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Bioorg Med Chem ; 16(9): 4759-800, 2008 May 01.
Article in English | MEDLINE | ID: mdl-18378462

ABSTRACT

Hypertension is one of the most serious health problems of the modern world with a continuous rise in the number of patients. Selective alpha(1)-adrenoreceptor antagonists though have many advantages and uses in the management of arterial hypertension, their lack of specificity at the level of alpha(1)-adr subtypes leads to multiple side effects. Existence of multiple alpha(1)-adr subtypes holds great promise for the discovery and development of more specific and selective drug molecules, targeting only one alpha(1)-adr subtype at a time and thus relative freedom from side effects. Herein, the research done on the discovery and evaluation of a variety of chemically diverse structures as selective antagonists of alpha(1)-adr and alpha(1)-adr subtypes in recent years has been reviewed.


Subject(s)
Adrenergic alpha-1 Receptor Antagonists , Adrenergic alpha-Antagonists/therapeutic use , Antihypertensive Agents/therapeutic use , Hypertension/drug therapy , Adrenergic alpha-Antagonists/chemistry , Adrenergic alpha-Antagonists/pharmacology , Animals , Antihypertensive Agents/chemistry , Antihypertensive Agents/pharmacology , Humans , Molecular Structure , Receptors, Adrenergic, alpha-1/classification , Risk Factors , Stereoisomerism , Structure-Activity Relationship
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