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J Med Microbiol ; 67(8): 1078-1082, 2018 Aug.
Article in English | MEDLINE | ID: mdl-29972349

ABSTRACT

We investigated the incidence of and risk factors for liver involvement (LI) in patients with brucellosis in Turkey. Diagnosis was established by blood cultures (BCs) or compatible clinical presentation accompanied by serological evidence. Patients received either a combination of doxycycline plus rifampin for 6 weeks or doxycycline for 6 weeks plus streptomycin intramuscularly for the first 2 weeks. Liver function tests, including those for alanine (ALT) and aspartate aminotransferase (AST) levels, were monitored before and at the end of treatment. One hundred and ninety-five patients were included in the study. Seventy patients had elevated transaminases before treatment. Twenty-six patients had a positive BC for brucellosis. In multivariate analysis, BC positivity (OR=2.44, 95 % CI: 1.03-5.78, P=0.043) and serum agglutination titre (SAT) (OR=1.001, 95 % CI: 1.00-1.002, P=0.018) were found to be associated with LI. Serum aminotransferase levels were normalized in all patients with brucellosis. BC positivity and high SAT are independent factors that are associated with LI in patients with brucellosis.


Subject(s)
Blood/microbiology , Brucellosis/pathology , Liver Diseases/epidemiology , Liver Diseases/pathology , Adult , Alanine Transaminase/blood , Anti-Bacterial Agents/administration & dosage , Aspartate Aminotransferases/blood , Blood Culture , Brucellosis/drug therapy , Female , Hemagglutination Tests , Humans , Incidence , Injections, Intramuscular , Liver Function Tests , Male , Middle Aged , Prospective Studies , Turkey/epidemiology
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