ABSTRACT
OBJECTIVES: The aim of this study is to evaluate the screening for trisomy 21 (T21) between 2011 and 2013 on Martinique French West Indies after the decree of 23 June 2009. MATERIALS AND METHODS: Were used the prenatal data provided by accredited laboratories and the data from the Registry of Congenital French West Indies (REMALAN). RESULTS: A total of 85.9 % of patients underwent screening: 60.5 % on a combined calculation of risk (CRC), 14.6 % on a sequential calculation of risk (CRS) and 10.8 % on serum markers 2nd trimester (MST2). Overall 5.4 % of the patients were placed in a risk group. During this period, 47 trisomy 21 were identified by the REMALAN which 38 (80.1 %) were detected prenatally: 24 of CRC, 3 on MST2 and 11 on signs of ultrasound at the 1st and 2nd trimester. The sensitivity of the CRC was 88 % for a false positive rate of 3.87 %. The overall sensitivity of screening (CRC, CRS and MST2) was 87 % for a false positive rate of 5.21 %. CONCLUSION: These data show that the coverage rate in Martinique is satisfactory and the screening fir Down syndrome meet expectations.
Subject(s)
Delivery of Health Care/standards , Down Syndrome/diagnosis , Prenatal Diagnosis/standards , Registries , Adult , Delivery of Health Care/statistics & numerical data , Female , Humans , Martinique , Pregnancy , Prenatal Diagnosis/statistics & numerical dataABSTRACT
The functional anatomy of the spinal column has mainly been studied in the cadaver. The aim of our study was to determine in vivo the normal axial rotation of the cervical column using computed tomography (CT). Sixty subjects, divided into decades from 20 to 80 years of age were studied. The CT protocol comprised an axial cut at the level of the skull base (C0) and at each vertebral level in the neck, in the neutral position (with the nasal septum vertical) and during rotation of the head. To reduce the exposure to irradiation the subjects were divided into two groups: 40 were studied from C0 to the fifth cervical vertebra (C5) with unilateral rotation at C0 of 10 degrees, 20 degrees and 40 degrees (20 rotations to the left and 20 to the right), and 20 subjects were studied from C0 to the first thoracic vertebra (T1) with a maximum rotation at C0 to left and right. The angular position of a vertebra was defined as the anteroposterior axis with reference in the neutral position to the axis of C0, and in rotation was related to its original axis. At each vertebral level the mean angle of rotation and its standard deviation were calculated (n = 30) for the successive intermediate and maximum rotations at C0 level. The rotation of the cervical spine took place mainly at two levels: 58% between C1 and C2 and 24% between C3 and C6. The pairs of vertebrae C0/C1 and C2/C3 provided functional couples where the rotation was minimal.(ABSTRACT TRUNCATED AT 250 WORDS)
