ABSTRACT
This cross-sectional study evaluated the immune status of non-vaccinated healthy infants to determine if it is possible to replace both measles vaccine (at 9 months) and measles, mumps and rubella (MMR) vaccine (at 18 months) with a single dose of MMR at 12 months. Serum samples from 566 children in Alexandria, Egypt showed a significant decrease in the seropositive rate to the 3 viral diseases with increasing age, but a significant increase in the seropositive rate among infants who were ranked 1st or 2nd in their family, full-term or born to mothers with no history of hypertension during pregnancy. We recommend administration of the first dose of MMR vaccine between 9 and 12 months of age, and a booster dose of MMR vaccine at 4 years of age.
Subject(s)
Measles Vaccine , Measles-Mumps-Rubella Vaccine , Needs Assessment/organization & administration , Vaccination/methods , Age Factors , Analysis of Variance , Child, Preschool , Cross-Sectional Studies , Egypt/epidemiology , Female , Health Planning Guidelines , Humans , Immunization Schedule , Immunization, Secondary/methods , Infant , Infant, Newborn , Male , Measles/epidemiology , Measles/immunology , Measles/prevention & control , Measles Vaccine/administration & dosage , Measles Vaccine/immunology , Measles-Mumps-Rubella Vaccine/administration & dosage , Measles-Mumps-Rubella Vaccine/immunology , Mumps/epidemiology , Mumps/immunology , Mumps/prevention & control , Rubella/epidemiology , Rubella/immunology , Rubella/prevention & control , Seroepidemiologic StudiesABSTRACT
This cross-sectional study evaluated the immune status of non-vaccinated healthy infants to determine if it is possible to replace both measles vaccine [at 9 months] and measles, mumps and rubella [MMR] vaccine [at 18 months] with a single dose of MMR at 12 months. Serum samples from 566 children in Alexandria, Egypt showed a significant decrease in the seropositive rate to the 3 viral diseases with increasing age, but a significant increase in the seropositive rate among infants who were ranked 1st or 2nd in their family, full-term or born to mothers with no history of hypertension during pregnancy. We recommend administration of the first dose of MMR vaccine between 9 and 12 months of age, and a booster dose of MMR vaccine at 4 years of age
Subject(s)
Measles Vaccine , Cross-Sectional Studies , Measles-Mumps-Rubella Vaccine , Gestational AgeABSTRACT
We assessed the long-term immunity to hepatitis B among 242 Egyptian children aged 6-12 years who had received a full vaccination course in infancy, and investigated the factors associated with immunity. Only 39.4% of the children had protective (> or = 10 lU/L) hepatitis B surface antibody levels (HBsAb). This proportion decreased with age but the decrease was not statistically significant. The mean level of HBsAb decreased significantly with increasing age (P = 0.026). A significant negative correlation was found between current age and HBsAb levels (r = -0.31, P = 0.041). Age and weight-for-age were found to be significant predictors of non-protective HBsAb levels.
Subject(s)
Hepatitis B Antibodies/blood , Hepatitis B Vaccines/immunology , Vaccination , Age Factors , Body Weight , Child , Cross-Sectional Studies , Egypt , Female , Health Services Needs and Demand , Hepatitis B Surface Antigens/immunology , Humans , Immunity, Active , Immunization Schedule , Immunization, Secondary , Logistic Models , Male , Multivariate Analysis , National Health Programs , Risk Factors , Seroepidemiologic Studies , Socioeconomic Factors , Surveys and Questionnaires , Urban Health/statistics & numerical data , Vaccination/methodsABSTRACT
We assessed the long-term immunity to hepatitis B among 242 Egyptian children aged 6-12 years who had received a full vaccination course in infancy, and investigated the factors associated with immunity. Only 39.4% of the children had protective [>/= 10 IU/L] hepatitis B surface antibody levels [HBsAb]. This proportion decreased with age but the decrease was not statistically significant. The mean level of HBsAb decreased significantly with increasing age [P = 0.026]. A significant negative correlation was found between current age and HBsAb levels [r = -0.31, P = 0.041]. Age and weight-for-age were found to be significant predictors of non-protective HBsAb levels
