Frequency drift characterization of a laser stabilized to an optical fiber delay line.

Lasers stabilized to optical fiber delay lines have been shown to deliver a comparable short-term (<1 s) frequency noise performance to that achieved by lasers stabilized to ultra-low expansion (ULE) cavities, once the linear frequency drift has been removed. However, for continuous stable laser operations, the drift can be removed only when it can be predicted, e.g., when it is linear over very long timescales. To date, such long-term behaviour of the frequency drift in fiber delay lines has not been, to the best of our knowledge, characterised. In this work we experimentally characterise the frequency drift of a laser stabilised to a 500 m-long optical fiber delay line over the course of several days. We show that the drift still follows the temperature variations even when the spool temperature is maintained constant with fluctuations below tens of mK. Consequently, the drift is not linear over long timescales, preventing a simple feed-forward compensation. However, here we show that the drift can be reduced by exploiting the high level of correlation between laser frequency and the fiber temperature. In our demonstration, by applying a frequency correction proportional to temperature readings, a calculated frequency drift of less than 16 Hz/s over the several days of our test was obtained, corresponding to a 23-fold improvement from uncorrected values.

Coherent O-band WDM transmission of DP-16QAM over a 50-km BDFA-amplified link.

We present wavelength-division multiplexed coherent transmission in an O-band amplified link enabled by bismuth-doped fiber amplifiers (BDFAs). Transmission of 4 × 25 GBd DP-16QAM (4 × 200 Gb/s) is demonstrated over a single span of 50-km length, occupying a bandwidth of 4.7 THz across the wavelengths 1323 nm to 1351 nm.

High-gain ultra-wideband bismuth-doped fiber amplifier operating in the O + E + S band.

We present a double-pass bismuth (Bi)-doped fiber amplifier (BDFA) providing high-gain wideband amplification from 1330 to 1480 nm. A peak gain of 38 dB with 4.7 dB noise figure (NF) was obtained at 1420 nm for a -23 dBm input signal, with >20 dB gain from 1335 to 1475 nm. We achieved 30  and 21.5 dB peak gains with 122 nm (1341-1463 nm) and 140 nm (1333-1473 nm) 6 dB-gain bandwidth for -10 and 0 dBm input signal, respectively. For a 0 dBm signal, the power conversion efficiency (PCE) reached 23.7%, and the in-band optical-signal-to-noise ratio (OSNR) across the wideband BDFA was >44 dB. Also, the absorption and luminescence characteristics have been studied for different Bi-doped phosphosilicate fibers (BPSFs) fabricated in-house.

Efficacy of baricitinib for the treatment of systemic lupus erythematosus patients: A meta-analysis of randomized controlled trials.

BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by abnormal autoantibody production, inflammation, and organ damage. Most SLE treatment strategies aim to induce remission or reduce disease activity while avoiding flares. Baricitinib has been used effectively to manage various inflammatory diseases, and some randomized controlled trials (RCT) have shown that it is beneficial in treating SLE. The current study aims to assess the efficacy of baricitinib in treating SLE patients. MATERIALS AND METHODS: Various databases such as PubMed, Scopus, and Science Direct were searched to obtain eligible studies for the present meta-analysis. Data such as baseline characteristics of patients, doses of the baricitinib, follow-up duration, and treatment outcome in the form of SLE responder index-4 (SRI-4) and lupus low disease activity state (LLDAS) were extracted. Combined odds ratio, 95% confidence interval, and probability values were calculated to study the efficacy of baricitinib in treating SLE patients. A p-value less than .05 was taken as significant. Comprehensive meta-analysis v3 was used for all analyses. RESULTS: Three articles were found eligible for the present meta-analysis comprising 614 patients with placebo, 614 SLE patients receiving 4 mg, and 621 patients with 2 mg of baricitinib. Meta-analysis revealed a beneficial effect of 4 mg baricitinib in SLE patients compared to placebo, as measured by an increase in the SRI-4 (p = .006, OR = 1.370) and LLDAS (p = .083, OR = 1.252) rates. In contrast to the placebo group, however, patients receiving 2 mg of baricitinib exhibited no significant improvement. The trial sequential analysis revealed the need for additional RCTs to determine the role of baricitinib in treating SLE patients. CONCLUSION: In treating SLE patients, administrating a higher dose of baricitinib (4 mg) may be effective. However, additional RCTs in different populations with larger sample sizes are required to validate our findings.

Radiation-resistant cerium co-doped erbium-doped fibers for C- and L-band amplifiers in a high-dose gamma-radiation environment.

We experimentally demonstrate a comparative study on the radiation-resistant cerium (Ce) co-doped erbium-doped fiber amplifiers (EDFAs) exposed to a high-dose gamma-radiation environment of 1.8 kGy/h dose rate in the C and L bands. Our results show that Ce is an effective co-dopant in the aluminosilicate EDFs for suppressing radiation-induced attenuation (RIA) of more than an order of magnitude lower than the Ce-free EDF. After exposure to a high-dose gamma-radiation of up to 10 kGy, the Ce co-doped EDF still exhibits good radiation tolerance, providing 41.6 ± 2.9 dB gain and 5 ± 0.8 dB NF from 1535-1560 nm for a -25 dBm input signal. In the L-band, we report, for the first time, the radiation-resistant EDFA with the radiation-induced gain degradation (RIGD) of 3.7 dB under 2.5 kGy irradiation and 4.4 dB under 10 kGy irradiation at 1600 nm. Also, the radiation-dependent gain coefficient and gain saturation were studied in the C and L bands. A comparison of different Ce co-doped EDFs exposed to different total gamma doses reveals the radiation impact on the amplifier performance, indicating the feasibility of using Ce co-doped EDFs for space-based optical communications, requiring robust radiation stability.

Flat-gain L-band amplifier containing AlPO4 units in aluminophosphosilicate erbium-doped fibers.

We present a flat-gain single-stage L-band erbium-doped fiber amplifier (EDFA) with a gain ripple of ±0.7 dB from 1580 to 1615 nm, by using aluminophosphosilicate erbium-doped fiber (APS-EDF) with an estimated AlPO4 composition of 13.3 mol%. A series of APS-EDFs were fabricated with increasing AlPO4 and Er concentrations, while maintaining a low background loss of 0.031 ± 0.005 dB/m and preventing Er ion clustering. The spectroscopic study shows a slightly narrowing Er cross section and flattened emission cross-section spectrum in the L-band with more AlPO4, thus favoring the L-band amplification with an improved gain flatness. Also, the gain coefficient, gain saturation, and temperature-dependent gain characteristics were reported. A better temperature tolerance was observed with increasing AlPO4.

Bi-doped fiber amplifiers in the E + S band with a high gain per unit length.

We present a bismuth (Bi)-doped fiber amplifier (BDFA) operating in the 1400-1480 nm range using 35 m of Bi-doped germanosilicate fiber. A maximum gain of 23 dB for an input signal of -23dBm at 1440 nm has been achieved, which, to the best of our knowledge, is the highest gain per unit length of 0.66 dB/m reported for a BDFA. The 3 dB bandwidth is measured to be 40 nm (1415-1455 nm), and the gain coefficient is 0.2 dB/mW. A further temperature dependence study of BDFA across the temperature range of -60°C to 80°C also showed a negligible effect of temperature on the E + S band BDFA gain.

Mode attraction, rejection and control in nonlinear multimode optics.

Novel fundamental notions helping in the interpretation of the complex dynamics of nonlinear systems are essential to our understanding and ability to exploit them. In this work we predict and demonstrate experimentally a fundamental property of Kerr-nonlinear media, which we name mode rejection and takes place when two intense counter-propagating beams interact in a multimode waveguide. In stark contrast to mode attraction phenomena, mode rejection leads to the selective suppression of a spatial mode in the forward beam, which is controlled via the counter-propagating backward beam. Starting from this observation we generalise the ideas of attraction and rejection in nonlinear multimode systems of arbitrary dimension, which paves the way towards a more general idea of all-optical mode control. These ideas represent universal tools to explore novel dynamics and applications in a variety of optical and non-optical nonlinear systems. Coherent beam combination in polarisation-maintaining multicore fibres is demonstrated as example.

Experimental investigation of BDFA-based O-band direct-detection transmission using an optical recirculating loop.

We implemented a bismuth-doped fiber amplifier (BDFA) based optical recirculating loop to investigate the performance of amplified O-band transmission over appreciable distances. Both single-wavelength and wavelength-division multiplexed (WDM) transmission were studied, with a variety of direct-detection modulation formats. We report on (a) transmission over lengths of up to 550 km in a single-channel 50-Gb/s system operating at wavelengths ranging from 1325 nm to 1350 nm, and (b) rate-reach products up to 57.6 Tb/s-km (after accounting for the forward error correction redundancy) in a 3-channel system.

Tunable dissipative soliton Tm-doped fiber laser operating from 1700 nm to 1900 nm.

In this Letter, we demonstrate an ultrabroadband (1700-1900 nm) tunable Tm-doped fiber laser (TDFL) generating dissipative solitons in the net-normal dispersion regime. The laser delivers pulses with spectral widths ranging from 10 nm to 23 nm and pulse durations from 8.7 ps to 18.3 ps. Stretched-free pulse amplification at the gain edge (1708 nm) and gain peak (1807 nm) is implemented to demonstrate the range of further power scalability of the laser signal. The maximum achieved power in a one-stage Tm-doped amplifier is 140 mW with a compressed pulse duration of 478 fs. Considering the diverse utility of this wavelength band, this laser is highly desirable for applications such as optical sensing, biological imaging, and industrial machining.

Experimental demonstration of single-span 100-km O-band 4×50-Gb/s CWDM direct-detection transmission.

We report on what is to the best of our knowledge the longest 50-Gb/s/λ O-band wavelength-division multiplexed (WDM) transmission. A pair of in-house built bismuth-doped fiber amplifiers (BDFAs) and the use of Kramers-Kronig detection-assisted single-sideband transmission are adopted to overcome the fiber loss and chromatic dispersion, respectively, in a reach-extended O-band coarse WDM (CWDM) system with a channel spacing of ∼10 nm. Through experiments on an amplified 4×50-Gb/s/λ direct-detection system based on booster and pre-amp BDFAs, we show the superior performance of single-sideband transmission in terms of both optical signal-to-noise ratio sensitivity and uniformity in performance amongst CWDM channels relative to double-sideband transmission after both 75-km and 100-km lengths of single-mode fiber. As a result, up to 100-km reach with comparable performance at all 50-Gb/s channels was achieved without the need for in-line optical amplification.

Numerical and experimental study on the impact of chromatic dispersion on O-band direct-detection transmission.

The recent emergence of efficient O-band amplification technologies has enabled the consideration of O-band transmission beyond short reach. Despite the O-band being a low chromatic dispersion (CD) window, the impact of CD will become increasingly significant when extending the reach of direct-detection (DD) systems. In this work, we first numerically investigate the 3-dB bandwidth of single-mode fibers (SMF) and the CD-restricted transmission reach in intensity-modulation DD systems, confirming the significant difference between low- and high-dispersion O-band wavelengths. We then carry out experimental transmission studies over SMF for distances of up to 70 km at two different wavelengths, the low-dispersion 1320 nm and the more dispersive 1360 nm, enabled by the use of an O-band bismuth-doped fiber amplifier as a preamplifier at the receiver. We compare three 50-Gb/s optical DD formats, namely, Nyquist on-off keying (OOK), Nyquist 4-ary pulse amplitude modulation (PAM4) and Kramers-Kronig detection-assisted single-sideband quadrature phase shift keying (KK-QPSK) half-cycle subcarrier modulation. Our results show that at both wavelengths, OOK and QPSK exhibit better bit error rate performance than PAM4. When transmitting over 70-km of SMF at the less dispersive wavelength of 1320 nm, 50-Gb/s OOK modulation offers more than 1.5-dB optical power sensitivity improvement at the photodiode (PD) compared to 50-Gb/s QPSK. Conversely, at 1360 nm, the required optical power to the PD can be reduced by more than 3 dB by using QPSK instead of OOK.

Experimental characterization of an o-band bismuth-doped fiber amplifier.

The recent emergence of bismuth-doped fiber amplifiers (BDFAs) offers the potential to transmit high-speed WDM signals over long distances in the O-band spectral region, thereby greatly enhancing the scope of systems utilizing these wavelengths. In this paper, we present a comprehensive experimental study on several basic characteristics of an O-band BDFA based on a phosphosilicate optical fiber, including the frequency-dependent noise figure, gain tilt (static and dynamic), transient response, and polarization dependent gain. We discuss our findings and their implications on the use of BDFA technology in high bit-rate multichannel systems.

Enhancement of nonlinear functionality of step-index silica fibers combining thermal poling and 2D materials deposition.

This work proposes a new route to overcome the limits of the thermal poling technique for the creation of second order nonlinearity in conventional silica optical fibers. We prove that it is possible to enhance the nonlinear behavior of periodically poled fibers merging the effects of poling with the nonlinear intrinsic properties of some materials, such as MoS2, which are deposited inside the cladding holes of a twin-hole silica fiber. The optical waves involved in a second harmonic generation process partially overlap inside the thin film of the nonlinear material and exploit its higher third order susceptibility to produce an enhanced SHG.

Nested-ring doping for highly efficient 1907 nm short-wavelength cladding-pumped thulium fiber lasers.

Cladding-pumped Tm-doped fiber lasers operating below 1950 nm have difficulty matching the high-efficiency, power-scalable output that can be achieved at longer wavelengths. This challenge arises due to the strong three-level behavior at short wavelengths and strong competition from higher-gain long wavelength emission. In this Letter, we demonstrate a nested-ring fiber design in which a highly doped Tm ring is embedded within a larger undoped core. The fiber is specifically tailored for highly efficient and high power short-wavelength operation (<1950nm). The nested-ring Tm fiber laser has generated 62 W of single-mode 1907 nm output with up to 65% (70%) slope efficiency with respect to launched (absorbed) pump power.

Thulium fiber laser: The new kid on the block.

OBJECTIVE: Laser technology in urology is currently used for both stone lithotripsy and prostate enucleation. Thulium fiber laser (TFL) is a novel laser, with initial studies showing potential benefits over other lasers both in terms of its effectiveness and safety profile. MATERIAL AND METHODS: In the first part of this review, a descriptive analysis of the theoretical concepts behind TFL was performed. This part focused on the physics and laser parameters as applied to the clinical practice. These were interpreted in the context of other lasers, namely, the Holmium:YAG laser to highlight the theoretical advantages as well as potential pitfalls offered by the TFL. In the second part of the review, a narrative synthesis of in-vitro studies regarding TFL and its modifications is performed assessing stone-related parameters, namely, ablation rate, operative time retropulsion, and safety. RESULTS: TFL achieved high ablation rates in most studies and performed better than Holmium:YAG laser across a range of different settings and ablation modes when the two lasers were compared. Moreover, its ability to use low pulse energy ensures minimal stone retropulsion with the retropulsion threshold estimated to be 2-4 times higher than that of Holmium:YAG laser. From a safety viewpoint, TFL poses no additional risks than other lasers, although it does potentially lead to slightly higher temperatures in the surrounding tissues during lithotripsy. CONCLUSION: The unique properties of TFL have made it an attractive alternative to conventional laser techniques currently used in urology. Clinical studies are required before its application can become more widespread.

Single is better than double: theoretical and experimental comparison between two thermal poling configurations of optical fibers.

Thermal poling, a technique to create permanently effective second-order susceptibility in silica optical fibers, has a suite of applications including frequency conversion and mixing for high harmonic generation and phase sensitive amplification, optical switching and modulation, and polarization-entangled photon pair generation. In this work, we compare both theoretically and experimentally two different electrode configurations for poling optical fibers, namely double-anode and single-anode, for two different geometries of the cladding holes. This analysis reveals that the single-anode configuration is optimal, both for the absolute value of effective χ (2) created in the fiber core, and for the simplification of the fiber fabrication process.

47 W continuous-wave 1726 nm thulium fiber laser core-pumped by an erbium fiber laser.

The high-power, short-wavelength operation of a thulium-doped silica fiber laser at 1726 nm has been demonstrated in a core-pumped monolithic (all-fiber) resonator configuration, in-band pumped by a high-power erbium-only fiber laser operating at 1580 nm. The thulium fiber laser yielded 47 W in a single-spatial-mode output beam for 60-W absorbed pump power. The corresponding slope efficiency, with respect to an absorbed pump power of 80%, compares favorably with the theoretical maximum (Stokes) efficiency of 91.5%. The prospects for further scaling of single-mode power in this wavelength regime to >100 W are considered, as well as the potential applications for high-power lasers operating in this difficult-to-reach wavelength band.

Tunable holmium-doped fiber laser with multiwatt operation from 2025 nm to 2200 nm.

The emission band of holmium-doped silica fibers extends beyond 2200 nm, which means these lasers have the potential of covering considerable parts of the atmospheric transmission window between ∼2100 nm and 2250 nm. However, efficient operation toward 2200 nm is challenging due to absorption in fused silica at the laser wavelength. Here we present a holmium-doped fiber laser specifically targeting long-wavelength operation. The laser is implemented as a high-feedback wavelength selective ring cavity and is tunable from 2025 nm to 2200 nm. A maximum slope efficiency of 58% is obtained at 2050 nm and a slope of 27% is obtained at 2200 nm. A power of 5.5 W from a single aperture (8.9 W total) is demonstrated at 2200 nm. Our results represent extended coverage of the 2 µm spectral band with multiwatt-level silica fiber lasers.

656 W Er-doped, Yb-free large-core fiber laser.

A continuous-wave erbium-doped ytterbium-free fiber laser generates a record-breaking pump-power-limited output power of 656 W at ∼1601 nm when cladding pumped by 0.98 µm diode lasers. The slope efficiency was 35.6% with respect to launched pump power, and the beam quality factor (M2) was ∼10.5. This M2 value excludes a fraction ∼25% of the power that emerged from the cladding, which we attribute in part to mode coupling between the 146 µm core and 700 µm inner cladding. Whereas these parameters are adequate for in-band tandem pumping of Tm-doped fiber lasers, we predict that an output power of over 1 kW is possible through pumping with state-of-the-art 0.98 µm diode lasers, even with a smaller core that allows for improved beam quality.