ABSTRACT
Three groups of the parameters of the therapeutic effects of 3 and 4 antituberculous drugs on renal tuberculous inflammation were identified. The primary effect of 4 drugs was much frequently manifested itself by the normalization of urinalysis and the transfer of cultured to uncultured Mycobacterium tuberculosis (MBT). The equivalent effect of 3 and 4 drugs was characterized by the similar rate of continuation of specific mycobacteriuria, by the detection of MBT in the cavernous contents from the removed tuberculosis-afflicted kidney and by the equivalent morphological characteristics of tuberculous inflammation involution. The negative impact of the therapeutic action of 4-component chemotherapy appeared as a much larger number of cases of intolerance of antituberculous drugs, hepatic and renal failures, and toxic-and-allergic reactions.
Subject(s)
Antitubercular Agents/classification , Antitubercular Agents/therapeutic use , Tuberculosis, Renal/drug therapy , HumansABSTRACT
The prevalence and incidence rates of urogenital tuberculosis in the Ukraine in the past 10 years were studied. They tended to decrease in the first period (1988-1992) and to become stable in the second period (1993-1997), being equal to 10.71 and 1.0 per 100,000. In the past 5 years, the incidence of urogenital tuberculosis tended to increase among urban residents as compared to rural ones. These changes show a total trend in the population living in the radioactively polluted area.
Subject(s)
Tuberculosis, Urogenital/epidemiology , Air Pollution, Radioactive , Cohort Studies , Cross-Sectional Studies , Humans , Power Plants , Radioactive Hazard Release , Rural Population , Ukraine/epidemiology , Urban PopulationABSTRACT
On the basis of mathematical-statistical analysis of clinical data, 5 risk degrees permitting to predict the course of the disease were distinguished. An algorithm for management of the urologic patients is suggested.
