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1.
Int J Colorectal Dis ; 36(5): 987-998, 2021 May.
Article in English | MEDLINE | ID: mdl-33247313

ABSTRACT

PURPOSE: Advances in endoscopic technology have led to the reevaluation of self-expandable metallic stent (SEMS) placement as a bridge-to-surgery (BTS) in patients with obstructive colorectal cancer. In Japan, after inclusion of SEMS placement as a BTS in the medical insurance coverage in 2012, this procedure has been increasingly performed. However, a transanal decompression tube (TADT) placement has been used as a BTS. We aimed to retrospectively evaluate the optimal strategy for obstructive left-sided colorectal cancer (OLCRC) by comparing SEMS and TADT placement with emergency surgery. METHODS: We included 301 patients with stage II and III OLCRC from 27 institutions. The study patients were divided into Surgery group (emergency surgery, n = 103), SEMS group (BTS by SEMS, n = 113), and TADT group (BTS by TADT, n = 85). We compared the survival and perioperative outcomes of patients in the Surgery group as a standard treatment with those in the SEMS and TADT groups. RESULTS: The 3-year relapse-free survival rate in patients in the Surgery group was 74.8%, while that in patients in the SEMS group and TADT group were 69.0% (p = 0.39) and 55.3% (p = 0.006), respectively. The technical success rate was not statistically different, but the clinical success rate was significantly higher in the SEMS group than in the TADT group (p = 0.0040). With regard to postoperative complications after curative surgery, the SEMS group had significantly lower of complications (≥ grade 2) than the Surgery group (p = 0.022). CONCLUSION: Patients who underwent SEMS placement for OLCRC had similar oncological outcomes to patients who underwent emergency surgery.


Subject(s)
Colorectal Neoplasms , Intestinal Obstruction , Self Expandable Metallic Stents , Colorectal Neoplasms/complications , Colorectal Neoplasms/surgery , Decompression , Humans , Intestinal Obstruction/etiology , Intestinal Obstruction/surgery , Japan , Neoplasm Recurrence, Local , Retrospective Studies , Stents , Treatment Outcome
2.
Br J Surg ; 107(5): 586-594, 2020 04.
Article in English | MEDLINE | ID: mdl-32162301

ABSTRACT

BACKGROUND: Japan Clinical Oncology Group (JCOG) 0212 (ClinicalTrials.gov NCT00190541) was a non-inferiority phase III trial of patients with clinical stage II-III rectal cancer without lateral pelvic lymph node enlargement. The trial compared mesorectal excision (ME) with ME and lateral lymph node dissection (LLND), with a primary endpoint of recurrence-free survival (RFS). The planned primary analysis at 5 years failed to confirm the non-inferiority of ME alone compared with ME and LLND. The present study aimed to compare ME alone and ME with LLND using long-term follow-up data from JCOG0212. METHODS: Patients with clinical stage II-III rectal cancer below the peritoneal reflection and no lateral pelvic lymph node enlargement were included in this study. After surgeons confirmed R0 resection by ME, patients were randomized to receive ME alone or ME with LLND. The primary endpoint was RFS. RESULTS: A total of 701 patients from 33 institutions were assigned to ME with LLND (351) or ME alone (350) between June 2003 and August 2010. The 7-year RFS rate was 71.1 per cent for ME with LLND and 70·7 per cent for ME alone (hazard ratio (HR) 1·09, 95 per cent c.i. 0·84 to 1·42; non-inferiority P = 0·064). Subgroup analysis showed improved RFS among patients with clinical stage III disease who underwent ME with LLND compared with ME alone (HR 1·49, 1·02 to 2·17). CONCLUSION: Long-term follow-up data did not support the non-inferiority of ME alone compared with ME and LLND. ME with LLND is recommended for patients with clinical stage III disease, whereas LLND could be omitted in those with clinical stage II tumours.


ANTECEDENTES: El JCOG0212 (ClinicalTrials.gov: NCT00190541) fue un ensayo fase III de no inferioridad en pacientes con cáncer de recto en estadio clínico II/III sin ganglios linfáticos aumentados de tamaño en la pared pélvica lateral. El ensayo comparó la escisión del mesorrecto (mesorectal excision, ME) con la ME con disección de los ganglios linfáticos laterales (lateral lymph node dissection, LLND), siendo el criterio de valoración principal la supervivencia libre de recidiva (recurrence free survival, RFS). El análisis primario planificado a los 5 años de seguimiento no pudo confirmar la no inferioridad de la ME frente a la ME con LLND. Este estudio tuvo como objetivo comparar la ME como procedimiento único y la ME con LLND utilizando datos de seguimiento a largo plazo del ensayo JCOG0212. MÉTODOS: En este estudio se incluyeron pacientes con cáncer de recto en estadio clínico II/III por debajo de la reflexión peritoneal sin ganglios linfáticos aumentados de tamaño en la pared pélvica lateral. Después de que los cirujanos confirmaran la resección R0 mediante la ME, los pacientes fueron asignados al azar al brazo de ME sola o al brazo de ME con LLND. El criterio de valoración principal fue la supervivencia libre de recidiva (RFS). RESULTADOS: Un total de 701 pacientes de 33 instituciones fueron asignados al azar para ser tratados mediante una ME con LLND (n = 351) o EM sola (n = 350) entre junio de 2003 y agosto de 2010. Las tasas de RFS a 7 años fueron del 71,1% para ME con LLND y 70,7 % para ME sola (cociente de riesgos instantáneos, hazard ratio, HR: 1,09 (i.c. del 95% 0,84-1,42), no inferioridad P = 0,064)). El análisis de subgrupos mostró una mejor RFS entre los pacientes en estadio clínico III que se sometieron a ME con LLND en comparación con ME sola (HR: 1,49 (i.c. del 95%: 1,02-2,17)). CONCLUSIÓN: Los datos de seguimiento a largo plazo no justificaron la no inferioridad de la ME en comparación con la ME con LLND. Se recomienda la ME con LLND para pacientes en estadio clínico III, mientras que LLND podría omitirse para pacientes en estadio clínico II.


Subject(s)
Lymph Node Excision , Proctectomy/methods , Rectal Neoplasms/surgery , Disease-Free Survival , Equivalence Trials as Topic , Follow-Up Studies , Humans , Lymph Nodes/pathology , Middle Aged , Neoplasm Recurrence, Local , Neoplasm Staging , Rectal Neoplasms/pathology
3.
4.
Int J Oral Maxillofac Surg ; 45(12): 1520-1525, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27634690

ABSTRACT

The purpose of this study was to compare computed tomography (CT) Hounsfield unit values of bone fragment gaps after sagittal split ramus osteotomy (SSRO) in patients with and without asymmetry, and to evaluate differences between the deviated and non-deviated sides in asymmetric patients. Thirty-two patients who underwent a bilateral SSRO were included in this retrospective study. Patients were divided into symmetric and asymmetric groups by cephalometric analysis. CT values of the bone fragment gap were measured at 1 week and at 1 year after surgery. There were significant differences between CT values obtained at 1 week and at 1 year after surgery for all measurement points. However, there were no significant differences in CT values between symmetric and asymmetric patients at either 1 week or 1 year after surgery. Among asymmetric patients, there were no significant differences between the deviated and non-deviated sides at 1 week or 1 year after surgery. This study showed ossification of the bone fragments and adaptation to change the mandible form in patients with and without asymmetry following SSRO.


Subject(s)
Facial Asymmetry/diagnostic imaging , Osteotomy, Sagittal Split Ramus , Prognathism/diagnostic imaging , Adolescent , Adult , Cephalometry , Facial Asymmetry/surgery , Female , Humans , Male , Malocclusion, Angle Class III , Mandible/diagnostic imaging , Middle Aged , Prognathism/surgery , Retrospective Studies , Time Factors , Tomography, X-Ray Computed , Young Adult
5.
Br J Surg ; 102(5): 495-500, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25727933

ABSTRACT

BACKGROUND: The best suture method to prevent incisional surgical-site infection (SSI) after clean-contaminated surgery has not been clarified. METHODS: Patients undergoing elective colorectal cancer surgery at one of 16 centres were randomized to receive either subcuticular sutures or skin stapling for skin closure. The primary endpoint was the rate of incisional SSI. Secondary endpoints of interest included time required for wound closure, incidence of wound problems, postoperative length of stay, wound aesthetics and patient satisfaction. RESULTS: A total of 1264 patients were enrolled. The cumulative incidence of incisional SSI by day 30 after surgery was similar after subcuticular sutures and stapled closure (8·7 versus 9·8 per cent respectively; P = 0·576). Comparison of cumulative incidence curves revealed that SSI occurred later in the subcuticular suture group (P = 0·019) (hazard ratio 0·66, 95 per cent c.i. 0·45 to 0·97). Wound problems (P = 0·484), wound aesthetics (P = 0·182) and postoperative duration of hospital stay (P = 0·510) did not differ between the groups; subcuticular sutures took 5 min longer than staples (P < 0·001). Patients in the subcuticular suture group were significantly more satisfied with their wound (52·4 per cent versus 42·7 per cent in the staple group; P = 0·002). CONCLUSION: Compared with skin stapling, subcuticular sutures did not reduce the risk of incisional SSI after colorectal surgery. REGISTRATION NUMBER: UMIN000004001 (http://www.umin.ac.jp/ctr).


Subject(s)
Colorectal Neoplasms/surgery , Surgical Wound Infection/epidemiology , Suture Techniques , Adult , Aged , Aged, 80 and over , Elective Surgical Procedures/methods , Female , Humans , Length of Stay/statistics & numerical data , Male , Middle Aged , Perioperative Care , Surgical Stapling/methods , Surgical Wound Infection/etiology
7.
Endoscopy ; 44(12): 1139-48, 2012 Dec.
Article in English | MEDLINE | ID: mdl-22932809

ABSTRACT

BACKGROUND AND STUDY AIMS: A new overtube system has been developed for steady pressure automatically controlled endoscopy (SPACE) in the gastrointestinal tract. The objectives of this study were to validate the feasibility and safety of SPACE in the esophagus, and to evaluate its potential advantages over conventional (manually insufflating) endoscopy in endoscopic submucosal dissection (ESD). METHODS: This was a multicenter preclinical trial using acute porcine models (n = 20). In Experiment 1 (feasibility/safety study), SPACE was attempted in the esophagus with continuous monitoring of cardiopulmonary parameters and intraluminal pressures in the downstream bowel. Different insufflation pressures were tested to optimize the insufflation condition. Each session was video-recorded and scored by blinded reviewers. In Experiment 2 (randomized trial), esophageal ESD was attempted using either SPACE or conventional endoscopy, and results were compared. RESULTS: In Experiment 1, SPACE was performed safely without intraluminal pressure elevation in the downstream bowel. According to video review, SPACE provided more stable, reproducible, and rapid visualization than conventional endoscopy. The insufflation pressure was optimized at 14 mmHg for esophageal SPACE. In Experiment 2, ESD was completed in all animals. The ESD time was significantly shorter with SPACE compared with conventional endoscopy (1326 vs. 1616 seconds; P = 0.009). Responses to questionnaires showed that 94 % - 100 % of participants considered SPACE to provide improved exposure and more uniform tissue tension than conventional endoscopy. Other data were comparable. CONCLUSIONS: SPACE is feasible, safe, and potentially effective for complicated endoscopic procedures, such as ESD. SPACE improves and standardizes endoscopic exposure and tissue tension. A clinical study is required to further confirm its safety and clinical effectiveness.


Subject(s)
Dissection/methods , Esophagoscopy/methods , Esophagus/surgery , Insufflation/methods , Animals , Automation , Disease Models, Animal , Equipment Design , Equipment Safety , Esophagoscopes , Feasibility Studies , Japan , Minimally Invasive Surgical Procedures/methods , Mucous Membrane/surgery , Pressure , Random Allocation , Sensitivity and Specificity , Swine
8.
AJNR Am J Neuroradiol ; 31(4): 668-73, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20019106

ABSTRACT

BACKGROUND AND PURPOSE: Pedicle involvement on MR imaging has been considered specific for malignancy. However, we also noted the findings in many patients with osteoporosis and hypothesized that it is not specific for malignant lesions. The aim of this study was to evaluate the prevalence of pedicle involvement in painful osteoporotic compression fractures and to determine whether the sign is specific for malignancy. MATERIALS AND METHODS: We retrospectively reviewed MR images and CT scans of 152 patients who underwent PV for painful compression fractures. There were 140 patients (225 vertebrae) with osteoporotic fractures and 12 patients (19 vertebrae) with malignant fractures. Three radiologists evaluated the degree and extent of signal-intensity changes of the pedicle on MR imaging by consensus. The CT findings were also evaluated. The chi(2) test was used for statistical analyses. RESULTS: Of the 225 vertebrae of osteoporotic fractures and 19 vertebrae of malignant fractures, pedicle involvement on MR imaging was seen in 144 (64%) and 16 (84.2%) vertebrae, respectively, and there was no statistically significant difference (P = .065). Positive pedicle involvement in osteoporotic fractures was seen in 84 (77%) of 109 vertebrae with early-phase fractures (< or =3 months) and 60 (51.7%) of 116 vertebrae with chronic-phase fractures (>3 months), and this was statistically significant (P < .001). Among 144 osteoporotic vertebrae that showed positive pedicle involvement on MR imaging, 45 (31%) showed pedicle fractures and 55 (38.2%) showed sclerotic change on CT. CONCLUSIONS: Pedicle involvement was seen frequently in patients with osteoporotic compression fractures and was not specific for malignancy in our study group.


Subject(s)
Fractures, Compression/diagnosis , Fractures, Spontaneous/diagnosis , Image Processing, Computer-Assisted , Lumbar Vertebrae , Magnetic Resonance Imaging , Osteoporosis/diagnosis , Spinal Fractures/diagnosis , Spinal Neoplasms/secondary , Thoracic Vertebrae , Tomography, X-Ray Computed , Aged , Aged, 80 and over , Diagnosis, Differential , Female , Follow-Up Studies , Fractures, Compression/surgery , Fractures, Spontaneous/surgery , Humans , Lumbar Vertebrae/pathology , Lumbar Vertebrae/surgery , Male , Middle Aged , Osteoporosis/surgery , Retrospective Studies , Sensitivity and Specificity , Spinal Fractures/surgery , Spinal Neoplasms/diagnosis , Thoracic Vertebrae/pathology , Thoracic Vertebrae/surgery , Vertebroplasty
9.
J Vet Intern Med ; 23(4): 824-31, 2009.
Article in English | MEDLINE | ID: mdl-19496915

ABSTRACT

BACKGROUND: Mitral valve regurgitation (MR) causes increased left atrial pressure (LAP) and is associated with occurrence of clinical signs. It will be useful to understand diurnal variations of LAP for the management of MR. HYPOTHESIS: Circulatory parameters and diurnal rhythm are linked to clinical signs in cardiac diseases. LAP also exhibits a diurnal rhythm in dogs with MR. ANIMALS: Five healthy Beagle dogs weighing 9.8-12.8 kg (3 males and 2 females; aged 2 years) were used. METHODS: A radiotelemetry system for continuous measurement of LAP was used in this study. Rupture of the chordae tendineae was experimentally induced via left atriotomy, and a transmitter catheter was inserted into the left atrium. The body of the transmitter was implanted SC. After clinical condition was stabilized, the severity of MR was evaluated by echocardiography, and LAP was recorded for 72 consecutive hours for the analysis of diurnal variation. RESULTS: Abrupt increases in LAP, which averaged 16.7 mmHg, were observed at feeding periods. In contrast, strong diurnal LAP variations were found, with a significant but slight increase in daytime LAP compared with nighttime LAP. CONCLUSIONS AND CLINICAL IMPORTANCE: Diurnal LAP is characterized by a slight but significant nocturnal decrease and abrupt increases in response to excitation. The latter seemed to be more important considering the relationship with clinical manifestations. The clinical relevance of exercise restriction in the management of MR was acknowledged.


Subject(s)
Circadian Rhythm , Dog Diseases/pathology , Mitral Valve Insufficiency/veterinary , Ventricular Pressure/physiology , Animals , Dogs , Female , Heart Atria , Male , Mitral Valve Insufficiency/pathology
10.
Aust Vet J ; 87(3): 88-93, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19245618

ABSTRACT

OBJECTIVE: To assess the efficacy of an open patch-graft technique under cardiopulmonary bypass (CPB) in small dogs. DESIGN AND METHODS: A retrospective analysis of 10 dogs with pulmonic stenosis. Records between 1992 and 2002 were reviewed. The effect of surgical correction was evaluated and perioperative parameters were compared between survivors and non-survivors. RESULTS: The postoperative pulmonary pressure gradient was reduced in all seven surviving patients. Mean +/- SE was 21.5 +/- 7.4 mmHg (range 3.0-54.2 mmHg) and 6/7 dogs were < 40 mmHg at 3 months postoperatively. Comparing the data between those patients that survived and those that did not, the preoperative pressure gradient (P = 0.04) and volume of the Glucose-Insulin-Kalium solution used (P = 0.001) were significantly higher in those that did not survive. CONCLUSION: Open patch-grafting can be performed in small-breed dogs and decreased the pulmonary pressure gradient in survivors at 3 months postoperatively. However, this technique is more invasive than balloon valvuloplasty and should be used cautiously in severely stenosed patients.


Subject(s)
Cardiopulmonary Bypass/veterinary , Dog Diseases/surgery , Postoperative Complications/veterinary , Pulmonary Valve Stenosis/veterinary , Animals , Cardiopulmonary Bypass/methods , Dogs , Female , Glucose/therapeutic use , Insulin/therapeutic use , Male , Perioperative Care , Postoperative Complications/epidemiology , Postoperative Complications/mortality , Potassium/therapeutic use , Pulmonary Valve Stenosis/mortality , Pulmonary Valve Stenosis/surgery , Retrospective Studies , Survival Analysis , Treatment Outcome
11.
AJNR Am J Neuroradiol ; 28(3): 567-9, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17353338

ABSTRACT

BACKGROUND AND PURPOSE: The purpose of this study is to estimate the change in partial pressure of oxygen (Pao(2)) during percutaneous vertebroplasty and also to examine the factors related to the change in Pao(2). MATERIALS AND METHODS: We retrospectively reviewed preprocedural and postprocedural Pao(2) of 59 consecutive patients who underwent percutaneous vertebroplasty between November 2003 and April 2005 (11 men and 48 women; age range, 50-93; mean age, 75 years). Fifty-four patients were treated for osteoporosis-related fractures and 5 had malignant disease. Percutaneous vertebroplasty was performed in a conventional manner under local anesthetics and conscious sedation. Preprocedural and postprocedural blood drawing was performed 5 days to 30 minutes before percutaneous vertebroplasty and also at 30 minutes after the injection of bone cement. The difference between preprocedural and postprocedural data of Pao(2) was correlated with patients' age, number of treated vertebral bodies, presence of cement leakage, and presence of malignant neoplasm for each patient. RESULTS: Mean pre-Pao(2) and post-Pao(2) were 80.9 +/- 1.4 and 70.6 +/- 1.3 mm Hg (mean +/- SE) respectively (P = .0001). Using analysis of variance, there was a significant difference according to the number of vertebral bodies. There was a positive trend of decrease in Pao(2) according to the number of vertebral bodies during percutaneous vertebroplasty. Using multiple linear regression and after adjusting by preprocedural Pao(2) and other variables, the number of vertebral bodies was still highly significant. CONCLUSION: Pao(2) decreases during percutaneous vertebroplasty, and there is a correlation between the number of treated vertebral bodies and decrease in Pao(2).


Subject(s)
Orthopedic Procedures , Oxygen/blood , Spinal Fractures/blood , Spinal Fractures/therapy , Aged , Aged, 80 and over , Anesthesia, Local , Bone Cements/therapeutic use , Conscious Sedation , Female , Humans , Linear Models , Male , Middle Aged , Osteoporosis/complications , Partial Pressure , Polymethyl Methacrylate/therapeutic use , Retrospective Studies , Severity of Illness Index , Spinal Fractures/etiology , Time Factors
12.
Acta Gastroenterol Belg ; 70(4): 323-30, 2007.
Article in English | MEDLINE | ID: mdl-18330087

ABSTRACT

BACKGROUND AND STUDY AIMS: Endoscopic submucosal dissection (ESD) has recently gained popularity for use against intramucosal gastric neoplasms in Japan, but few studies have examined whether ESD is feasible for elderly patients. This study aims are to evaluate the efficacy and safety of ESD according to age in consecutive elderly patients treated with ESD. PATIENTS AND METHODS: Subjects comprised 116 patients (90 men, 26 women) with 125 lesions treated using ESD from November 2002 to March 2006 at Nagoya City University Hospital and Iwata Municipal Hospital, Japan. Patients were categorized into: Group A, <65-years-old (n=34); Group B, > or =65-years-old but <75-years-old (n=41); and Group C, > or = 75-years-old (n=41). En bloc resection rate and treatment time were examined according to age, tumour size and location, and frequency of complications was examined according to age. RESULTS: Rate of concomitant disease was significantly higher in Group C than in the other groups. En bloc resection rates and median treatment times were 91.4% and 80 min in Group A, 91.1% and 97 min in Group B and 86.7% and 110 min in Group C, respectively. No significant differences were noted between groups, or for en bloc resection rate and treatment time according to tumour size and location, or between groups for frequency of complications. CONCLUSIONS: ESD for gastric neoplasms is effective and safe in elderly patients, and may be positively recommended to elderly patients with intramucosal gastric neoplasms.


Subject(s)
Dissection/methods , Gastric Mucosa/surgery , Gastroscopy/methods , Stomach Neoplasms/surgery , Adenocarcinoma/pathology , Adenocarcinoma/surgery , Adenoma/pathology , Adenoma/surgery , Adult , Age Factors , Aged , Aged, 80 and over , Biopsy , Blood Loss, Surgical , Endosonography , Feasibility Studies , Female , Gastrectomy/methods , Humans , Male , Middle Aged , Postoperative Complications , Postoperative Hemorrhage/etiology , Stomach/injuries , Stomach Neoplasms/pathology , Time Factors , Treatment Outcome
13.
Acta Radiol ; 45(6): 608-15, 2004 Oct.
Article in English | MEDLINE | ID: mdl-15587416

ABSTRACT

PURPOSE: To evaluate image subtraction in a three-dimensional contrast-enhanced magnetic resonance angiography (3D CE-MRA) using fat suppression for the hemodialysis fistula. MATERIAL AND METHODS: Fifteen patients suffering from hemodialysis fistula dysfunction were imaged with 3D CE-MRA using fat suppression and digital subtraction angiography (DSA). Non-subtracted and subtracted MRA images using maximum intensity projection (MIP) were constructed and the validity of the MRA interpretations of the degree of vascular stenoses was evaluated using DSA as the standard of reference. Image quality was assessed using qualitative analysis (vessel contrast) and quantitative analysis (contrast-to-noise ratio (CNR) of the vessel versus the background). RESULTS: In the vessels with stenosis of 50% or greater, the sensitivity and specificity of the non-subtracted MRA were 89.5% and 81.8%, respectively, and of the subtracted MRA 89.5% and 86.4%, respectively. There was no significant difference in the detectability of stenoses between either MRA. The vessel contrast of the anterior interosseous artery and the CNR of the anterior interosseous artery versus the background on the subtracted MRA were significantly superior to those on the non-subtracted MRA. With regard to the radial artery and cephalic vein, there was no significant difference in the vessel contrast and CNR between either MRA. CONCLUSION: Both subtracted and non-subtracted MRA techniques are useful in detecting hemodialysis fistula dysfunction.


Subject(s)
Magnetic Resonance Angiography/methods , Renal Dialysis , Subtraction Technique , Angiography, Digital Subtraction , Arteriovenous Shunt, Surgical , Contrast Media , Female , Gadolinium DTPA , Humans , Imaging, Three-Dimensional , Injections, Intravenous , Male , Middle Aged , Sensitivity and Specificity
14.
Surg Endosc ; 16(5): 855-8, 2002 May.
Article in English | MEDLINE | ID: mdl-11997837

ABSTRACT

BACKGROUND: The aim of this study was to assess the outcome of laparoscopic colorectal surgery in obese patients and compare it to that of a nonobese group of patients who underwent similar procedures. METHODS: All 162 consecutive patients who underwent an elective laparoscopic or laparoscopic-assisted segmental colorectal resection between August 1991 and December 1997 were evaluated. Body mass index (BMI; kg/m2) was used as an objective index to indicate massive obesity. The parameters analyzed included BMI, age, gender, comorbid conditions, diagnosis, procedure, American Society of Anesthesiologists classification score, operative time, estimated blood loss, transfusion requirements, intraoperative complications, conversion to laparotomy, postoperative complications, length of hospitalization, and mortality. RESULTS: Thirty-one patients (19.1%) were obese (23 males and 8 females). Conversion rates were significantly increased in the obese group (39 vs 13.5%, p = 0.01), with an overall conversion rate of 18%. The postoperative complication rate in the obese group was 78% versus 24% in the nonobese group (p <0.01). Specifically, rates of ileus and wound infections were significantly higher in the obese group [32.3 vs. 7.6% (p <0.01) and 12.9 vs 3.1%. (p = 0.03), respectively]. Furthermore, hospital stay in the obese group was longer (9.5 days) than in the nonobese group (6.9 days, p = 0.02). CONCLUSION: Laparoscopic colorectal segmental resections are feasible in obese patients. However, increased rates of conversion to laparotomy should be anticipated and the risk of postoperative complications is significantly increased, prolonging the length of hospitalization when compared to that of nonobese patients.


Subject(s)
Colorectal Surgery/methods , Laparoscopy/methods , Obesity/complications , Adolescent , Adult , Aged , Aged, 80 and over , Body Mass Index , Contraindications , Elective Surgical Procedures/methods , Female , Humans , Intraoperative Complications/etiology , Male , Middle Aged , Risk Factors
15.
Abdom Imaging ; 27(1): 9-14, 2002.
Article in English | MEDLINE | ID: mdl-11740599

ABSTRACT

BACKGROUND: To define radiographically simple prolapse or intussusception in cases of distal migration of duodenal tumors. METHODS: In one pyloric and four duodenal tumors showing distal migration, the findings of gastrointestinal contrast examinations were retrospectively evaluated in relation to CT and operative findings. RESULTS: All lesions were intraluminal growing and well demarcated, and they included two carcinoids, a papillary adenoma, a Brunner's gland adenoma, and a hyperplastic polyp. All lesions were accompanied by long mucosal stalks, and, in three, folding deformity of the proximal jejunum was observed. CT showed no target signs except for one with gastroduodenal intussusception. Intussusception was not verified surgically in any cases. CONCLUSION: Distal migration of duodenal tumors can occur as the result of mucosal elongation and slipping. Duodenojejunal intussusception is not necessarily associated with that phenomenon.


Subject(s)
Adenoma/diagnostic imaging , Carcinoid Tumor/diagnostic imaging , Duodenal Neoplasms/diagnostic imaging , Intussusception/diagnostic imaging , Polyps/diagnostic imaging , Adenoma/complications , Adult , Brunner Glands/pathology , Carcinoid Tumor/complications , Duodenal Neoplasms/complications , Female , Humans , Hyperplasia , Intussusception/etiology , Male , Middle Aged , Polyps/pathology , Retrospective Studies , Tomography, X-Ray Computed
16.
Abdom Imaging ; 26(4): 423-4, 2001.
Article in English | MEDLINE | ID: mdl-11441558

ABSTRACT

We report a rare case of prostatic abscess with Crohn's disease in a 21-year-old male. Computed tomography showed a typical prostatic abscess. Moreover, filling of the abscess cavities with contrast medium was demonstrated after micturition, which represented the rupturing of the abscess into the urethra. Crohn's disease should be included in the differential diagnosis of prostatic abscesses even in young males.


Subject(s)
Abdominal Abscess/etiology , Candidiasis/etiology , Crohn Disease/complications , Enterococcus , Gram-Positive Bacterial Infections/etiology , Prostatic Diseases/etiology , Adult , Age Factors , Humans , Male
18.
Hepatogastroenterology ; 48(39): 859-63, 2001.
Article in English | MEDLINE | ID: mdl-11462942

ABSTRACT

BACKGROUND/AIMS: Pancreatic cancer is extremely refractory even to aggressive treatments including surgery, resulting in early metastasis and/or local recurrence. We investigated changes in serum tumor marker CA 19-9 levels during preoperative radiotherapy in conjunction with initial treatment failure. METHODOLOGY: Twenty-three patients presenting with localized disease and an increased serum CA 19-9 level, who were slated to undergo pancreatectomy and/or intraoperative radiotherapy following preoperative radiotherapy were reviewed. CA 19-9 response, the ratio of post-radiotherapy level before laparotomy to pre-radiotherapy level, was analyzed in relation to disease-control time and survival. RESULTS: Eleven patients revealed metastasis at restaging or laparotomy; 12 patients (52%) completed aggressive treatments. Initial failure was identified at the liver (52%), peritoneum (52%), or local site (26%) with a median disease-control time of 91 days; 7 patients showed combined failure. All but 1 patient died of cancer with a median survival time of 264 days. CA 19-9 response (range: 0-1185%) did not correlate with disease-control time or survival; 8 progressive-disease patients (> 140% response), however, showed significantly shorter disease-control time than 15 nonprogressive-disease patients (< or = 140% response). CONCLUSIONS: CA 19-9 monitoring is useful in preoperative radiotherapy for identifying patients who will not benefit by succeeding aggressive treatments by predicting early metastasis.


Subject(s)
Biomarkers, Tumor/blood , CA-19-9 Antigen/blood , Neoadjuvant Therapy , Pancreatectomy , Pancreatic Neoplasms/radiotherapy , Adult , Aged , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Pancreatic Neoplasms/blood , Pancreatic Neoplasms/mortality , Pancreatic Neoplasms/surgery , Radiotherapy Dosage , Retrospective Studies , Survival Rate , Treatment Failure
19.
J Comput Assist Tomogr ; 25(3): 348-54, 2001.
Article in English | MEDLINE | ID: mdl-11351182

ABSTRACT

PURPOSE: The purpose of this work was to survey the spectrum of CT findings in intrahepatic portosystemic venous shunts (IPSVSs). METHOD: One thousand consecutive liver CT scans examined with an enhanced helical technique were retrospectively reviewed on workstation to find IPSVSs. RESULTS: IPSVSs were noted in 37 patients and divided into two subtypes according to the location of the communicating systemic vein, either outside (external type, n = 34) or within (n = 4) the liver (one patient had both internal and external types). All the external-type shunts were noted in cases with portal hypertension (n = 34). Most shunts (n = 30) ran through segment 4 and/or 3 and came out near the falciform ligament, but five shunts were noted in segment 2 communicating either with the systemic vein (n = 3) or probably with an enlarged left gastric vein (n = 2). Solitary portohepatic venous shunts (internal type) were noted in three cases with (n = 2) or without (n = 1) aneurysmal dilatation and many portohepatic venous shunts in another patient. CONCLUSION: IPSVSs of the external type were far common than those of the internal type, always associated with increased pressure of the portal system and in specific sites probably lacking the hepatic capsule.


Subject(s)
Fistula/diagnostic imaging , Hepatic Veins/diagnostic imaging , Liver/blood supply , Portal Vein/diagnostic imaging , Tomography, X-Ray Computed , Adult , Aged , Aged, 80 and over , Collateral Circulation , Female , Humans , Liver/diagnostic imaging , Male , Middle Aged , Retrospective Studies
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