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1.
Fetal Pediatr Pathol ; 42(6): 972-978, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37584237

ABSTRACT

BACKGROUND: Giant congenital melanocytic nevus (GCMN) is characterized by its large size and potential for transformation into melanoma. It can be associated with other neural cristopathies, including neurofibroma, however, it has not previously been described with a congenital neurofibroma. CASE REPORT: A newborn girl presented with a large congenital neurofibroma arising in a bathing trunk type of giant congenital melanocytic nevus. CONCLUSION: Congenital neurofibromas can be associated with (or a component of) a GCMN.


Subject(s)
Melanoma , Neurofibroma , Nevus, Pigmented , Skin Neoplasms , Infant, Newborn , Female , Humans , Skin Neoplasms/diagnosis , Skin Neoplasms/congenital , Nevus, Pigmented/diagnosis , Nevus, Pigmented/congenital
2.
Fetal Pediatr Pathol ; 41(4): 643-650, 2022 Aug.
Article in English | MEDLINE | ID: mdl-33307929

ABSTRACT

BackgroundNeuroblastoma can arise from extra-adrenal sites in the paraspinal sympathetic chain, including the presacral region, where they must be differentiated from an immature or malignant neural lesion arising from a teratoma.Case ReportWe describe two congenital presacral neuroblastomas. The main clinical differential diagnoses were sacrococcygeal teratoma and meningomyelocele. Pathologically, they lacked teratomatous tissues, lacked germ cell serum markers, were localized without metastases, and were MYCN non-amplified. Both patients have done well without chemotherapy at 18 and 15 months of follow-up.ConclusionCongenital presacral neuroblastoma should be differentiated from teratomatous lesions, and in general have a good prognosis.


Subject(s)
Meningomyelocele , Neuroblastoma , Teratoma , Diagnosis, Differential , Humans , Meningomyelocele/pathology , Neuroblastoma/pathology , Sacrococcygeal Region/pathology , Teratoma/diagnosis , Teratoma/pathology
3.
J Org Chem ; 72(23): 8972-5, 2007 Nov 09.
Article in English | MEDLINE | ID: mdl-17924694

ABSTRACT

We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.


Subject(s)
Alkaloids/chemical synthesis , Antineoplastic Agents/chemical synthesis , Isoquinolines/chemical synthesis , Alkaloids/chemistry , Antineoplastic Agents/chemistry , Isoquinolines/chemistry , Magnetic Resonance Spectroscopy/methods , Magnetic Resonance Spectroscopy/standards , Molecular Conformation , Reference Standards , Stereoisomerism
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