Boosting capacitive performance of manganese oxide nanorods by decorating with three-dimensional crushed graphene.

This work reports the rational design of MnOx nanorods on 3D crushed reduced graphene oxide (MnOx/C-rGO) by chemical reduction of Ni-incorporated graphene oxide (GO) followed by chemical etching to remove Ni. The resulting MnOx/C-rGO composite synergistically integrates the electronic properties and geometry structure of MnOx and 3D C-rGO. As a result, MnOx/C-rGO shows a significantly higher specific capacitance (Csp) of 863 F g-1 than MnOx/2D graphene sheets (MnOx/S-rGO) (373 F g-1) and MnOx (200 F g-1) at a current density of 0.2 A g-1. Furthermore, when assembled into symmetric supercapacitors, the MnOx/C-rGO-based device delivers a higher Csp (288 F g-1) than MnOx/S-rGO-based device (75 F g-1) at a current density of 0.3 A g-1. The superior capacitive performance of the MnOx/C-rGO-based symmetric device is attributed to the enlarged accessible surface, reduced lamellar stacking of graphene, and improved ionic transport provided by the 3D architecture of MnOx/C-rGO. In addition, the MnOx/C-rGO-based device exhibits an energy density of 23 Wh kg-1 at a power density of 113 Wkg-1, and long-term cycling stability, demonstrating its promising potential for practical application.

Enhancing the Accuracy of Non-Invasive Glucose Sensing in Aqueous Solutions Using Combined Millimeter Wave and Near Infrared Transmission.

We reported measurement results relating to non-invasive glucose sensing using a novel multiwavelength approach that combines radio frequency and near infrared signals in transmission through aqueous glucose-loaded solutions. Data were collected simultaneously in the 37-39 GHz and 900-1800 nm electromagnetic bands. We successfully detected changes in the glucose solutions with varying glucose concentrations between 80 and 5000 mg/dl. The measurements showed for the first time that, compared to single modality systems, greater accuracy on glucose level prediction can be achieved when combining transmission data from these distinct electromagnetic bands, boosted by machine learning algorithms.

A smart switching system to enable automatic tuning and detuning of metamaterial resonators in MRI scans.

We present a radio-frequency-activated switching system that can automatically detune a metamaterial resonator to enhance magnetic resonance imaging (MRI) performance. Local sensitivity-enhancing metamaterials typically consist of resonant components, which means that the transmitted radio frequency field is spatially inhomogeneous. The switching system shows for the first time that a metamaterial resonator can be detuned during transmission and tuned during reception using a digital circuit. This allows a resonating system to maintain homogeneous transmit field while maintaining an increased receive sensitivity. As a result, sensitivity can be enhanced without changing the system-provided specific absorption rate (SAR) models. The developed digital circuit consists of inductors sensitive to the transmit radio-frequency pulses, along with diodes acting as switches to control the resonance frequency of the resonator. We first test the automatic resonator detuning on-the-bench, and subsequently evaluate it in a 1.5 T MRI scanner using tissue-mimicking phantoms. The scan results demonstrate that the switching mechanism automatically detunes the resonator in transmit mode, while retaining its sensitivity-enhancing properties (tuned to the Larmor frequency) in receive mode. Since it does not require any connection to the MRI console, the switching system can have broad applications and could be adapted for use with other types of MRI scanners and field-enhancing resonators.

Dielectric permittivity of human blood of different lactate levels measured at millimeter waves.

The investigation of variations in dielectric properties of blood based on its biochemical profile is important for determining the feasibility of developing electromagnetic non-invasive sensing systems for monitoring the levels of various metabolites in blood. In this paper, the real and imaginary parts of dielectric permittivity are measured as a function of lactate concentration in the 30-60 GHz frequency range using two different measurement techniques. The blood samples are collected from a healthy subject undergoing three different exercise modes and the dielectric properties are measured with an open-ended coaxial probe technique and a custom-made millimeter wave transmission system. Good correlation is observed in measurements from the two methods, suggesting that an increase in lactate concentration lowers the imaginary part of permittivity and thus causing higher attenuation.

Metasurface Resonator for 1.5 T MRI Based on BaTiO3 Host Material.

Magnetic resonance imaging (MRI) is a widely used clinical tool for medical diagnosis and therapy. Several research studies focus on passively improving MRI sensitivity using high dielectric constant (HDC) materials and metamaterials. In this work, we investigate a new metasurface resonator which can enhance local transmit and receive efficiency in 1.5T MRI. The metasurface has been realized with an array of non-magnetic rods embedded in two blocks of a BaTiO3 aqueous mixture. BaTiO3 when mixed with water exhibits high dielectric permittivity values in the 40-200 MHz range, allowing the design of a compact and safe device for practical use in an MRI scanner. Simulation results show 50% enhancement of the magnetic field in the region-of-interest. The resonance frequency of the metasurface is also validated experimentally with a small loop antenna and a vector network analyzer (VNA) in a laboratory-controlled environment.

A Glucose Sensing System Based on Transmission Measurements at Millimetre Waves using Micro strip Patch Antennas.

We present a sensing system operating at millimetre (mm) waves in transmission mode that can measure glucose level changes based on the complex permittivity changes across the signal path. The permittivity of a sample can change significantly as the concentration of one of its substances varies: for example, blood permittivity depends on the blood glucose levels. The proposed sensing system uses two facing microstrip patch antennas operating at 60 GHz, which are placed across interrogated samples. The measured transmission coefficient depends on the permittivity change along the signal path, which can be correlated to the change in concentration of a substance. Along with theoretical estimations, we experimentally demonstrate the sensing performance of the system using controlled laboratory samples, such as water-based glucose-loaded liquid samples. We also present results of successful glucose spike detection in humans during an in-vivo Intravenous Glucose Tolerance Test (IVGTT). The system could eventually be developed into a non-invasive glucose monitor for continuous monitoring of glucose levels for people living with diabetes, as it can detect as small as 1.33 mmol/l (0.025 wt%) glucose concentrations in the controlled water-based samples satisfactorily, which is well below the typical human glucose levels of 4 mmol/l.

A Low-Noise Transimpedance Amplifier for BLM-Based Ion Channel Recording.

High-throughput screening (HTS) using ion channel recording is a powerful drug discovery technique in pharmacology. Ion channel recording with planar bilayer lipid membranes (BLM) is scalable and has very high sensitivity. A HTS system based on BLM ion channel recording faces three main challenges: (i) design of scalable microfluidic devices; (ii) design of compact ultra-low-noise transimpedance amplifiers able to detect currents in the pA range with bandwidth >10 kHz; (iii) design of compact, robust and scalable systems that integrate these two elements. This paper presents a low-noise transimpedance amplifier with integrated A/D conversion realized in CMOS 0.35 µm technology. The CMOS amplifier acquires currents in the range ±200 pA and ±20 nA, with 100 kHz bandwidth while dissipating 41 mW. An integrated digital offset compensation loop balances any voltage offsets from Ag/AgCl electrodes. The measured open-input input-referred noise current is as low as 4 fA/√Hz at ±200 pA range. The current amplifier is embedded in an integrated platform, together with a microfluidic device, for current recording from ion channels. Gramicidin-A, α-haemolysin and KcsA potassium channels have been used to prove both the platform and the current-to-digital converter.

Characterization of the Prokaryotic Sodium Channel NavSp Pore with a Microfluidic Bilayer Platform.

This paper describes the use of a newly-developed micro-chip bilayer platform to examine the electrophysiological properties of the prokaryotic voltage-gated sodium channel pore (Na(v)Sp) from Silicibacter pomeroyi. The platform allows up to 6 bilayers to be analysed simultaneously. Proteoliposomes were incorporated into suspended lipid bilayers formed within the microfluidic bilayer chips. The chips provide access to bilayers from either side, enabling the fast and controlled titration of compounds. Dose-dependent modulation of the opening probability by the channel blocking drug nifedipine was measured and its IC50 determined.

Screening ion-channel ligand interactions with passive pumping in a microfluidic bilayer lipid membrane chip.

We describe a scalable artificial bilayer lipid membrane platform for rapid electrophysiological screening of ion channels and transporters. A passive pumping method is used to flow microliter volumes of ligand solution across a suspended bilayer within a microfluidic chip. Bilayers are stable at flow rates up to ∼0.5 µl/min. Phospholipid bilayers are formed across a photolithographically defined aperture made in a dry film resist within the microfluidic chip. Bilayers are stable for many days and the low shunt capacitance of the thin film support gives low-noise high-quality single ion channel recording. Dose-dependent transient blocking of α-hemolysin with ß-cyclodextrin (ß-CD) and polyethylene glycol is demonstrated and dose-dependent blocking studies of the KcsA potassium channel with tetraethylammonium show the potential for determining IC50 values. The assays are fast (30 min for a complete IC50 curve) and simple and require very small amounts of compounds (100 µg in 15 µl). The technology can be scaled so that multiple bilayers can be addressed, providing a screening platform for ion channels, transporters, and nanopores.

A Distributed Amplifier System for Bilayer Lipid Membrane (BLM) Arrays With Noise and Individual Offset Cancellation.

Lipid bilayer membrane (BLM) arrays are required for high throughput analysis, for example drug screening or advanced DNA sequencing. Complex microfluidic devices are being developed but these are restricted in terms of array size and structure or have integrated electronic sensing with limited noise performance. We present a compact and scalable multichannel electrophysiology platform based on a hybrid approach that combines integrated state-of-the-art microelectronics with low-cost disposable fluidics providing a platform for high-quality parallel single ion channel recording. Specifically, we have developed a new integrated circuit amplifier based on a novel noise cancellation scheme that eliminates flicker noise derived from devices under test and amplifiers. The system is demonstrated through the simultaneous recording of ion channel activity from eight bilayer membranes. The platform is scalable and could be extended to much larger array sizes, limited only by electronic data decimation and communication capabilities.

Application of terahertz spectroscopy to the characterization of biological samples using birefringence silicon grating.

We present a device and method for performing vector transmission spectroscopy on biological specimens at terahertz (THz) frequencies. The device consists of artificial dielectric birefringence obtained from silicon microfluidic grating structures. The device can measure the complex dielectric function of a liquid, across a wide THz band of 2 to 5.5 THz, using a Fourier transform infrared spectrometer. Measurement data from a range of liquid specimens, including sucrose, salmon deoxyribonucleic acid (DNA), herring DNA, and bovine serum albumin protein solution in water are presented. The specimen handling is simple, using a microfluidic channel. The transmission through the device is improved significantly and thus the measurement accuracy and bandwidth are increased.

Terahertz single pixel imaging based on a Nipkow disk.

We describe a terahertz single pixel imaging system based on a Nipkow disk. Nipkow disks have been used for fast scanning imaging systems since the first experimental television was invented in 1926. In our work, a Nipkow disk with 24 scanning lines was used to provide an axial resolution of 2 mm/pixel. We also show that by implementing a microscanning technique the axial resolution can be further improved to 0.5 mm/pixel. Imaging of several objects was demonstrated to show that this simple scanning system is promising for fast or real time terahertz imaging applications.

Method for vector characterization of polar liquids using frequency-domain spectroscopy.

A device for performing vector transmission spectroscopy on aqueous and polar solvent specimens at terahertz frequencies is presented. The device enables the direct measurement of the complex dielectric function across the terahertz band using a Fourier transform IR spectrometer for lossy solutions. Using microfluidic sampling, specimen handling is straightforward and direct measurements on polar specimens are made possible. The method is scalable to longer or shorter wavelengths.

Polarization insensitive, broadband terahertz metamaterial absorber.

We present the simulation, implementation, and measurement of a polarization insensitive broadband resonant terahertz metamaterial absorber. By stacking metal-insulator layers with differing structural dimensions, three closely positioned resonant peaks are merged into one broadband absorption spectrum. Greater than 60% absorption is obtained across a frequency range of 1.86 THz where the central resonance frequency is 5 THz. The FWHM of the device is 48%, which is two and half times greater than the FWHM of a single layer structure. Such metamaterials are promising candidates as absorbing elements for bolometric terahertz imaging.

A terahertz polarization insensitive dual band metamaterial absorber.

Metamaterial absorbers have attracted considerable attention for applications in the terahertz range. In this Letter, we report the design, fabrication, and characterization of a terahertz dual band metamaterial absorber that shows two distinct absorption peaks with high absorption. By manipulating the periodic patterned structures as well as the dielectric layer thickness of the metal-dielectric-metal structure, significantly high absorption can be obtained at specific resonance frequencies. Finite-difference time-domain modeling is used to design the structure of the absorber. The fabricated devices have been characterized using a Fourier transform IR spectrometer. The experimental results show two distinct absorption peaks at 2.7 and 5.2 THz, which are in good agreement with the simulation. The absorption magnitudes at 2.7 and 5.2 THz are 0.68 and 0.74, respectively.

Imprinted terahertz artificial dielectric quarter wave plates.

We have developed low-loss polymer artificial dielectric quarter wave plates (QWP) operating at 2.6, 3.2 and 3.8 THz. The QWPs are imprinted on high density polyethylene (HDPE) using silicon masters. The grating period for the quarter wave plates is 60 microm. 330 microm, 280 microm and 230 microm deep gratings are used to obtain a pi/2 phase retardance between TE and TM polarization propagating through the QWPs. High frequency structure simulator (HFSS) was used to optimize the grating depth. Since the required grating depth is high, two plates, fixed in a back-to-back configuration were used for each QWP. A maximum aspect ratio (grating height/grating width) of 6.6 was used.

Terahertz dual-band resonator on silicon.

We have designed and fabricated a dual-band resonator in the terahertz frequency range on high-resistivity silicon. The device is designed to show resonances at 2.6 and 4.3 THz using the finite-difference time-domain modeling method. The characteristics of the fabricated device have been examined by using a Fourier-transform IR spectrometer. Measured results are in excellent agreement with the simulated data, showing two polarization-independent resonant peaks observed at 2.60 and 4.37 THz, respectively. The first resonance has a bandwidth of 0.56 THz, while the second one has a bandwidth of 0.70 THz. These dual-band resonant devices can be used for various applications such as dual-band spectral imaging and multiband biosensors.