ABSTRACT
BACKGROUND: The aim of this study was to investigate the role of gene variations of Toll-like receptors (TLR) 2, 3, and 4 on genetic susceptibility to periapical pathosis. MATERIAL AND METHODS: One hundred patients were included in the study and divided into two groups as follows; Control Group (n=50) that have root canal treatment and no periapical lesion, Patient Group (n=50) that have root canal treatment and periapical lesion. TLR2 Arg753Gln, TLR3 (c.1377C/T) and TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped by using PCR-RFLP. Genotypical analysis of control and patient groups were investigated to disclose whether there is any association between periapical lesions and gene variations. RESULTS: There are no significant statistical differences between control and patient groups according to TLR 2 and 4 gene sequence. On the contrary, CC allele detected 74% for TLR 3 in patient group, and this difference was found to be statistically significant (p < 0.005). CONCLUSIONS: According to these results, it can be suggested that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis.
Subject(s)
Genetic Predisposition to Disease , Periapical Diseases/genetics , Toll-Like Receptor 2/genetics , Toll-Like Receptor 3/genetics , Toll-Like Receptor 4/genetics , Alleles , Case-Control Studies , Humans , Polymorphism, Genetic , Polymorphism, Single Nucleotide , Toll-Like ReceptorsABSTRACT
OBJECTIVE: To investigate the frequency and characteristics of the mandibular accessory buccal foramen (ABF) with CT. METHODS: A retrospective study was carried out using the CT records of 504 patients referred to the Erciyes University Medical School (Kayseri, Turkey) between 2007 and 2010. Presence, location, diameter, area and number of ABFs and their continuity with mandibular canal and distance to the mental foramen were evaluated using axial, sagittal and three-dimensional CT images. Statistical analysis was performed using SPSS® v. 15 (SPSS Inc., Chicago, IL), and t-tests were used for statistical analysis. RESULTS: 14 ABFs were observed in 10 (2%) of 504 patients. The frequency of ABFs was found to be 2.6% in males and 1% in females. The mean distance between the ABF and the mental foramen was 5.0 mm [standard deviation (SD) ± 2.48]. The mean long axis of the ABFs was 1.4 mm (SD ± 0.4) and the mean area of them was 1.5 mm(2) (SD ± 0.8). The mean area of the mental foramen on the side with the ABF was 4.1 mm(2) (SD ± 2.71). CONCLUSIONS: This study presents a relatively lower frequency of ABFs than that in the literature. These foramina could have more complex neurovascular structures than was previously thought. Thus, in special cases where a direct surgical exploration during the planned surgery is not indicated, CT or cone beam CT examination to determine the possible presence of ABFs may be indicated.
Subject(s)
Mandible/diagnostic imaging , Tomography, X-Ray Computed/methods , Adult , Algorithms , Cephalometry/methods , Cone-Beam Computed Tomography/methods , Female , Humans , Imaging, Three-Dimensional/methods , Male , Mandible/anatomy & histology , Retrospective StudiesABSTRACT
Stafne bone defects (SBDs) are asymptomatic lingual bone depressions of the lower jaw that are frequently caused by soft-tissue inclusion. The common variant of SBD exists at the third molar region of the mandible below the inferior dental canal is an and ovoid-shaped homogeneous well-defined radiolucency. In this report, an unusual occurrence of SBD with multilocular appearance is presented. Asymptomatic lingual bone defects may represent various radiographic features. Detailed radiographic evaluation with CT scans should be performed to differentiate SBDs from other pathologies.
Subject(s)
Jaw Cysts/diagnostic imaging , Mandibular Diseases/diagnostic imaging , Adipose Tissue/diagnostic imaging , Anatomy, Cross-Sectional/methods , Follow-Up Studies , Humans , Imaging, Three-Dimensional/methods , Male , Middle Aged , Radiography, Panoramic , Tomography, X-Ray Computed/methodsABSTRACT
Morphological changes such as bifid and trifid mandibular condyle are rare entities. The aim of the present report is to describe a unique morphological variation of the mandibular condyle which has four separate condylar heads (tetrafid mandibular condyle) and to discuss clinical and radiological differential diagnosis of tetrafid mandibular condyle with advanced imaging techniques.
Subject(s)
Mandibular Condyle/abnormalities , Adult , Diagnosis, Differential , Female , Humans , Imaging, Three-Dimensional , Magnetic Resonance Imaging , Radiography, Panoramic , Tomography, X-Ray ComputedABSTRACT
Stafne bone defects (SBDs) are asymptomatic lingual bone depressions of the lower jaw that are frequently caused by soft tissue inclusion. The common variant of SBDs exists at the third molar region of the mandible below the inferior dental canal and has been mostly diagnosed incidentally during routine radiographic examination. The anterior variant of a SBD (ASBD) is relatively uncommon and is located in the premolar region of the mandible. Sublingual salivary glands are thought to be responsible for ASBDs. However, other structures such as lymphoid or vascular tissues might be associated with ASBDs. In the present report, an ASBD which was mimicking a residual cyst was diagnosed with the aid of a three-dimensional CT scan. ASBDs might be confused with other odontogenic or non-odontogenic pathologies because of their location and lower occurrence rate. Advanced imaging modalities, especially CT scans, are useful to assess such lesions in order to avoid unnecessary surgery.
