ABSTRACT
Herein, we introduce new ratiometric 2,4,6-triamino-1,3,5-triazine-based probes (R1 and R2) having three different binding sites for three metal ion binders, which can selectively detect Zn2+ ions and, particularly, the probe R1 strongly interacts with the human lung cancer cell line (A549). Both the probes R1 and R2 are competently selective towards the Zn2+ ions with the detection limits of 1.22 × 10-7 M and 1.13 × 10-7 M, respectively. The changes in the structure and absorption properties of the probes are explained by density functional theory (DFT) and time dependent density functional theory (TDDFT) calculations. The absorption and fluorescence color change in the solid TLC plate makes it a brilliant Zn2+ sensor in a portable form.
Subject(s)
Colorimetry , Lung Neoplasms , Humans , Ions , Spectrometry, Fluorescence , Triazines , ZincABSTRACT
A new coumarin based turn on fluorescent sensor (R1) was reported for the detection of highly hazardous Cd2+ with excellent selectivity and sensitivity without any interference of other metal ions. The single crystal X-ray structure analysis of the sensor showed the actual geometry of the molecule. For the first time, a Cd2+ induced FRET mechanism was observed and explained accordingly. Instant naked eye detection of Cd2+ through a sharp colour change signified the practical applicability of R1. The sensor of high quantum yield was applied in the intracellular detection of poisonous Cd2+ in living HeLa S3 cells.
ABSTRACT
Lead ion induced P-O bond breaking with instant colour change was observed in a tripodal hydroxyl-quinoline based phosphor-ester (). A new penta-coordinated lead chelate complex [Pb4HQ6(ClO4)2] was found. The hydrolysis reaction followed by P-O bond cleavage with 'Pb-O' and 'Pb-N' bond formation proved the chemodosimeter approach.
