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1.
Clin Nucl Med ; 43(9): 679-681, 2018 Sep.
Article in English | MEDLINE | ID: mdl-30036258

ABSTRACT

Ga-prostate-specific membrane antigen (PSMA) ligand PET/CT is commonly believed to be prostate specific as the name itself suggests. However, PSMA-expressing nonprostatic cancers as well as benign lesions are continuously being added to the list. We reported PSMA-expressing Schmorl's node in L1 vertebra of a 74-year-old man with prostate cancer. Prostate-specific membrane antigen expression in the vertebral lesion raised a metastatic suspicion. However, on analysis of previous CT scan done 2 years before, the same lesion was observed with no significant interval change, confirming its benign nature. With more use of PSMA ligand PET/CT, more limitations and false positivities will be explored.


Subject(s)
Antigens, Surface/metabolism , Gallium Radioisotopes , Glutamate Carboxypeptidase II/metabolism , Intervertebral Disc/diagnostic imaging , Positron Emission Tomography Computed Tomography , Aged , Humans , Ligands , Male , Prostatic Neoplasms/diagnostic imaging , Prostatic Neoplasms/metabolism , Prostatic Neoplasms/pathology
3.
Indian J Nucl Med ; 32(1): 75-76, 2017.
Article in English | MEDLINE | ID: mdl-28242997

ABSTRACT

Pleuroperitoneal mesothelioma is an extremely rare entity. Only few cases are reported worldwide. We hereby represent a case of pleural mesothelioma referred for F-18-Fluorodeoxyglucose positron emission tomography/computed tomography for response evaluation. Diffuse F-18-Fluorodeoxyglucose avid peritoneal and omental thickening noted which subsequently turned out to be mesothelial involvement on peritoneal biopsy. This case demonstrates the role of F-18-Fluorodeoxyglucose positron emission tomography/computed tomography in detecting other sites of involvement in case of malignant mesothelioma.

4.
Clin Nucl Med ; 42(2): 123-124, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27997430

ABSTRACT

Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, and it contributes approximately 90% of all oral malignancies. We present a case of a squamous cell carcinoma of the tongue with rare site of bilateral adrenal metastases on F-FDG PET/CT with response evaluation after chemotherapy.


Subject(s)
Adrenal Gland Neoplasms/secondary , Carcinoma, Squamous Cell/diagnostic imaging , Positron Emission Tomography Computed Tomography , Tongue Neoplasms/diagnostic imaging , Adrenal Gland Neoplasms/diagnostic imaging , Aged , Carcinoma, Squamous Cell/pathology , Fluorodeoxyglucose F18 , Humans , Male , Middle Aged , Radiopharmaceuticals , Tongue Neoplasms/pathology
5.
Nucl Med Mol Imaging ; 50(4): 344-347, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27994690

ABSTRACT

68Ga-Prostate specific membrane antigen- N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncertain at this time. Clinical studies are underway to define its exact role in the management of the disease. At the same time it is important to be aware of unexpected sites of uptake of this ligand. We present here the case of a 62-year-old male patient who underwent prostatectomy for adenocarcinoma prostate. He also had a long-standing left solitary thyroid nodule (STN). Four months after surgery, he had a rising trend in serum PSA levels on three occasions, but the absolute value was less than 4 at all times. He underwent a 68Ga-PSMA-HBED-CC PET/CT, but it did not reveal any recurrent/metastatic site of disease. However, there was increased tracer uptake in the left STN. Fine needle aspiration cytology revealed features of atypia of undetermined significance, Bethesda category III. The patient underwent a left hemithyroidectomy and the histopathology showed features of a follicular adenoma.

6.
Indian J Nucl Med ; 31(4): 292-294, 2016.
Article in English | MEDLINE | ID: mdl-27833317

ABSTRACT

Paraneoplastic neurological syndromes (PNSs) are commonly encountered with underlying malignant pathology. Though anti--neuronal antibodies play a major role in the diagnosis of the underlying malignant pathology but at many times it becomes inconclusive. As early detection of the primary cause and its treatment gives the best result in such situations, there arises an early and accurate diagnostic need. We present a 65--year--old patient presenting with rapidly progressive quadriparesis with both distal and proximal involvement. With all routine work--up tests within normal limits, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) was done which revealed multiple findings that suggested a diagnosis of lymphoma. In our case, PET/CT proved to be an important modality for finding the underlying malignant pathology in a suspected case of PNS.

7.
9.
Indian Dermatol Online J ; 7(2): 125-6, 2016.
Article in English | MEDLINE | ID: mdl-27057499
12.
Indian J Nucl Med ; 31(1): 83-4, 2016.
Article in English | MEDLINE | ID: mdl-26917909

ABSTRACT

The present case highlights the importance of history taking in solving the dilemmas of variant F-18 FDG uptake on PET/CT. Asymmetrically increased, abnormal looking, FDG uptake in the right breast of our patient was related to her breast feeding practice. Because of personal preference the patient suckled her child from the right breast only. This resulted in asymmetry of size, increase in glandular breast parenchyma and FDG uptake in the breast that was suckled.

13.
Clin Nucl Med ; 41(5): 419-20, 2016 May.
Article in English | MEDLINE | ID: mdl-26859207

ABSTRACT

Epilepsy is one of the most common neurological conditions, which affect nearly 1% of the entire population. We present F-FDG PET-CT findings of a mammillary body epileptic focus in a 50-year-old woman with a 5-year history of seizure and behavior disturbance and memory problems for the past 4 years.


Subject(s)
Epilepsy/diagnostic imaging , Fluorodeoxyglucose F18 , Mammillary Bodies/pathology , Positron-Emission Tomography/methods , Tomography, X-Ray Computed/methods , Female , Humans , Middle Aged , Radiopharmaceuticals , Seizures/diagnostic imaging
14.
Malays J Pathol ; 37(2): 159-63, 2015 Aug.
Article in English | MEDLINE | ID: mdl-26277675

ABSTRACT

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a common lymphoproliferative disorder with an increased risk of developing subsequent neoplasms of epithelial and mesenchymal origin. The decreased immunity and B-cell dysfunction in CLL probably accounts for this emergence of second malignancies. We report a case of synchronous bladder transitional cell carcinoma (TCC) and prostatic carcinoma with CLL. A 74-year-old male who underwent transurethral resection of the prostate (TURP) for benign prostatic hyperplasia 2 years before, presented with recurrent urinary tract infection. Peripheral blood smear revealed leukocytosis with absolute lymphocytosis (absolute lymphocyte count: 37870 cells/mm³). Flow cytometric immunophenotyping revealed 75% abnormal lymphoid cells which were positive for CD 19, CD5, CD23, CD22, CD200, CD20 (moderate) with lambda light chain restriction and negative for CD3, CD10, FMC7, CD38, CD138, IgM, CD103, CD123. F Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) showed increased metabolic activity of the left lateral wall of the urinary bladder extending to the left UV junction, adjacent part of trigone and bladder neck region along with multiple heterogeneous enhancing areas with increased FDG avidity within the prostate. Transurethral resection of the bladder tumour by cystoscopy was performed. Histopathology showed high grade, muscle invasive urothelial carcinoma. Due to presence of uptake in the prostate, transurethral resection of the prostate was done and histopathology revealed adenocarcinoma of prostate (prostate specific antigen- positive), Gleason grade III+III and Gleason score 6. A high index of suspicion is required to detect synchronous and metachronous malignancies. Ancillary studies such as immunohistochemistry, flow cytometry and PET/CT are often essential for detection and an accurate diagnosis.


Subject(s)
Adenocarcinoma/pathology , Carcinoma, Transitional Cell/pathology , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Neoplasms, Multiple Primary/pathology , Prostatic Neoplasms/pathology , Urinary Bladder Neoplasms/pathology , Aged , Flow Cytometry , Humans , Immunophenotyping , Male , Multimodal Imaging , Positron-Emission Tomography , Tomography, X-Ray Computed
15.
Biomed Res Int ; 2014: 172646, 2014.
Article in English | MEDLINE | ID: mdl-24987670

ABSTRACT

PURPOSE OF THE REPORT: There is a paucity of data on correlation of various imaging modalities with clinical findings in craniosynostosis. Moreover, no study has specifically reported the role of (99m)Tc-ECD SPECT in a large number of subjects with craniosynostosis. MATERIALS AND METHODS: We prospectively analyzed a cohort of 85 patients with craniosynostosis from year 2007 to 2012. All patients underwent evaluation with (99m)Tc-ECD SPECT and the results were correlated with radiological and surgical findings. RESULTS: (99m)Tc-ECD SPECT revealed regional perfusion abnormalities in the cerebral hemisphere corresponding to the fused sutures preoperatively that disappeared postoperatively in all the cases. Corresponding to this, the mean mental performance quotient (MPQ) increased significantly (P < 0.05) postoperatively only in those children with absent perfusion defect postoperatively. CONCLUSIONS: Our study suggests that early surgery and release of craniosynostosis in patients with preoperative perfusion defects (absent on (99m)Tc-ECD SPECT study) are beneficial, as they lead to improved MPQ after surgery.


Subject(s)
Craniosynostoses/diagnostic imaging , Craniosynostoses/surgery , Cysteine/analogs & derivatives , Organotechnetium Compounds/administration & dosage , Radiopharmaceuticals/administration & dosage , Tomography, Emission-Computed, Single-Photon/methods , Child, Preschool , Cysteine/administration & dosage , Female , Humans , Infant , Male , Radiography , Retrospective Studies
16.
Clin Nucl Med ; 39(1): 77-8, 2014 Jan.
Article in English | MEDLINE | ID: mdl-23531730

ABSTRACT

Dermatofibrosarcoma protuberans is a rare cutaneous tumor that is locally aggressive and has a high rate of recurrence after surgical excision. The tumor grows slowly, typically over years. On rare occasions, metastasis to distant sites (especially the lung) or regional lymph nodes may occur. Here, we present F-FDG PET/CT imaging findings of a 52-year-old man with a local recurrence of dermatofibrosarcoma protuberans in the anterior abdominal wall with metastases to bilateral lungs.


Subject(s)
Dermatofibrosarcoma/pathology , Fluorodeoxyglucose F18 , Lung Neoplasms/secondary , Multimodal Imaging , Positron-Emission Tomography , Tomography, X-Ray Computed , Humans , Male , Middle Aged , Recurrence
18.
Clin Nucl Med ; 39(2): 184-5, 2014 Feb.
Article in English | MEDLINE | ID: mdl-23856827

ABSTRACT

Adrenal metastases have commonly been reported in a wide variety of cancers but not in gallbladder cancer. We here present a case of a 45-year-old male patient with gallbladder carcinoma where left adrenal metastasis was detected on staging F-FDG PET/CT. This was confirmed histopathologically. F-FDG PET/CT can have a significant impact on management of patients with gallbladder carcinoma by demonstrating rare sites of metastasis.


Subject(s)
Adrenal Gland Neoplasms/diagnosis , Adrenal Gland Neoplasms/secondary , Fluorodeoxyglucose F18 , Gallbladder Neoplasms/pathology , Multimodal Imaging , Positron-Emission Tomography , Tomography, X-Ray Computed , Gallbladder Neoplasms/diagnostic imaging , Humans , Male , Middle Aged
19.
Clin Nucl Med ; 38(11): e433-4, 2013 Nov.
Article in English | MEDLINE | ID: mdl-24096996

ABSTRACT

Gallbladder carcinoma is characterized by poor prognosis. It spreads by direct, lymphatic, vascular, neural, intraperitoneal, and intraductal routes. The most commonly involved organ is the liver followed by regional lymph nodes. Extra-abdominal metastases are comparatively rare. We present a case of solitary breast metastasis from recurrent gallbladder carcinoma mimicking a primary breast cancer in (18)F-FDG PET/CT.


Subject(s)
Breast Neoplasms/diagnostic imaging , Breast Neoplasms/secondary , Fluorodeoxyglucose F18 , Gallbladder Neoplasms/pathology , Neoplasms, Second Primary/diagnostic imaging , Positron-Emission Tomography , Tomography, X-Ray Computed , Adult , Breast Neoplasms/pathology , Diagnosis, Differential , Female , Gallbladder Neoplasms/diagnostic imaging , Humans , Neoplasms, Second Primary/pathology
20.
Jpn J Radiol ; 31(11): 766-9, 2013 Nov.
Article in English | MEDLINE | ID: mdl-24085587

ABSTRACT

Pulmonary alveolar microlithiasis (PAM) is a very rare disease in which multiple microscopic calcium phosphate microliths are deposited within the alveoli of both lungs. A lung biopsy is considered to be definitive for final diagnosis; however, non-invasive imaging modalities such as chest X-ray, HRCT scan and (99m)Tc-MDP bone scan suggest the diagnosis in the vast majority of patients. Although (18)F-FDG PET/CT has been tried to characterize the disease, (18)F-sodium fluoride PET/CT as a 'proof-of-principle' was tried for the first time in a known case of PAM in order to characterize the lung lesions. Interestingly, we noted that (18)F-sodium fluoride PET/CT is a superior modality in characterization and assessment of the extent of disease in PAM compared to all other non-invasive imaging modalities. Thus, we recommend that (18)F-sodium fluoride PET/CT should be the investigation of choice in PAM.


Subject(s)
Calcinosis/diagnosis , Fluorine Radioisotopes , Fluorodeoxyglucose F18 , Genetic Diseases, Inborn/diagnosis , Lung Diseases/diagnosis , Positron-Emission Tomography , Radiopharmaceuticals , Sodium Fluoride , Tomography, Emission-Computed, Single-Photon , Tomography, X-Ray Computed , Calcinosis/diagnostic imaging , Genetic Diseases, Inborn/diagnostic imaging , Humans , Lung Diseases/diagnostic imaging , Male , Middle Aged , Positron-Emission Tomography/methods , Predictive Value of Tests , Rare Diseases , Sensitivity and Specificity , Tomography, Emission-Computed, Single-Photon/methods , Tomography, X-Ray Computed/methods
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