ABSTRACT
Four different frontal planes have been evaluated for their usefulness in considering the dose distribution from intracavitary applications for carcinoma of the uterine cervix, in relation to the subsequent planning of supplementary external beam therapy. For the primary tumour and its immediate zone of direct invasion the most useful planes are those passing through the radioactive sources in the body of the uterus. Not one of the planes examined gave satisfactory information concerning the dose in the regional lymph node areas. In order to combine the dose distributions from intracavitary and supplementary external beam irradiation, it is found that every case must be considered individually, particularly in regard to the degree of anterversion or retroversion of the uterus. The dose in the lymph nodes may be calculated directly from coordinates determined by the authors, for each specific regional lymph node group.
Subject(s)
Uterine Cervical Neoplasms/radiotherapy , Female , Humans , Lymph Nodes , Radiotherapy Dosage , UterusABSTRACT
Twenty-five patients with different histological variants of malignant tumours of the parotid gland have been treated by parotidectomy combined with interstitial radiotherapy with delayed afterloading and dose fractionation during the operation. The indications for this therapeutic approach and the techniques used are described. The follow-up of the patients ranging from one to over five years showed only two local recurrences, although most of the patients were in an advanced stage locally. Complications due to the irradiation have not been observed.
Subject(s)
Parotid Neoplasms/surgery , Adolescent , Adult , Aged , Child , Humans , Male , Middle Aged , Parotid Gland/surgery , Parotid Neoplasms/radiotherapy , Radiotherapy DosageABSTRACT
Investigative irradiations of human skin have shown that the total dose required to obtain a dry desquamation does not increase with the duration of the irradiation as rapidly as it would be expected from the kinetics of repair of the sublethal injuries. This suggests that an additional mechanism, probably accumulation of the cells in a sensitive phase, occurs during a continuous irradiation with dose-rate higher than 150 rads/hour. This effect seems to vanish at smaller dose-rates.
