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J Fr Ophtalmol ; 23(3): 217-20, 2000 Mar.
Article in French | MEDLINE | ID: mdl-10740045

ABSTRACT

PURPOSE: We report 3 cases of familial amyloid polyneuropathy type I (FAP) with amyloid infiltration of the vitreum and glaucoma. PATIENTS AND METHODS: We reviewed the records of three patients, 2 females and one male, aged 41, 47 and 83 years respectively. The 3 patients had familial amyloid polyneuropathy type I with vitreous infiltration and open angle glaucoma. The two women underwent a liver graft four years earlier. Vitrectomy allowed confirmation of the diagnosis in the 83-year-old patient. Two patients underwent trabeculectomy, histological analysis of the iris and the trabeculum was obtained for one patient. RESULTS: The tree patients presented a polyneuropathy, vitreous infiltration and open angle glaucoma. Results of light microscopy of the iris and the trabeculum showed amyloid deposits in the iris and the trabecular meshworks. CONCLUSION: Familial amyloid polyneuropathy is a hereditary disease which may have a wide range of ocular manifestations. Glaucoma is among the most serious complications of familial amyloid polyneuropathy.


Subject(s)
Amyloid Neuropathies/complications , Glaucoma/complications , Adult , Aged , Aged, 80 and over , Amyloid Neuropathies/diagnosis , Chronic Disease , Congo Red , Female , Glaucoma/diagnosis , Glaucoma/surgery , Humans , Male , Middle Aged , Trabeculectomy , Visual Acuity
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