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Transplant Proc ; 47(8): 2368-70, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26518929

ABSTRACT

BACKGROUND: Vascular calcification (VC) is known as an independent predictor of mortality in patients undergoing hemodialysis; nevertheless, there is a lack of studies about the impact of vascular calcification in renal transplant recipients, and none of them use the Kauppila Index (KI) as a predictor of patient and graft prognosis. METHODS: We conducted an observational, retrospective study of 119 renal transplants, evaluating abdominal aortic calcifications (L4-S1) with the KI. We established 2 categories: absence (KI = 0-2) and presence (KI = 3-24) of VCs before transplantation. We analyzed the impact of calcification in graft and patient survival, new-onset diabetes mellitus, hypertension, cardiovascular events, renal function, and mineral metabolism. RESULTS: VCs were observed in 50 patients (42%) before renal transplantation. Patients with VCs were older, but no statistical differences were found in the pre-transplant study between sex, diabetes, body mass index, and cardiovascular events. We found a major patient survival (limited to first 2 years after transplantation), graft survival, and death-censored graft survival in those without VCs (P = .037, P = .015, and P = .023, respectively). In line with results, a higher incidence of major cardiovascular events (MACE) and cardiovascular death was observed in the group with preexisting calcification (P = .016/P = .019). In the multivariable analysis, VCs were not an independent predictor for graft loss, death-censored graft loss, or major cardiovascular events. CONCLUSIONS: Simple evaluation of VCs with the use of the KI at the time of transplantation relates with graft and patient survival and with MACE after renal transplantation.


Subject(s)
Aorta, Abdominal/diagnostic imaging , Cardiovascular Diseases/epidemiology , Diabetes Mellitus/epidemiology , Graft Survival , Kidney Failure, Chronic/surgery , Kidney Transplantation , Vascular Calcification/epidemiology , Aged , Comorbidity , Female , Humans , Hypertension/epidemiology , Incidence , Kidney Failure, Chronic/epidemiology , Male , Middle Aged , Mortality , Prognosis , Proportional Hazards Models , Radiography , Renal Dialysis , Retrospective Studies , Risk Factors , Transplant Recipients , Vascular Calcification/diagnostic imaging
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