up. Recent studies of the screening programme have shown inadequate follow-up. One of the main problems has been that patients referred for follow-up have not attended their appointment at the specialist health care.TB screening in the municipality of Trondheim is done by two different teams: the Refugee Healthcare Centre (RHC) screens refugees and the Vaccination and Infection Control Office (VICO) screens all the other groups. Patients with positive findings on screening are referred to the hospital's Pulmonary Out-patient Department (POPD). The municipal and referral level public health care initiated a project aiming to improve follow-up through closer collaboration. METHODS: An intervention group and a pre-intervention control group were established for each screening group. During meetings between staff from the municipality and the POPD, inadequacies in the screening process were identified, and changes in procedures for summoning patients, and time and place for tests were implemented. For both the intervention group and the control group, time from referral until consultation at the POPD and number of patients that attended their first appointment were registered and compared. RESULTS: In the VICO group, 97/134 (72%) of the controls and 109/123 (89%) of the intervention group attended their first appointment at the POPD after 30 weeks (median) and 10 weeks, respectively. In the RHC group 28/46 (61%) of the controls and 55/59 (93%) in the intervention group attended their first appointment after 15 and 8 weeks (median) respectively. CONCLUSION: Increased collaboration between the municipal and specialist health care can improve the follow-up of positive TB screening results.

Risk of developing tuberculosis after brief exposure in Norwegian children: results of a contact investigation.

OBJECTIVE: Prolonged exposure to adults with pulmonary tuberculosis is a risk factor for infecting children. We have studied to what extent a brief exposure may increase the risk of being infected in children. DESIGN: Observational study of a tuberculosis contact investigation. SETTING: 7 day-care centres and 4 after-school-care centres in Norway. PARTICIPANTS: 606 1-year-old to 9-year-old children who were exposed briefly to a male Norwegian with smear-positive pulmonary tuberculosis. MAIN OUTCOME MEASURES: Number of children with latent and active tuberculosis detected by routine clinical examination, chest x-ray and use of a Mantoux tuberculin skin test (TST) and an interferon-γ release assay (IGRA). RESULTS: The children were exposed to a mean of 6.9 h (range 3-18 h). 2-3 months after the exposure, 11 children (1.8%) had a TST ≥6 mm, 6 (1.0%) had TST 4-5 mm, and 587 (97.2%) had a negative TST result. Two children (0.3%) with negative chest x-rays who were exposed 4.75 and 12 h, respectively, had a positive IGRA test result, and were diagnosed with latent tuberculosis. None developed active tuberculosis. CONCLUSIONS: Children from a high-income country attending day-care and after-school-care centres had low risk of being infected after brief exposure less than 18 h to an adult day-care helper with smear-positive pulmonary tuberculosis.

[Legionella in Trondheim, Norway--determining sources of contagion and tracing risk environments]. / Legionella i Trondheim - smitteoppsporing og miljøkartlegging.

BACKGROUND: Legionnaires' disease, most often a serious condition, is a relatively rare disease in Norway although in recent years it has been on the increase. Because of clinical and microbiological diagnostic difficulties, one can assume that the number of new cases reported is significantly too low. MATERIAL AND METHOD: A multidisciplinary team established in the City of Trondheim has two main functions; first, to trace sources of contagion when outbreaks of the disease and detected; second, to carry out routine inspections in order to trace potential environmental sources. RESULTS: Over a four-year period (2001 - 2004), 19 cases of Legionnaires' disease were diagnosed; 17 of these are presumed to have originated locally. This is an incidence rate five times greater than the national average. Legionella pneumophila was discovered in the patients' local environment in 6 cases. Environmental investigations showed that the bacterium was present in three water-cooling towers, one Jacuzzi, one swimming pool, a shower in a factory, and in the hot-water system of a building complex. Most of the discoveries were made in the summer or autumn in several different locations in the city. Legionella pneumophila was found more often with low rather than high bacterial count, contrary to the information given in the Norwegian Legionnaires' disease prevention handbook. INTERPRETATION: Legionella pneumophila is in all likelihood a naturally occurring bacterium in many of the water sources and water supply plants in Trondheim. This requires continual awareness and readiness to tackle the disease. We have seen that a multidisciplinary team is well suited to evaluating high-risk environments, tracing outbreaks and carrying out information tasks targeted both at professionals and the public at large.